Phosphorylation and activation of heart PFK-2 by AMPK has a role in the stimulation of glycolysis during ischaemia

Phosphorylation-Dephosphorylation of Enzymes

1979 • 2,205 citations

The AMP‐Activated Protein Kinase

1997 • 1,313 citations

5-Aminoimidazole-4-Carboxamide Ribonucleoside. A Specific Method for Activating AMP-Activated Protein Kinase in Intact Cells?

1995 • 1,163 citations

5-Aminoimidazole-4-Carboxamide Ribonucleoside. A Specific Method for Activating AMP-Activated Protein Kinase in Intact Cells?

1995 • 896 citations

AMP‐activated protein kinase phosphorylation of endothelial NO synthase

1999 • 827 citations

5' AMP-activated protein kinase activation causes GLUT4 translocation in skeletal muscle.

1999 • 719 citations

A Kinetic Study of Pyrophosphate: Fructose‐6‐Phosphate Phosphotransferase from Potato Tubers

1982 • 651 citations

Mammalian AMP-activated Protein Kinase Subfamily

1996 • 631 citations

Characterization of AMP-activated protein kinase γ-subunit isoforms and their role in AMP binding

2000 • 605 citations

The regulation of AMP-activated protein kinase by phosphorylation

2000 • 582 citations

Tissue distribution of the AMP‐activated protein kinase, and lack of activation by cyclic‐AMP‐dependent protein kinase, studied using a specific and sensitive peptide assay

1989 • 437 citations

Phosphorylation and Activation of Heart 6-Phosphofructo-2-kinase by Protein Kinase B and Other Protein Kinases of the Insulin Signaling Cascades

1997 • 435 citations

Role of fructose 2,6-bisphosphate in the control of glycolysis in mammalian tissues

1987 • 423 citations

Purification and characterization of the AMP‐activated protein kinase

1989 • 413 citations

Characterization of the Role of AMP-Activated Protein Kinase in the Regulation of Glucose-Activated Gene Expression Using Constitutively Active and Dominant Negative Forms of the Kinase

2000 • 410 citations

Mammalian AMP-activated protein kinase shares structural and functional homology with the catalytic domain of yeast Snf1 protein kinase.

1994 • 330 citations

Dual regulation of the AMP-activated protein kinase provides a novel mechanism for the control of creatine kinase in skeletal muscle

1998 • 330 citations

The substrate and sequence specificity of the AMP-activated protein kinase. Phosphorylation of glycogen synthase and phosphorylase kinase

1989 • 303 citations

Comparison of the Effects of Anoxia and Whole Heart Ischemia on Carbohydrate Utilization in Isolated Working Rat Hearts

1973 • 293 citations

An inducible gene product for 6-phosphofructo-2-kinase with an AU-rich instability element: Role in tumor cell glycolysis and the Warburg effect

1999 • 281 citations

Glycolytic Control Mechanisms

1966 • 262 citations

The α1 and α2 isoforms of the AMP‐activated protein kinase have similar activities in rat liver but exhibit differences in substrate specificity in vitro

1996 • 260 citations

6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE: A METABOLIC SIGNALING ENZYME

1995 • 254 citations

Inhibition of fatty acid and cholesterol synthesis by stimulation of AMP‐activated protein kinase

1995 • 247 citations

Characterization of AMP-activated Protein Kinase β and γ Subunits

1996 • 236 citations

Inhibition by AICA Riboside of Gluconeogenesis in Isolated Rat Hepatocytes

1991 • 208 citations

Mechanisms of control of heart glycolysis

1998 • 159 citations

Activation of glycogen phosphorylase and glycogenolysis in rat skeletal muscle by AICAR — an activator of AMP‐activated protein kinase

1996 • 143 citations

Protection Against Ischemic Injury by Nonvasoactive Concentrations of Nitric Oxide Synthase Inhibitors in the Perfused Rabbit Heart

1995 • 135 citations

The regulation of AMP-activated protein kinase by phosphorylation

2000 • 128 citations

Characterization of AMP-activated protein kinase γ-subunit isoforms and their role in AMP binding

2000 • 95 citations

Mutations in a GTP-binding Motif of Eukaryotic Elongation Factor 1A Reduce Both Translational Fidelity and the Requirement for Nucleotide Exchange

1999 • 81 citations

Role of fructose 2,6-bisphosphate in the control of heart glycolysis

1993 • 78 citations

Heart 6-Phosphofructo-2-kinase Activation by Insulin Results from Ser-466 and Ser-483 Phosphorylation and Requires 3-Phosphoinositide-dependent Kinase-1, but Not Protein Kinase B

1999 • 73 citations

Role of fructose 2,6-bisphosphate in the stimulation of glycolysis by anoxia in isolated hepatocytes

1982 • 70 citations

Cloning of cDNA Encoding for a Novel Isozyme of Fructose 6-Phosphate,2-Kinase/Fructose 2,6-Bisphosphatase from Human Placenta

1996 • 62 citations

Fructose 2,6-bisphosphate in rat skeletal muscle during contraction

1984 • 43 citations

Cell-type specificity of inhibition of glycolysis by 5-amino-4-imidazolecarboxamide riboside. Lack of effect in rabbit cardiomyocytes and human erythrocytes, and inhibition in FTO-2B rat hepatoma cells

1995 • 37 citations

Rat muscle 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. Study of the kinase domain by site-directed mutagenesis

1993 • 12 citations