The yeast SIN3 gene product negatively regulates the activity of the human progesterone receptor and positively regulates the activities of GAL4 and the HAP1 activator

Experiments in molecular genetics

1972 • 28,260 citations

Transformation of intact yeast cells treated with alkali cations

1983 • 7,688 citations

Gene regulation by steroid hormones

1989 • 3,466 citations

How eukaryotic transcriptional activators work

1988 • 1,924 citations

Mechanism of transcriptional activation by Sp1: Evidence for coactivators

1990 • 1,029 citations

Functional domains of the human glucocorticoid receptor

1986 • 933 citations

Transcriptional regulation

1991 • 893 citations

Gene regulation by proteins acting nearby and at a distance

1986 • 886 citations

Steroid Receptor Family: Structure and Functions

1990 • 820 citations

Multiple and cooperative trans-activation domains of the human glucocorticoid receptor

1988 • 705 citations

Sequence-specific binding of glucocorticoid receptor to MTV DNA at sites within and upstream of the transcribed region

1983 • 700 citations

Ssn6-Tup1 is a general repressor of transcription in yeast

1992 • 680 citations

Activators and targets

1990 • 582 citations

A GAL10-CYC1 hybrid yeast promoter identifies the GAL4 regulatory region as an upstream site.

1982 • 575 citations

Distinctly regulated tandem upstream activation sites mediate catabolite repression of the CYC1 gene of S. cerevisiae

1984 • 501 citations

MINIREVIEW: The Steroid Receptor Superfamily: More Excitement Predicted for the Future

1990 • 489 citations

Roles of SWI1, SWI2, and SWI3 Proteins for Transcriptional Enhancement by Steroid Receptors

1992 • 477 citations

Genetic isolation of ADA2: A potential transcriptional adaptor required for function of certain acidic activation domains

1992 • 446 citations

Nucleosome positioning modulates accessibility of regulatory proteins to the mouse mammary tumor virus promoter

1990 • 440 citations

Acid blobs and negative noodles

1988 • 438 citations

The human oestrogen receptor functions in yeast

1988 • 402 citations

The formation and function of DNase I hypersensitive sites in the process of gene activation.

1988 • 394 citations

The mechanism of RU486 antagonism is dependent on the conformation of the carboxy-terminal tail of the human progesterone receptor

1992 • 381 citations

Regulation of Progesterone Receptor-Mediated Transcription by Phosphorylation

1990 • 365 citations

Defining the Sequence Specificity of DNA-Binding Proteins by Selecting Binding Sites from Random-Sequence Oligonucleotides: Analysis of Yeast GCN4 Protein

1989 • 333 citations

Commitment and activation at pol II promoters: A tail of protein-protein interactions

1990 • 332 citations

Structural and functional characterization of the short acidic transcriptional activation region of yeast GCN4 protein

1988 • 325 citations

Carcinogenesis: A superfamily of potentially oncogenic hormone receptors

1986 • 324 citations

Yeast HAP1 activator binds to two upstream activation sites of different sequence

1987 • 317 citations

A site-specific endonuclease essential for mating-type switching in Saccharomyces cerevisiae

1983 • 302 citations

Role of chromatin structure in the regulation of transcription by RNA polymerase II

1993 • 298 citations

An amino-terminal fragment of GAL4 binds DNA as a dimer

1989 • 296 citations

Activation of the yeast HO gene by release from multiple negative controls

1987 • 257 citations

Molecular Cloning of the Chicken Progesterone Receptor

1986 • 243 citations

A nucleosome-dependent static loop potentiates estrogen-regulated transcription from the Xenopus vitellogenin B1 promoter in vitro.

1993 • 219 citations

Defining the sequence specificity of DNA-binding proteins by selecting binding sites from random-sequence oligonucleotides: analysis of yeast GCN4 protein.

1989 • 207 citations

Differential gene activation by glucocorticoids and progestins through the hormone regulatory element of mouse mammary tumor virus

1988 • 205 citations

Potentiation of RNA polymerase II transcription by Gal4-VP16 during but not after DNA replication and chromatin assembly.

1993 • 191 citations

Largest subunit of Drosophila transcription factor IID directs assembly of a complex containing TBP and a coactivator

1993 • 176 citations

Both positive and negative regulators of HO transcription are required for mother-cell-specific mating-type switching in yeast

1987 • 171 citations

RPD1 (SIN3/UME4) is required for maximal activation and repression of diverse yeast genes.

1991 • 168 citations

Yeast alpha 2 repressor positions nucleosomes in TRP1/ARS1 chromatin.

1990 • 161 citations

The Saccharomyces cerevisiae SIN3 gene, a negative regulator of HO, contains four paired amphipathic helix motifs.

1990 • 156 citations

A functional role for nucleosomes in the repression of a yeast promoter.

1991 • 156 citations

A synthetic HIS4 regulatory element confers general amino acid control on the cytochrome c gene (CYC1) of yeast.

1985 • 144 citations

High level expression of biologically active estrogen receptor in Saccharomyces cerevisiae

1991 • 141 citations

Transcriptional repression in Saccharomyces cerevisiae by a SIN3-LexA fusion protein.

1993 • 111 citations

Expression of Functional Chicken Oviduct Progesterone Receptors in Yeast (Saccharomyces Cerevisiae)

1989 • 111 citations

GAL4 disrupts a repressing nucleosome during activation of GAL1 transcription in vivo.

1993 • 109 citations

Characterization and Functional Properties of the A and B Forms of Human Progesterone Receptors Synthesized in a Baculovirus System

1991 • 105 citations

Poising chromatin for transcription

1987 • 103 citations

Regulating the HO endonuclease in yeast

1993 • 99 citations

Identification of a negative regulatory function for steroid receptors.

1992 • 98 citations

RPD1 (SIN3/UME4) Is Required for Maximal Activation and Repression of Diverse Yeast Genes

1991 • 61 citations

Structure-Function Properties of the Chicken Progesterone Receptor A Synthesized from Complementary Deoxyribonucleic Acid

1987 • 60 citations

TheSaccharomyces cerevisiae GAM2/SIN3 protein plays a role in both activation and repression of transcription

1992 • 54 citations

Transcriptional Repression in Saccharomyces cerevisiae by a SIN3-LexA Fusion Protein

1993 • 41 citations

The Saccharomyces cerevisiae SIN3 Gene, a Negative Regulator of HO, Contains Four Paired Amphipathic Helix Motifs

1990 • 39 citations

36 Integration of Multiple Regulatory Inputs in the Control of HO Expression in Yeast

1992 • 29 citations

Activator's target in sight

1989 • 28 citations

Genetic interactions between SIN3 mutations and the Saccharomyces cerevisiae transcriptional activators encoded by MCM1, STE12, and SWI1

1994 • 24 citations

Identification of novel steroid-response elements.

1992 • 20 citations

Protein-DNA Interactions at Steroid Hormone Regulated Genes

1989 • 15 citations