N-Substituted Adenosines as Novel Neuroprotective A1 Agonists with Diminished Hypotensive Effects

Elevation of the Extracellular Concentrations of Glutamate and Aspartate in Rat Hippocampus During Transient Cerebral Ischemia Monitored by Intracerebral Microdialysis

1984 • 2,884 citations

Adenosine, an endogenous anti-inflammatory agent

1994 • 635 citations

Adenosine: A potential mediator of seizure arrest and postictal refractoriness

1992 • 462 citations

Pertussis toxin reverses adenosine inhibition of neuronal glutamate release

1985 • 247 citations

Purinergic approaches in experimental therapeutics

1997 • 238 citations

Activated human eosinophils generate SRS-A leukotrienes following IgG-dependent stimulation

1985 • 214 citations

Inflammatory Gene Expression in Cerebral Ischemia and Trauma

1997 • 207 citations

An adenosine analogue, 2-chloroadenosine, protects against long term development of ischaemic cell loss in the rat hippocampus

1987 • 195 citations

AMPA, but not NMDA, receptor antagonism is neuroprotective in gerbil global ischaemia, even when delayed 24 h

1993 • 192 citations

Excitatory Transmitter Amino Acid Release from the Ischemic Rat Cerebral Cortex: Effects of Adenosine Receptor Agonists and Antagonists

1992 • 173 citations

Status epilepticus may be caused by loss of adenosine anticonvulsant mechanisms

1994 • 154 citations

Novel functional M1 selective muscarinic agonists. Synthesis and structure-activity relationships of 3-(1,2,5-thiadiazolyl)-1,2,5,6-tetrahydro-1-methylpyridines

1992 • 151 citations

Massive Persistent Release of Excitatory Amino Acids Following Human Occlusive Stroke

1995 • 151 citations

Physiological and pharmacological properties of adenosine: Therapeutic implications

1991 • 145 citations

Adenosine and Adenosine Receptors

1990 • 142 citations

Functional characterization of three adenosine receptor types

1993 • 139 citations

Adenosine and Adenine Nucleotides: From Molecular Biology to Integrative Physiology

1995 • 129 citations

A3-adenosine receptors: Design of selective ligands and therapeutic prospects

1995 • 125 citations

Modulation of nerve and glial function by adenosine—role in the development of ischemic damage

1994 • 93 citations

Subtypes of adenosine receptors in the brainstem mediate opposite blood pressure responses

1991 • 73 citations

Effects of an A1 adenosine receptor agonist on the neurochemical, behavioral and histological consequences of ischemia

1994 • 63 citations

Convenient preparation of S-adenosylhomocysteine and related compounds

1976 • 60 citations

Dissociation of the locomotor and hypotensive effects of adenosine analogues in the rat

1984 • 51 citations

Unexpected neuroprotection observed with the adenosine A2A receptor agonist CGS 21680

1996 • 49 citations

Nucleic acid related compounds. 74. Synthesis and biological activity of 2'(and 3')-deoxy-2'(and 3')-methylenenucleoside analogs that function as mechanism-based inhibitors of S-adenosyl-L-homocysteine hydrolase and/or ribonucleotide reductase

1992 • 45 citations

Effect of Adenosine on Cerebral Blood Flow as Evaluated by Single-Photon Emission Computed Tomography in Normal Subjects and in Patients With Occlusive Carotid Disease

1995 • 38 citations

Cardiovascular actions of adenosines, but not adenosine receptors, differ in rat and guinea pig

1991 • 25 citations

Synthesis and characterization of 5-hydroperoxymethyluracil (Thy.alpha.OOH)

1976 • 25 citations

Functional characterization of adenosine receptors in the nucleus tractus solitarius mediating hypotensive responses in the rat

1996 • 25 citations

Selective protection by adenosine receptor agonists against DMCM-induced seizures

1991 • 23 citations

Focal cerebral ischemia in chronic hypertension: no protection by(R)-phenylisopropyladenosine

1991 • 21 citations

Evidence that adenosine receptors in the dog left atrium are not of the typical A1 or A2 adenosine receptor subtypes

1992 • 19 citations

Metabolic Effects of R-Phenylisopropyladenosine during Reversible Forebrain Ischemia Studied by in vivo ³¹P Nuclear Magnetic Resonance Spectroscopy

1991 • 16 citations

Adenosinergic modulation of the EEG and locomotor effects of the A2 agonist, CGS 21680

1993 • 15 citations

The therapeutic potential of agents acting via purine receptors

1998 • 12 citations

Effects of A ₁ Adenosine Receptor Agonism Using N ⁶ -Cyclohexyl-2′- O -Methyladenosine in Patients With Left Ventricular Dysfunction

1996 • 12 citations

Trials with an adenosine analogue as antianginal medication

1977 • 6 citations

Adenosine A₁ receptors in rat brain synaptosomes: Transductional mechanisms, effects on glutamate release, and preservation after metabolic inhibition

1995 • 5 citations

Characterization of [3H]-N-[R-(2- Benzothiazolyl)thio-2-propyl]-2-chloroadenosine ([3H]-NNC 21-0136) binding to rat brain: Profile of a novel selective agonist for adenosine A1 receptors

1997 • 4 citations

A Model Predicting Characteristics of Genetic Maps in Neurospora crassa

1965 • 3 citations

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