Differential effects of P₂‐purinoceptor antagonists on phospholipase C‐ and adenylyl cyclase‐coupled P_2Y‐purinoceptors

SOME QUANTITATIVE USES OF DRUG ANTAGONISTS

1959 • 3,948 citations

Extracellular ATP: effects, sources and fate

1986 • 1,666 citations

ADENOSINE REGULATES VIA TWO DIFFERENT TYPES OF RECEPTORS, THE ACCUMULATION OF CYCLIC AMP IN CULTURED BRAIN CELLS

1979 • 1,370 citations

Is there a basis for distinguishing two types of P2-purinoceptor?

1985 • 1,353 citations

Signal transduction via P2-purinergic receptors for extracellular ATP and other nucleotides

1993 • 1,259 citations

Subclasses of external adenosine receptors.

1980 • 1,087 citations

Cell membrane receptors for drugs and hormones: A multidisciplinary approach

1979 • 850 citations

A basis for distinguishing two types of purinergic receptor

1978 • 725 citations

Molecular cloning and characterization of an adenosine receptor: the A3 adenosine receptor.

1992 • 649 citations

Cloning and functional expression of a brain G‐protein‐coupled ATP receptor

1993 • 545 citations

Suramin: a reversible P₂‐purinoceptor antagonist in the mouse vas deferens

1988 • 426 citations

Further subclassification of ATP receptors based on agonist studies

1991 • 374 citations

Suramin antagonizes responses to P₂‐purinoceptor agonists and purinergic nerve stimulation in the guinea‐pig urinary bladder and taenia coli

1990 • 317 citations

PPADS, a novel functionally selective antagonist of P2 purinoceptor-mediated responses

1992 • 299 citations

Recent research on the biological activity of suramin.

1993 • 281 citations

Characterization of responses of isolated rat hepatocytes to ATP and ADP.

1985 • 269 citations

P2-purinergic receptors are coupled to two signal transduction systems leading to inhibition of cAMP generation and to production of inositol trisphosphate in rat hepatocytes.

1987 • 213 citations

Kinetics of Activation of Phospholipase C by P2Y Purinergic Receptor Agonists and Guanine Nucleotides

1989 • 206 citations

Involvement of inositol 1,4,5-trisphosphate and calcium in the action of adenine nucleotides on aortic endothelial cells.

1987 • 202 citations

Molecular cloning of a novel putative G‐protein coupled receptor expressed during rat spermiogenesis

1991 • 186 citations

Expression of a cloned P2Y purinergic receptor that couples to phospholipase C.

1994 • 177 citations

Activation of inositol phospholipid breakdown in HL60 cells by P2-purinergic receptors for extracellular ATP. Evidence for mediation by both pertussis toxin-sensitive and pertussis toxin-insensitive mechanisms.

1988 • 166 citations

Evidence that UTP and ATP regulate phospholipase C through a common extracellular 5'-nucleotide receptor in human airway epithelial cells.

1991 • 158 citations

Adenosine triphosphate stimulates inositol phospholipid metabolism and prostacyclin formation in adrenal medullary endothelial cells by means of P2-purinergic receptors.

1987 • 141 citations

Suramin is a slowly‐equilibrating but competitive antagonist at P_2x‐receptors in the rabbit isolated ear artery

1990 • 139 citations

Differential modification of the interaction of cardiac muscarinic cholinergic and beta-adrenergic receptors with a guanine nucleotide binding component(s).

1982 • 137 citations

PPADS selectively antagonizes P_2X‐purinoceptor‐mediated responses in the rabbit urinary bladder

1993 • 137 citations

Muscarinic cholinergic receptor-mediated activation of phosphodiesterase.

1982 • 133 citations

Identification of a P2Y-purinergic receptor that inhibits adenylyl cyclase.

1993 • 116 citations

Identification of potent, selective P2Y-purinoceptor agonists: structure-activity relationships for 2-thioether derivatives of adenosine 5'-triphosphate

1993 • 113 citations

Phosphoinositide hydrolysis by guanosine 5′-[γ-thio]triphosphate-activated phospholipase C of turkey erythrocyte membranes

1988 • 106 citations

A Permissive Role of Pertussis Toxin Substrate G-protein in P2-purinergic Stimulation of Phosphoinositide Turnover and Arachidonate Release in FRTL-5 Thyroid Cells

1989 • 99 citations

Structure activity relationships for derivatives of adenosine‐5′‐triphosphate as agonists at P₂ purinoceptors: Heterogeneity within P_2x and P_2y subtypes

1994 • 98 citations

Extracellular nucleotides stimulate receptor-mediated calcium mobilization and inositol phosphate production in human fibroblasts

1989 • 95 citations

The regulation of aortic endothelial cells by purines and pyrimidines involves co‐existing P_2y‐purinoceptors and nucleotide receptors linked to phospholipase C

1993 • 87 citations

Extracellular ATP stimulates three different receptor-signal transduction systems in FRTL-5 thyroid cells. Activation of phospholipase C, and inhibition and activation of adenylate cyclase

1992 • 60 citations

An electrophysiological analysis of the effect of reactive blue 2, a putative P2-purinoceptor antagonist, on inhibitory junction potential of rat caecum

1986 • 60 citations

Coomassie Brilliant Blue G is a more potent antagonist of P2 purinergic responses than Reactive Blue 2 (Cibacron Blue 3GA) in rat parotid acinar cells

1989 • 54 citations

The effect of reactive blue, an antagonist of ATP, on the isolated urinary bladders of guinea-pig and rat

1981 • 54 citations

Phosphatidylinositol 4,5-bisphosphate hydrolysis in turkey erythrocytes is regulated by P2y purinoceptors.

1989 • 52 citations

An assessment of the antagonistic activity of reactive blue 2 at P1- and P2-purinoceptors: supporting evidence fro purinergic innervation of the rabbit portal vein

1987 • 51 citations

ADP and, indirectly, ATP are potent inhibitors of cAMP production in intact isoproterenol-stimulated C6 glioma cells

1989 • 50 citations

Undifferentiated HL60 cells respond to extracellular ATP and UTP by stimulating phospholipase C activation and exocytosis

1990 • 49 citations

P₂‐Purinoceptor Antagonists^a

1990 • 44 citations

G-protein-mediated activation of turkey erythrocyte phospholipase C by β-adrenergic and P2y-purinergic receptors

1992 • 40 citations

Beta-adrenergic receptor-mediated phospholipase C activation independent of cAMP formation in turkey erythrocyte membranes

1991 • 38 citations

Purine receptors in the guinea‐pig internal anal sphincter

1983 • 33 citations

Endothelin- and ATP-induced inhibition of adenylyl cyclase activity in C6 glioma cells: role of Gi and calcium.

1993 • 27 citations

Pre-steady state study of beta-adrenergic and purinergic receptor interaction in C6 cell membranes: undelayed balance between positive and negative coupling to adenylyl cyclase.

1992 • 21 citations

Reactive blue 2 selectively inhibits P_2y‐purinoceptor‐stimulated surfactant phospholipid secretion from rat isolated alveolar Type II cells

1989 • 21 citations