Opiate withdrawal-induced hyperactivity of locus coeruleus neurons is substantially mediated by augmented excitatory amino acid input

Cellular and Molecular Mechanisms of Drug Dependence

1988 • 2,094 citations

Nucleus locus ceruleus: new evidence of anatomical and physiological specificity

1983 • 1,877 citations

Inhibition of Morphine Tolerance and Dependence by the NMDA Receptor Antagonist MK-801

1991 • 1,212 citations

Norepinephrine-containing locus coeruleus neurons in behaving rats exhibit pronounced responses to non-noxious environmental stimuli.

1981 • 974 citations

Functional comparison of neurotransmitter receptor subtypes in mammalian central nervous system

1990 • 872 citations

Tolerance of locus coeruleus neurones to morphine and suppression of withdrawal response by clonidine

1978 • 794 citations

The Brain Nucleus Locus Coeruleus: Restricted Afferent Control of a Broad Efferent Network

1986 • 763 citations

CLONIDINE BLOCKS ACUTE OPIATE-WITHDRAWAL SYMPTOMS

1978 • 705 citations

Noradrenergic neurons of the locus coeruleus: inhibition by epinephrine and activation by the α-antagonist piperoxane

1976 • 638 citations

Mu and delta receptors belong to a family of receptors that are coupled to potassium channels.

1987 • 616 citations

Dopamine acts on D2 receptors to increase potassium conductance in neurones of the rat substantia nigra zona compacta.

1987 • 611 citations

Discharge of noradrenergic locus coeruleus neurons in behaving rats and monkeys suggests a role in vigilance

1991 • 575 citations

Afferent regulation of locus coeruleus neurons: anatomy, physiology and pharmacology

1991 • 536 citations

Opiate withdrawal and the rat locus coeruleus: behavioral, electrophysiological, and biochemical correlates

1990 • 442 citations

Activation of locus coeruleus from nucleus paragigantocellularis: a new excitatory amino acid pathway in brain

1988 • 342 citations

Naloxone as a GABA antagonist: Evidence from iontophoretic, receptor binding and convulsant studies

1978 • 330 citations

Opiate Withdrawal Using Clonidine

1980 • 319 citations

Acute and chronic opiate-regulation of adenylate cyclase in brain: specific effects in locus coeruleus.

1988 • 280 citations

Cellular mechanisms of opioid tolerance: studies in single brain neurons.

1987 • 260 citations

A potent excitatory input to the nucleus locus coeruleus from the ventrolateral medulla

1986 • 235 citations

ACh, substance P and met-enkephalin in the locus coeruleus: Pharmacological evidence for independent sites of action

1979 • 230 citations

Chronic morphine treatment increases cyclic AMP-dependent protein kinase activity in the rat locus coeruleus.

1988 • 228 citations

Regulation of G proteins by chronic morphine in the rat locus coeruleus

1989 • 209 citations

Noradrenaline‐mediated synaptic inhibition in rat locus coeruleus neurones.

1983 • 202 citations

Effect of glutamate, aspartate and related derivatives on cerebellar Purkinje cell dendrites in the rat: an in vitro study

1982 • 198 citations

Withdrawal-induced activation of locus coeruleus neurons in opiate-dependent rats: attenuation by lesions of the nucleus paragigantocellularis

1989 • 196 citations

Serotonin selectively attenuates glutamate-evoked activation of noradrenergic locus coeruleus neurons

1991 • 181 citations

The contribution of nucleus reticularis paragigantocellularis and nucleus raphe magnus to the analgesia produced by systemically administered morphine, investigated with the microinjection technique

1982 • 181 citations

Distribution-free statistics: an application-oriented approach

1991 • 180 citations

GABA-mediated inhibition of locus coeruleus from the dorsomedial rostral medulla

1989 • 178 citations

Actions of acetylcholine and nicotine on rat locus coeruleus neurons in vitro

1986 • 169 citations

Morphine tolerance and dependence in the locus coeruleus: Single cell studies in brain slices

1983 • 139 citations

Real-time imaging of calcium influx in mammalian cerebellar Purkinje cells in vitro.

1990 • 128 citations

Identification of morphine- and cyclic AMP-regulated phosphoproteins (MARPPs) in the locus coeruleus and other regions of rat brain: regulation by acute and chronic morphine

1989 • 122 citations

Glutamate antagonists prevent morphine withdrawal in mice and guinea pigs

1991 • 116 citations

Projections of nucleus paragigantocellularis lateralis to locus coeruleus and other structures in rat

1987 • 112 citations

Serotonin agonists inhibit synaptic potentials in the rat locus ceruleus in vitro via 5-hydroxytryptamine1A and 5-hydroxytryptamine1B receptors.

1989 • 107 citations

Modulation of tyrosine hydroxylase gene expression in the central nervous system visualized by in situ hybridization.

1987 • 89 citations

Identification of MARPP-58, a morphine- and cyclic AMP-regulated phosphoprotein of 58 kDa, as tyrosine hydroxylase: evidence for regulation of its expression by chronic morphine in the rat locus coeruleus

1990 • 87 citations

Potent inhibitory input to locus coeruleus from the nucleus prepositus hypoglossi

1989 • 86 citations

Sensitivity of Purkinje cell dendrites to glutamic acid

1975 • 81 citations

Development of rat cerebellar Purkinje cells: electrophysiological properties following acute isolation and in long-term culture

1989 • 79 citations

Synaptic potentials in rat locus coeruleus neurones.

1988 • 74 citations

Adrenergic innervation of the rat nucleus locus coeruleus arises predominantly from the C1 adrenergic cell group in the rostral medulla

1991 • 73 citations

Cat spinal motoneurons exhibit topographic sensitivity to glutamate and glycine

1979 • 54 citations

Tolerance and dependence after continuous morphine infusion from osmotic pumps measured by operant responding in rats

1990 • 54 citations

Evidence that the substantia nigra is a component of the endogenous pain suppression system in the rat

1988 • 48 citations

Anatomical evidence for multiple pathways leading from the rostral ventrolateral medulla (nucleus paragigantocellularis) to the locus coeruleus in rat

1990 • 44 citations

Clonidine attenuates increased brain glucose metabolism during naloxone-precipitated morphine withdrawal

1990 • 37 citations

Morphine withdrawal responses of rat locus coeruleus neurons are blocked by an excitatory amino‐acid antagonist

1990 • 36 citations

Failure to block responses of locus coeruleus neurons to somatosensory stimuli by destruction of two major afferent nuclei

1989 • 28 citations

Excitation of locus coeruleus neurons by vasoactive intestinal peptide: evidence for a G-protein-mediated inward current

1989 • 26 citations

Local infusion of calcium-free solutions in vivo activates locus coeruleus neurons

1991 • 20 citations

Clonidine blocks acute opiate-withdrawal symptoms

1979 • 19 citations

Identification of MARPP(14–20), morphine- and cyclic AMP-regulated phosphoproteins of 14–20 kDa, as myelin basic proteins: evidence for their acute and chronic regulation by morphine in rat brain

1990 • 19 citations

Neurophysiological and Neuropharmacological Effects of Opiates

2015 • 2 citations