Hyperosmotically Induced Volume Change and Calcium Signaling in Intervertebral Disk Cells: The Role of the Actin Cytoskeleton

The human lumbar intervertebral disc: evidence for changes in the biosynthesis and denaturation of the extracellular matrix with growth, maturation, ageing, and degeneration.

1996 • 985 citations

Action of cytochalasin D on cytoskeletal networks.

1982 • 581 citations

Membrane Mechanisms and Intracellular Signalling in Cell Volume Regulation

1995 • 469 citations

Cellular Tensegrity: Exploring How Mechanical Changes in the Cytoskeleton Regulate Cell Growth, Migration, and Tissue Pattern during Morphogenesis

1994 • 428 citations

Biochemistry of the Intervertebral Disc

1979 • 386 citations

Application of the Micropipette Technique to the Measurement of Cultured Porcine Aortic Endothelial Cell Viscoelastic Properties

1990 • 371 citations

Calcium signaling in cell volume regulation

1992 • 349 citations

Water transport across mammalian cell membranes

1996 • 329 citations

The Diversity of Volume Regulatory Mechanisms

1998 • 310 citations

Signalling in the Yeasts: An Informational Cascade with Links to the Filamentous Fungi

1998 • 298 citations

Ultrastructureofthe human intervertebral disc. I. Changes in notochordal cells with age

1982 • 253 citations

The Effects of Osmotic Stress on the Viscoelastic and Physical Properties of Articular Chondrocytes

2002 • 246 citations

Viscoelastic properties of chondrocytes from normal and osteoarthritic human cartilage

2000 • 246 citations

Physiological significance of volume-regulatory transporters

1999 • 244 citations

Ratiometric confocal Ca2+-measurements with visible wavelength indicators in isolated cardiac myocytes

1993 • 244 citations

Initial characterization of the metabolism of intervertebral disc cells encapsulated in microspheres

1992 • 215 citations

Proteoglycan synthesis in the intervertebral disk nucleus: the role of extracellular osmolality

1997 • 208 citations

Effect of sustained loading on the water content of intervertebral discs: implications for disc metabolism.

1996 • 187 citations

The cytoskeleton of the vertebrate smooth muscle cell

1998 • 185 citations

The role of the cortical cytoskeleton: F-actin crosslinking proteins protect against osmotic stress, ensure cell size, cell shape and motility, and contribute to phagocytosis and development

1996 • 161 citations

Effect of static load on matrix synthesis rates in the intervertebral disc measured in vitro by a new perfusion technique

1995 • 159 citations

Mechanical Interactions Among Cytoskeletal Filaments

1998 • 151 citations

The actin cytoskeleton in store‐mediated calcium entry

2000 • 143 citations

Collagen gene expression and mechanical properties of intervertebral disc cell–alginate cultures

2001 • 140 citations

Water Diffusion Pathway, Swelling Pressure, and Biomechanical Properties of the Intervertebral Disc During Compression Load

1989 • 134 citations

Characterisation of cytoplasm‐filled processes in cells of the intervertebral disc

1998 • 131 citations

Hyper-osmotic stress induces volume change and calcium transients in chondrocytes by transmembrane, phospholipid, and G-protein pathways

2001 • 130 citations

Intervertebral Disc Cells Exhibit Differences in Gene Expression in Alginate and Monolayer Culture

2001 • 124 citations

Micromechanics and ultrastructure of actin filament networks crosslinked by human fascin: A comparison with α-actinin

2001 • 123 citations

The osmotic sensitivity of isolated and in situ bovine articular chondrocytes

2001 • 119 citations

Viscoelastic Properties of Intervertebral Disc Cells

1999 • 114 citations

Role of actin filament organization in cell volume and ion channel regulation

1997 • 113 citations

Passive mechanical behavior of human neutrophils: effect of cytochalasin B

1994 • 112 citations

Calcium-dependent activation of Erk-1 and Erk-2 after hypo-osmotic astrocyte swelling

1996 • 104 citations

An In Vivo Magnetic Resonance Imaging Study of Changes in the Volume (and Fluid Content) of the Lumbar Intervertebral Discs During a Simulated Diurnal Load Cycle

1999 • 96 citations

Hydrogen peroxide induces apoptosis of chondrocytes; involvement of calcium ion and extracellular signal-regulated protein kinase

2001 • 92 citations

Calcium as a versatile second messenger in the control of gene expression

1999 • 86 citations

Diurnal fluid changes of lumbar discs measured indirectly by magnetic resonance imaging

1994 • 76 citations

Relationships between the actin cytoskeleton and cell volume regulation

1999 • 74 citations

Actin Polymerisation Regulates Integrin-Mediated Adhesion as Well as Rigidity of Neutrophils

1997 • 71 citations

Comparison of the viscoelastic properties of normal hepatocytes and hepatocellular carcinoma cells under cytoskeletal perturbation

2000 • 69 citations

Microvillar Ca++ signaling: A new view of an old problem

1999 • 69 citations

Changes in cytoskeletal actin content, F-actin distribution, and surface morphology during HL-60 cell volume regulation

1996 • 68 citations

Effect of cytochalasin D on the mechanical properties and morphology of passive human neutrophils

1995 • 60 citations

Pathways for K+ transport across the bovine articular chondrocyte membrane and their sensitivity to cell volume

1996 • 55 citations

Regulation of cell volume and [Ca2+]i in attached human fibroblasts responding to anisosmotic buffers

1994 • 54 citations

Effects of Continuous Quantitative Vibration on Rheologic and Biological Behaviors of the Intervertebral Disc

1992 • 53 citations

A method for quantifying cell size from differential interference contrast images: validation and application to osmotically stressed chondrocytes

2002 • 53 citations

Calcium storage and release properties of F‐actin: evidence for the involvement of F‐actin in cellular calcium signaling

1996 • 52 citations

Molecular basis of renal disease. Mechanisms and clinical significance of cell volume regulation

1998 • 50 citations

Cell volume regulation: the role of taurine loss in maintaining membrane potential and cell pH

2000 • 48 citations

Organic osmolyte channels in cell volume regulation in vertebrates

1999 • 47 citations

Regulation of cell volume via microvillar ion channels

2000 • 46 citations

A Hyperosmotic Stimulus Elevates Intracellular Calcium and Inhibits Proliferation of a Human Keratinocyte Cell Line

2000 • 42 citations

Organic osmolyte channels in cell volume regulation in vertebrates

1999 • 37 citations

The Cytoskeleton in Cell Volume Regulation

1998 • 34 citations

Actin filament annealing in the presence of ATP and phalloidin

1993 • 33 citations

Ca‐dependent regulation of Na⁺‐selective channels via actin cytoskeleton modification in leukemia cells

1997 • 32 citations

Optical evaluation of red blood cell geometry using micropipette aspiration.

1992 • 28 citations

A Hyperosmotic Stimulus Regulates Intracellular pH, Calcium, and S-100 Protein Levels in Avian Chondrocytes

1996 • 27 citations

Stabilization of actin by phalloidin: A differential scanning calorimetric study

1991 • 25 citations

Barrier effects of hyperosmolar signaling in microvascular endothelium of rat lung.

1997 • 25 citations

Ca²⁺ and p38 MAP kinase regulate mAChR-mediated c-Fos expression in avian exocrine cells

2000 • 17 citations

Compatible Organic Osmolytes and Osmotic Modulation of Inducible Nitric Oxide Synthetase in RAW 264.7 Mouse Macrophages

1998 • 16 citations

Effect of plasma osmolality on steady-state fluid shifts in perfused cat skeletal muscle

1993 • 12 citations

Influence of phalloidin on both the nucleation and the elongation phase of actin polymerization

1987 • 12 citations

Does Actin Polymerization Status Modulate Ca2+Storage in Human Neutrophils? Release and Coalescence of Ca2+Stores by Cytochalasins

1997 • 11 citations

F-actin organization influences the osmotic reactions of animal cells.

1989 • 5 citations

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