Mapping of punctuate hyperalgesia around a surgical incision demonstrates that ketamine is a powerful suppressor of central sensitization to pain following surgery

Contribution of central neuroplasticity to pathological pain: review of clinical and experimental evidence

1993 • 2,006 citations

The induction and maintenance of central sensitization is dependent on N -methyl-d-aspartic acid receptor activation; implications for the treatment of post-injury pain hypersensitivity states

1991 • 1,963 citations

Preemptive Analgesia—Treating Postoperative Pain by Preventing the Establishment of Central Sensitization

1993 • 1,661 citations

The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurones by N‐methyl‐aspartate

1983 • 1,400 citations

Evidence for a role of the NMDA receptor in the frequency dependent potentiation of deep rat dorsal horn nociceptive neurones following c fibre stimulation.

1987 • 836 citations

Mechanisms of hyperalgesian and morphine tolerance: a current view of their possible interactions

1995 • 828 citations

Evidence for involvement ofN-methylaspartate receptors in ‘wind-up’ of class 2 neurones in the dorsal horn of the rat

1987 • 666 citations

Relative effectiveness of C primary afferent fibers of different origins in evoking a prolonged facilitation of the flexor reflex in the rat

1986 • 561 citations

Relief of post-herpetic neuralgia with the Symbol receptor antagonist ketamine: A double-blind, cross-over comparison with morphine and placebo

1994 • 483 citations

Clinical Trials

1986 • 480 citations

Effects of ketamine on sensory perception: evidence for a role of N-methyl-D-aspartate receptors.

1992 • 412 citations

Long-Term Postthoracotomy Pain

1991 • 354 citations

PHARMACOKINETICS AND ANALGESIC EFFECTS OF I.M. AND ORAL KETAMINE

1981 • 346 citations

The Effect of N-Methyl-D-aspartate Antagonist (Ketamine) on Single and Repeated Nociceptive Stimuli

1995 • 279 citations

Preemptive Effect of Fentanyl and Ketamine on Postoperative Pain and Wound Hyperalgesia

1994 • 275 citations

Preoperative morphine pre-empts postoperative pain

1993 • 275 citations

Dynamic alterations in the cutaneous mechanoreceptive fields of dorsal horn neurons in the rat spinal cord

1990 • 272 citations

Continuous subcutaneous administration of the N -methyl-D-aspartic acid (NMDA) receptor antagonist ketamine in the treatment of post-herpetic neuralgia

1995 • 263 citations

Postoperative Pain

1993 • 247 citations

Pain after thoracic surgery

1992 • 223 citations

Intrathecal ketamine reduces morphine requirements in patients with terminal cancer pain

1996 • 205 citations

Comparison of morphine and morphine with ketamine for postoperative analgesia

1996 • 201 citations

The combination of NMDA antagonism and morphine produces profound antinociception in the rat dorsal horn

1992 • 200 citations

Ketamine

1985 • 193 citations

Status of Ketamine in Anesthesiology.

1992 • 139 citations

Temporal relationships between changes in phantom limb pain intensity and changes in surface electromyogram of the residual limb

1992 • 90 citations

Is there any clinical advantage of increasing the pre-emptive dose of morphine or combining pre-incisional with postoperative morphine administration?

1995 • 60 citations

Ketamine as an adjunct to morphine in the treatment of pain

1995 • 54 citations

Douleurs cancéreuses : effet bénéfique de l'adjonction de kétamine au mélange morphine-clonidine-lidocaïne administré par voie intrathécale

1996 • 30 citations

9 Post-operative analgesic trials: some important issues

1995 • 18 citations

8 The NMDA-antagonist ketamine for prevention and treatment of acute and chronic post-operative pain

1995 • 16 citations