Orexin/Hypocretin Modulates Response of Ventral Tegmental Dopamine Neurons to Prefrontal Activation: Diurnal Influences

The Rat Brain in Stereotaxic Coordinates

1982 • 53,055 citations

AChE-stained horizontal sections of the rat brain in stereotaxic coordinates

1980 • 4,422 citations

Dopamine, learning and motivation

2004 • 3,146 citations

A framework for mesencephalic dopamine systems based on predictive Hebbian learning

1996 • 2,003 citations

Topographical organization of the efferent projections of the medial prefrontal cortex in the rat: An anterograde tract‐tracing study with Phaseolus vulgaris leucoagglutinin

1989 • 1,570 citations

Multiple Dopamine Functions at Different Time Courses

2007 • 1,333 citations

Synaptic plasticity and addiction

2007 • 1,299 citations

A role for lateral hypothalamic orexin neurons in reward seeking

2005 • 1,266 citations

The neural circuit of orexin (hypocretin): maintaining sleep and wakefulness

2007 • 1,177 citations

Drugs of Abuse and Stress Trigger a Common Synaptic Adaptation in Dopamine Neurons

2003 • 1,133 citations

Afferent modulation of dopamine neuron firing differentially regulates tonic and phasic dopamine transmission

2003 • 1,079 citations

Regulation of firing of dopaminergic neurons and control of goal-directed behaviors

2007 • 1,012 citations

Intracellular and extracellular electrophysiology of nigral dopaminergic neurons—1. Identification and characterization

1983 • 925 citations

Projections from the Rat Prefrontal Cortex to the Ventral Tegmental Area: Target Specificity in the Synaptic Associations with Mesoaccumbens and Mesocortical Neurons

2000 • 872 citations

The control of firing pattern in nigral dopamine neurons: single spike firing

1984 • 856 citations

Discharge of Identified Orexin/Hypocretin Neurons across the Sleep-Waking Cycle

2005 • 840 citations

Prefrontal cortical efferents in the rat synapse on unlabeled neuronal targets of catecholamine terminals in the nucleus accumbens septi and on dopamine neurons in the ventral tegmental area

1992 • 832 citations

Behavioral Correlates of Activity in Identified Hypocretin/Orexin Neurons

2005 • 830 citations

Uniform Inhibition of Dopamine Neurons in the Ventral Tegmental Area by Aversive Stimuli

2004 • 778 citations

Phasic excitation of dopamine neurons in ventral VTA by noxious stimuli

2009 • 761 citations

A novel single-cell staining procedure performed in vivo under electrophysiological control: morpho-functional features of juxtacellularly labeled thalamic cells and other central neurons with biocytin or Neurobiotin

1996 • 721 citations

Orexin A in the VTA Is Critical for the Induction of Synaptic Plasticity and Behavioral Sensitization to Cocaine

2006 • 704 citations

Two types of neurone in the rat ventral tegmental area and their synaptic inputs.

1992 • 682 citations

Fos Expression in Orexin Neurons Varies with Behavioral State

2001 • 647 citations

Dopamine neurons encode the better option in rats deciding between differently delayed or sized rewards

2007 • 589 citations

Excitation of Ventral Tegmental Area Dopaminergic and Nondopaminergic Neurons by Orexins/Hypocretins

2003 • 569 citations

Arousal and reward: a dichotomy in orexin function

2006 • 555 citations

The ventral tegmental area revisited: is there an electrophysiological marker for dopaminergic neurons?

2006 • 531 citations

Direct Involvement of Orexinergic Systems in the Activation of the Mesolimbic Dopamine Pathway and Related Behaviors Induced by Morphine

2006 • 501 citations

Anatomical substrates of orexin–dopamine interactions: lateral hypothalamic projections to the ventral tegmental area

2002 • 499 citations

Antidromic identification of dopaminergic and other output neurons of the rat substantia nigra

1978 • 498 citations

Burst firing in midbrain dopaminergic neurons

1997 • 482 citations

Glutamatergic Afferents of the Ventral Tegmental Area in the Rat

2007 • 476 citations

Dopamine Cells Respond to Predicted Events during Classical Conditioning: Evidence for Eligibility Traces in the Reward-Learning Network

2005 • 448 citations

Fluctuation of extracellular hypocretin‐1 (orexin A) levels in the rat in relation to the light–dark cycle and sleep–wake activities

2001 • 441 citations

The hypocretins: Setting the arousal threshold

2002 • 422 citations

Prefrontal cortex regulates burst firing and transmitter release in rat mesolimbic dopamine neurons studied in vivo

1993 • 386 citations

Afferents of the ventral tegmental area in the rat-anatomical substratum for integrative functions

2005 • 380 citations

Lateral hypothalamic orexin/hypocretin neurons: A role in reward-seeking and addiction

2009 • 372 citations

Anatomical Substrates for Glutamate‐Dopamine Interactions

2003 • 366 citations

The Prefrontal Cortex Regulates the Basal Release of Dopamine in the Limbic Striatum: An Effect Mediated by Ventral Tegmental Area

1996 • 365 citations

Orexin A/Hypocretin-1 Selectively Promotes Motivation for Positive Reinforcers

2009 • 339 citations

Release of Hypocretin (Orexin) during Waking and Sleep States

2002 • 335 citations

The laterodorsal tegmentum is essential for burst firing of ventral tegmental area dopamine neurons

2006 • 334 citations

Role of lateral hypothalamic orexin neurons in reward processing and addiction

2008 • 304 citations

Potent excitatory influence of prefrontal cortex activity on noradrenergic locus coeruleus neurons

1998 • 298 citations

Activation of Ventral Tegmental Area Cells by the Bed Nucleus of the Stria Terminalis: A Novel Excitatory Amino Acid Input to Midbrain Dopamine Neurons

2002 • 286 citations

Identification of C1 presympathetic neurons in rat rostral ventrolateral medulla by juxtacellular labeling in vivo

1997 • 282 citations

Burst firing induced in midbrain dopamine neurons by stimulation of the medial prefrontal and anterior cingulate cortices

1988 • 281 citations

Prominent Burst Firing of Dopaminergic Neurons in the Ventral Tegmental Area during Paradoxical Sleep

2006 • 280 citations

Opiate withdrawal-induced hyperactivity of locus coeruleus neurons is substantially mediated by augmented excitatory amino acid input

1991 • 269 citations

Cortical Regulation of Subcortical Dopamine Release: Mediation via the Ventral Tegmental Area

1995 • 260 citations

Glutamatergic and Nonglutamatergic Neurons of the Ventral Tegmental Area Establish Local Synaptic Contacts with Dopaminergic and Nondopaminergic Neurons

2010 • 255 citations

What is reinforced by phasic dopamine signals?

2007 • 254 citations

Orexin Signaling in the Ventral Tegmental Area Is Required for High-Fat Appetite Induced by Opioid Stimulation of the Nucleus Accumbens

2007 • 246 citations

The hypocretin–orexin system regulates cocaine self‐administration via actions on the mesolimbic dopamine system

2009 • 241 citations

Laterodorsal tegmental projections to identified cell populations in the rat ventral tegmental area

2005 • 240 citations

Dopamine-containing neurons in the mammalian central nervous system: Electrophysiology and pharmacology

1988 • 233 citations

Lateral hypothalamic orexin neurons are critically involved in learning to associate an environment with morphine reward

2007 • 198 citations

A Role for Hypocretin (Orexin) in Male Sexual Behavior

2007 • 198 citations

Stimulation of the prefrontal cortex in the rat induces patterns of activity in midbrain dopaminergic neurons which resemble natural burst events

1996 • 187 citations

Hypocretin/Orexin Selectively Increases Dopamine Efflux within the Prefrontal Cortex: Involvement of the Ventral Tegmental Area

2005 • 180 citations

A top-down perspective on dopamine, motivation and memory

2007 • 171 citations

Critical Role for Ventral Tegmental Glutamate in Preference for a Cocaine-Conditioned Environment

2003 • 162 citations

Orexin axons in the rat ventral tegmental area synapse infrequently onto dopamine and γ‐aminobutyric acid neurons

2007 • 150 citations

Electrical stimulation of the prefrontal cortex increases cholecystokinin, glutamate, and dopamine release in the nucleus accumbens: an in vivo microdialysis study in freely moving rats.

1998 • 147 citations

Glutamate receptor subtypes mediate excitatory synaptic currents of dopamine neurons in midbrain slices

1991 • 145 citations

Patterns of cocaine self-administration in rats produced by various access conditions under a discrete trials procedure

2002 • 143 citations

Glutamate-associated plasticity in the ventral tegmental area is necessary for conditioning environmental stimuli with morphine

2004 • 143 citations

The role of hypocretin in driving arousal and goal-oriented behaviors

2009 • 129 citations

Electrical Stimulation of the Prefrontal Cortex Increases Cholecystokinin, Glutamate, and Dopamine Release in the Nucleus Accumbens: anIn VivoMicrodialysis Study in Freely Moving Rats

1998 • 126 citations

Diurnal Variations in Natural and Drug Reward, Mesolimbic Tyrosine Hydroxylase, and Clock Gene Expression in the Male Rat

2009 • 123 citations

Amphetamine selectively blocks inhibitory glutamate transmission in dopamine neurons

2001 • 122 citations

Glutamate synaptic inputs to ventral tegmental area neurons in the rat derive primarily from subcortical sources

2007 • 120 citations

Noradrenergic Inhibition of Midbrain Dopamine Neurons

2004 • 112 citations

Functional Implications of Glutamatergic Projections to the Ventral Tegmental Area

2008 • 109 citations

Hypocretin /orexin preferentially activates caudomedial ventral tegmental area dopamine neurons

2008 • 107 citations

A Role for Conditioned Ventral Tegmental Glutamate Release in Cocaine Seeking

2007 • 106 citations

Amphetamine Depresses Excitatory Synaptic Transmission via Serotonin Receptors in the Ventral Tegmental Area

1999 • 102 citations

Circadian Rhythms, the Mesolimbic Dopaminergic Circuit, and Drug Addiction

2007 • 98 citations

Autoreceptor-mediated changes in dopaminergic terminal excitability: Effects of striatal drug infusions

1984 • 92 citations

Novel neurons in ventral tegmental area fire selectively during the active phase of the diurnal cycle

2008 • 91 citations

Expression of D1 receptor mRNA in projections from the forebrain to the ventral tegmental area

1997 • 90 citations

Cannabinoid Receptors in the Bed Nucleus of the Stria Terminalis Control Cortical Excitation of Midbrain Dopamine CellsIn Vivo

2008 • 78 citations

Dissecting motivational circuitry to understand substance abuse

2008 • 75 citations

Ionotropic Glutamate Receptors in the Ventral Tegmental Area Regulate Cocaine-Seeking Behavior in Rats

2005 • 67 citations

Autoreceptor-mediated changes in dopaminergic terminal excitability: Effects of increases in impulse flow

1984 • 66 citations

Increase of Extracellular Glutamate and Expression of Fos‐Like Immunoreactivity in the Ventral Tegmental Area in Response to Electrical Stimulation of the Prefrontal Cortex

1998 • 62 citations

Diencephalic and mesencephalic efferents of the medial prefrontal cortex in the rat: Electrophysiological evidence for the existence of branched axons

1983 • 60 citations

Dopaminergic neurons expressing Fos during waking and paradoxical sleep in the rat

2010 • 32 citations

Effects of Cocaine Administration on VTA Cell Activity in Response to Prefrontal Cortex Stimulation

2002 • 18 citations