The human lumbar intervertebral disc: evidence for changes in the biosynthesis and denaturation of the extracellular matrix with growth, maturation, ageing, and degeneration.

Improved quantitation and discrimination of sulphated glycosaminoglycans by use of dimethylmethylene blue

1986 • 3,282 citations

Aging and Degeneration of the Human Intervertebral Disc

1995 • 1,263 citations

Preliminary Evaluation of a Scheme for Grading the Gross Morphology of the Human Intervertebral Disc

1990 • 841 citations

Increased damage to type II collagen in osteoarthritic articular cartilage detected by a new immunoassay.

1994 • 611 citations

The Biosynthesis of Collagen and Its Disorders

1979 • 573 citations

Nutrition of the Intervertebral Disc: Solute Transport and Metabolism

1981 • 511 citations

The tensile properties of the cartilage of human femoral condyles related to the content of collagen and glycosaminoglycans

1973 • 448 citations

Cathepsin B1. A lysosomal enzyme that degrades native collagen

1974 • 405 citations

Biochemistry of the Intervertebral Disc

1979 • 386 citations

Procollagen type I carboxy-terminal extension peptide in serum as a marker of collagen biosynthesis in bone. Correlation with iliac bone formation rates and comparison with total alkaline phosphatase

1987 • 339 citations

Production and characterization of monoclonal antibodies directed against connective tissue proteoglycans.

1985 • 321 citations

Types I and II collagens in intervertebral disc. Interchanging radial distributions in annulus fibrosus

1976 • 314 citations

Quantitative analysis of types I and II collagens in human intervertebral discs at various ages

1977 • 306 citations

Immunohistochemical detection and immunochemical analysis of type II collagen degradation in human normal, rheumatoid, and osteoarthritic articular cartilages and in explants of bovine articular cartilage cultured with interleukin 1.

1989 • 298 citations

Effects of proteoglycan extraction on the tensile behavior of articular cartilage

1990 • 292 citations

Degeneration and the chemical composition of the human lumbar intervertebral disc

1987 • 281 citations

Cartilage in health and disease

1997 • 270 citations

Collagen: Structure, function, and metabolism in normal and fibrotic tissues

1983 • 264 citations

Studies of the articular cartilage proteoglycan aggrecan in health and osteoarthritis. Evidence for molecular heterogeneity and extensive molecular changes in disease.

1992 • 250 citations

Cartilage and bone metabolism in rheumatoid arthritis. Differences between rapid and slow progression of disease identified by serum markers of cartilage metabolism.

1995 • 244 citations

Independent expression of fibril-forming collagens I, II, and III in chondrocytes of human osteoarthritic cartilage.

1993 • 236 citations

The Effect of Lactate and pH on Proteoglycan and Protein Synthesis Rates in the Intervertebral Disc

1992 • 229 citations

Intradiscal Measurements of pH in Patients with Lumbar Rhizopathies

1969 • 196 citations

Age-Related Variations in Proteinpolysaccharides from Human Nucleus Pulposus, Annulus Fibrosus, and Costal Cartilage

1969 • 162 citations

The Human Lumbar Endplate

1996 • 151 citations

Correlation between lactate levels and pH in discs of patients with lumbar rhizopathies

1968 • 144 citations

Lymph and blood supply of the human intervertebral disc: Cadaver study of correlations to discitis

1993 • 142 citations

The measurement of fixed charged density in the intervertebral disc

1979 • 124 citations

The extracellular matrix of cartilage in the growth plate before and during calcification: Changes in composition and degradation of type II collagen

1992 • 118 citations

Magnetic resonance imaging reflects the chemical changes of aging degeneration in the human intervertebral disk.

1991 • 100 citations

Changes in Endplate Vascularity After an Outer Anulus Tear in the Sheep

1992 • 94 citations

Age-related changes in protein-related epitopes of human articular-cartilage proteoglycans

1986 • 90 citations

The calcification of cartilage matrix in chondrocyte culture: studies of the C-propeptide of type II collagen (chondrocalcin).

1987 • 88 citations

Proteoglycan Chemistry of the Intervertebral Disks

1977 • 73 citations

Variations of the proteoglycans of the canine intervertebral disc with ageing

1986 • 70 citations

Chymopapain, Chemonucleolysis, and Nucleus Pulposus Regeneration A Biochemical and Biomechanical Study

1984 • 65 citations

Chemical and metabolic heterogeneity of chondroitin sulfate and keratan sulfate in guinea pig cartilage and nucleus pulposus

1973 • 62 citations

Immunochemical markers of joint inflammation, skeletal damage and repair: where are we now?

1994 • 54 citations

Enhanced denaturation of the α1(II) chains of type‐II collagen in normal adult human intervertebral discs compared with femoral articular cartilage

1996 • 54 citations

BODY FLUID MARKERS OF CARTILAGE CHANGES IN OSTEOARTHRITIS

1993 • 53 citations

The proteoglycans of the canine intervertebral disc

1985 • 51 citations

Long-term Effects of Chymopapain on Intervertebral Disks of Dogs

1973 • 40 citations

Molecular markers of processes in cartilage in joint disease.

1991 • 39 citations

Effect of age on the abundance and fragmentation of link protein of the human intervertebral disc

1989 • 35 citations

Biosynthesis and metabolism in vivo of intervertebral-disc proteoglycans in the mouse

1983 • 29 citations

Changes in mouse intervertebral-disc proteoglycan synthesis with age. Hereditary kyphoscoliosis is associated with elevated synthesis

1986 • 18 citations

Proteoglycans of the Intervertebral Disc

2013 • 15 citations

The effect of chymopapain on low back pain.

1992 • 2 citations