Hydrogen peroxide induces apoptosis of chondrocytes; involvement of calcium ion and extracellular signal-regulated protein kinase

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

1995 • 4,003 citations

A synthetic inhibitor of the mitogen-activated protein kinase cascade.

1995 • 2,723 citations

Mitogen-activated protein kinase pathways

1997 • 2,513 citations

Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice

1996 • 1,902 citations

Redox Regulation of Cellular Signalling

1999 • 1,146 citations

Inhibition of MAP Kinase Kinase Blocks the Differentiation of PC-12 Cells Induced by Nerve Growth Factor

1995 • 906 citations

Oxidative stress activates extracellular signal-regulated kinases through Src and Ras in cultured cardiac myocytes of neonatal rats.

1997 • 683 citations

Dual regulation of caspase activity by hydrogen peroxide: implications for apoptosis

1997 • 663 citations

Signaling Pathways in Reactive Oxygen Species–Induced Cardiomyocyte Apoptosis

1999 • 574 citations

Linkage of chondrocyte apoptosis and cartilage degradation in human osteoarthritis

1998 • 498 citations

Hydrogen peroxide-induced apoptosis is CD95-independent, requires the release of mitochondria-derived reactive oxygen species and the activation of NF-κB

1999 • 319 citations

The apoptosis cascade -- morphological and immunohistochemical methods for its visualization

1999 • 316 citations

PROTEOLYTIC ACTIVITIES THAT MEDIATE APOPTOSIS

1998 • 282 citations

Destabilization of Raf-1 by Geldanamycin Leads to Disruption of the Raf-1–MEK–Mitogen-Activated Protein Kinase Signalling Pathway

1996 • 274 citations

Reactive oxygen intermediates regulate cellular response to apoptotic stimuli: An hypothesis

1999 • 160 citations

Apoptotic chondrocyte death in rheumatoid arthritis

1999 • 114 citations

Requirement of intracellular calcium mobilization for peroxynitrite-induced poly(ADP-ribose) synthetase activation and cytotoxicity.

1999 • 74 citations

Hyaluronic acid inhibits interleukin-1-induced superoxide anion in bovine chondrocytes

1997 • 71 citations

Concurrent generation of nitric oxide and superoxide inhibits proteoglycan synthesis in bovine articular chondrocytes: involvement of peroxynitrite.

1998 • 61 citations

Effect of hydrogen peroxide on the metabolism of articular chondrocytes

1999 • 51 citations

Histamine H1-receptor-mediated keratan sulfate production in rabbit chondrocytes: involvement of protein kinase C

1991 • 26 citations

Superoxide dismutase inhibits interleukin-1-induced degradation of human cartilage

1994 • 22 citations

Protein Kinase C Modulates the Synthesis of Nitric Oxide by Osteoblasts

1998 • 10 citations