Of Mice and MEN1: Insulinomas in a Conditional Mouse Knockout

High resolution analysis of DNA copy number variation using comparative genomic hybridization to microarrays

1998 • 2,266 citations

Positional Cloning of the Gene for Multiple Endocrine Neoplasia-Type 1

1997 • 2,009 citations

Dual Roles for Glucokinase in Glucose Homeostasis as Determined by Liver and Pancreatic β Cell-specific Gene Knock-outs Using Cre Recombinase

1999 • 1,284 citations

Multiple endocrine neoplasia type 1 gene maps to chromosome 11 and is lost in insulinoma

1988 • 1,022 citations

β-Cell-specific inactivation of the mouseIpf1/Pdx1 gene results in loss of the β-cell phenotype and maturity onset diabetes

1998 • 901 citations

Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in β-islet cell hyperplasia

1999 • 693 citations

Targeted oncogene activation by site-specific recombination in transgenic mice.

1992 • 687 citations

Menin Interacts with the AP1 Transcription Factor JunD and Represses JunD-Activated Transcription

1999 • 611 citations

Z/AP, a Double Reporter for Cre-Mediated Recombination

1999 • 539 citations

A mouse model of multiple endocrine neoplasia, type 1, develops multiple endocrine tumors

2001 • 453 citations

Characterization of Mutations in Patients with Multiple Endocrine Neoplasia Type 1

1998 • 436 citations

Menin, the product of the MEN1 gene, is a nuclear protein

1998 • 426 citations

Somatic mutation of the MEN1 gene in parathyroid tumours

1997 • 403 citations

VEGF-A has a critical, nonredundant role in angiogenic switching and pancreatic β cell carcinogenesis

2002 • 372 citations

Genome scanning with array CGH delineates regional alterations in mouse islet carcinomas

2001 • 305 citations

Somatic mutations of the MEN1 tumor suppressor gene in sporadic gastrinomas and insulinomas.

1997 • 293 citations

Inactivation of menin, a Smad3-interacting protein, blocks transforming growth factor type β signaling

2001 • 291 citations

Functional Collaboration between Different Cyclin-Dependent Kinase Inhibitors Suppresses Tumor Growth with Distinct Tissue Specificity

2000 • 289 citations

Identification of MEN1 gene mutations in sporadic carcinoid tumors of the lung

1997 • 248 citations

The tumor suppressor protein menin interacts with NF-κB proteins and inhibits NF-κB-mediated transactivation

2001 • 247 citations

Mutations of the MEN1 tumor suppressor gene in pituitary tumors.

1997 • 241 citations

Germ Line Transmission of the Cdk4^R24C Mutation Facilitates Tumorigenesis and Escape from Cellular Senescence

2002 • 167 citations

Alterations of theMEN1Gene in Sporadic Parathyroid Tumors1

1998 • 166 citations

Characterization of the mouse Men1 gene and its expression during development

1998 • 137 citations

The 32-Kilodalton Subunit of Replication Protein A Interacts with Menin, the Product of the MEN1 Tumor Suppressor Gene

2003 • 122 citations

Menin Interacts Directly with the Homeobox-Containing Protein Pem

2001 • 96 citations

Mutation analysis of the MEN1 gene in Belgian patients with multiple endocrine neoplasia type 1 and related diseases

1999 • 95 citations

Centrosome abnormalities, recurring deletions of chromosome 4, and genomic amplification of HER2/neu define mouse mammary gland adenocarcinomas induced by mutant HER2/neu

2002 • 94 citations

Menin, a Gene Product Responsible for Multiple Endocrine Neoplasia Type 1, Interacts with the Putative Tumor Metastasis Suppressor nm23

2001 • 91 citations

Genome-wide search for loss of heterozygosity in transgenic mouse tumors reveals candidate tumor suppressor genes on chromosomes 9 and 16.

1994 • 73 citations

Isolation, genomic organization, and expression analysis of Men1, the murine homolog of the MEN1 gene

1999 • 71 citations

Methods of Antigen Recovery Vary in Their Usefulness in Unmasking Specific Antigens in Immunohistochemistry

2000 • 68 citations

Tumor Cells Utilize Multiple Pathways to Down‐modulate Apoptosis: Lessons from a Mouse Model of Islet Cell Carcinogenesis

1999 • 46 citations

Analysis of recurrent germline mutations in theMEN1 gene encountered in apparently unrelated families

1998 • 41 citations