A comparative analysis of cytokine production and tolerance induction by bacterial lipopeptides, lipopolysaccharides and Staphyloccocus aureus in human monocytes

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Genomic sequencing.

1984 • 8,343 citations

CD14, a Receptor for Complexes of Lipopolysaccharide (LPS) and LPS Binding Protein

1990 • 4,041 citations

Secretory products of macrophages.

1987 • 2,670 citations

Structure and Function of Lipopolysaccharide Binding Protein

1990 • 1,689 citations

Gram-positive cell walls stimulate synthesis of tumor necrosis factor alpha and interleukin-6 by human monocytes

1994 • 347 citations

Requirement for lipopolysaccharide-responsive macrophages in galactosamine-induced sensitization to endotoxin

1986 • 340 citations

The role of cachectin/TNF in endotoxic shock and cachexia

1988 • 335 citations

Involvement of CD14 in lipopolysaccharide-induced tumor necrosis factor-alpha, IL-6 and IL-8 release by human monocytes and alveolar macrophages.

1993 • 328 citations

Tolerance to lipopolysaccharide involves mobilization of nuclear factor kappa B with predominance of p50 homodimers.

1994 • 315 citations

Induction of tolerance to lipopolysaccharide (LPS)-D-galactosamine lethality by pretreatment with LPS is mediated by macrophages

1988 • 233 citations

Tumor necrosis factor alpha mediates lethal activity of killed gram-negative and gram-positive bacteria in D-galactosamine-treated mice

1991 • 231 citations

Plasma lipopolysaccharide (LPS)-binding protein. A key component in macrophage recognition of gram-negative LPS.

1992 • 224 citations

Adaptation to bacterial lipopolysaccharide controls lipopolysaccharide-induced tumor necrosis factor production in rabbit macrophages.

1990 • 214 citations

Control of lipopolysaccharide (LPS) binding and LPS-induced tumor necrosis factor secretion in human peripheral blood monocytes.

1992 • 213 citations

Surface Phenotype Analysis of Human Monocyte to Macrophage Maturation

1990 • 213 citations

Intravenous endotoxin suppresses the cytokine response of peripheral blood mononuclear cells of healthy humans.

1993 • 195 citations

Induction of release of tumor necrosis factor from human monocytes by staphylococci and staphylococcal peptidoglycans

1993 • 194 citations

Tolerance to endotoxin-induced expression of the interleukin-1 beta gene in blood neutrophils of humans with the sepsis syndrome.

1993 • 192 citations

Molecules from Staphylococcus aureus that bind CD14 and stimulate innate immune responses.

1995 • 177 citations

Soluble peptidoglycan-induced monokine production can be blocked by anti-CD14 monoclonal antibodies and by lipid A partial structures

1994 • 175 citations

Activation of human monocytic cells by Treponema pallidum and Borrelia burgdorferi lipoproteins and synthetic lipopeptides proceeds via a pathway distinct from that of lipopolysaccharide but involves the transcriptional activator NF-kappa B

1996 • 149 citations

The nonspecific nature of endotoxin tolerance

1995 • 126 citations

Stimulation of Human and Murine Adherent Cells by Bacterial Lipoprotein and Synthetic Lipopeptide Analogues

1988 • 116 citations

Endotoxin-macrophage interaction: post-translational regulation of tumor necrosis factor expression.

1989 • 116 citations

A labile transcriptional repressor modulates endotoxin tolerance.

1994 • 115 citations

In vitro desensitization to lipopolysaccharide suppresses tumour necrosis factor, interleukin-1 and interleukin-6 gene expression in a similar fashion.

1992 • 92 citations

Lipopolysaccharide (LPS) recognition in macrophages. Participation of LPS-binding protein and CD14 in LPS-induced adaptation in rabbit peritoneal exudate macrophages.

1993 • 87 citations

Activation of bone marrow‐derived mouse macrophages by bacterial lipopeptide: cytokine production, phagocytosis and Ia expression

1990 • 86 citations

Lipopeptide Derivatives of Bacterial Lipoprotein Constitute Potent Immune Adjuvants Combined with or Covalently Coupled to Antigen or Hapten

1989 • 82 citations

Induction of Tumor Cytotoxicity in Murine Bone Marrow-Derived Macrophages by Two Synthetic Lipopeptide Analogues

1989 • 58 citations

Modulation of endotoxin-induced monokine release in human monocytes by lipid A partial structures that inhibit binding of 125I-lipopolysaccharide

1992 • 53 citations

Chemical characteristics of Staphylococcus aureus molecules that have CD14-dependent cell-stimulating activity.

1996 • 47 citations

L-arginine-dependent nitric oxide formation and nitrite release in bone marrow-derived macrophages stimulated with bacterial lipopeptide and lipopolysaccharide.

1990 • 33 citations

Staphylococcus aureus and derived exotoxins induce nuclear factor kappa B-like activity in murine bone marrow macrophages

1992 • 31 citations

Differential release of TNF-alpha, IL 1, and PGE2 by human blood monocytes subsequent to interaction with different bacterial derived agents.

1990 • 30 citations

Modulation of interferon-γ-induced major histocompatibility (MHC) and CD14 antigen changes by lipophilic muramyltripeptide MTP-PE in human monocytes

1988 • 24 citations