Characterization of AMP-activated Protein Kinase β and γ Subunits

Molecular cloning: A laboratory manual

1990 • 85,659 citations

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Experiments in molecular genetics

1972 • 28,260 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

Antibodies, a laboratory manual

1989 • 12,929 citations

Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa

1987 • 11,491 citations

A novel genetic system to detect protein–protein interactions

1989 • 6,022 citations

Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer.

1988 • 4,669 citations

Two differentially regulated mRNAs with different 5′ ends encode secreted and intracellular forms of yeast invertase

1982 • 1,539 citations

Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex

1995 • 1,407 citations

λ ZAP: a bacteriophage λ expression vector within vivoexcision properties

1988 • 1,394 citations

On target with a new mechanism for the regulation of protein phosphorylation

1993 • 901 citations

A Yeast Gene That Is Essential for Release from Glucose Repression Encodes a Protein Kinase

1986 • 688 citations

Association of Protein Kinase A and Protein Phosphatase 2B with a Common Anchoring Protein

1995 • 615 citations

A common bicyclic protein kinase cascade inactivates the regulatory enzymes of fatty acid and cholesterol biosynthesis

1987 • 569 citations

MUTANTS OF YEAST DEFECTIVE IN SUCROSE UTILIZATION

1981 • 476 citations

5′-AMP Activates the AMP-activated Protein Kinase Cascade, and Ca2+/Calmodulin Activates the Calmodulin-dependent Protein Kinase I Cascade, via Three Independent Mechanisms

1995 • 440 citations

Role of the AMP-activated protein kinase in the cellular stress response

1994 • 430 citations

Purification and characterization of the AMP‐activated protein kinase

1989 • 413 citations

Yeast SNF1 is functionally related to mammalian AMP-activated protein kinase and regulates acetyl-CoA carboxylase in vivo.

1994 • 388 citations

Carbon catabolite repression in yeast

1992 • 365 citations

Mammalian AMP-activated protein kinase shares structural and functional homology with the catalytic domain of yeast Snf1 protein kinase.

1994 • 330 citations

The substrate and sequence specificity of the AMP-activated protein kinase. Phosphorylation of glycogen synthase and phosphorylase kinase

1989 • 303 citations

Mammalian AMP-activated protein kinase is homologous to yeast and plant protein kinases involved in the regulation of carbon metabolism

1994 • 251 citations

Alternative mechanisms of CAK assembly require an assembly factor or an Activating Kinase

1995 • 238 citations

Mutational analysis of the Saccharomyces cerevisiae SNF1 protein kinase and evidence for functional interaction with the SNF4 protein.

1989 • 236 citations

MAT1 (‘menage à trois’) a new RING finger protein subunit stabilizing cyclin H-cdk7 complexes in starfish and Xenopus CAK.

1995 • 235 citations

Evidence that AMP triggers phosphorylation as well as direct allosteric activation of rat liver AMP‐activated protein kinase

1991 • 217 citations

A Protein Kinase Substrate Identified by the Two-Hybrid System

1992 • 216 citations

Molecular analysis of the SNF4 gene of Saccharomyces cerevisiae: evidence for physical association of the SNF4 protein with the SNF1 protein kinase.

1989 • 197 citations

Regulation of fatty acid and cholesterol metabolism by the AMP-activated protein kinase

1992 • 188 citations

The AMP-activated protein kinase: a multisubstrate regulator of lipid metabolism

1989 • 174 citations

Deletion of SNF1 affects the nutrient response of yeast and resembles mutations which activate the adenylate cyclase pathway.

1991 • 168 citations

Purification of the AMP‐activated protein kinase on ATP‐γ‐Sepharose and analysis of its subunit structure

1994 • 161 citations

A family of proteins containing a conserved domain that mediates interaction with the yeast SNF1 protein kinase complex.

1994 • 143 citations

Mammalian 5'-AMP-activated protein kinase non-catalytic subunits are homologs of proteins that interact with yeast Snf1 protein kinase.

1994 • 123 citations

N-terminal mutations modulate yeast SNF1 protein kinase function.

1992 • 121 citations

Roles of the Snf1/Rkin1/AMP-activated protein kinase family in the response to environmental and nutritional stress

1994 • 89 citations

Activation of rat liver AMP‐activated protein kinase by kinase kinase in a purified, reconstituted system

1994 • 85 citations

Characterization of 5′-AMP-Activated Protein Kinase in Human Liver Using Specific Peptide Substrates and the Effects of 5′-AMP Analogues on Enzyme Activity

1994 • 84 citations

Genetic and molecular characterization of GAL83: its interaction and similarities with other genes involved in glucose repression in Saccharomyces cerevisiae.

1993 • 61 citations

The AMP-activated Protein Kinase Gene is Highly Expressed in Rat Skeletal Muscle. Alternative Splicing and Tissue Distribution of the mRNA

1995 • 61 citations

The AMP-activated Protein Kinase Gene is Highly Expressed in Rat Skeletal Muscle. Alternative Splicing and Tissue Distribution of the mRNA

1995 • 53 citations

Ways of coping with stress

1994 • 28 citations