Characterization of PC2, a mammalian Kex2 homologue, following expression of the cDNA in microinjected Xenopus oocytes

Post-Translational Proteolysis in Polypeptide Hormone Biosynthesis

1982 • 590 citations

Identification of a human insulinoma cDNA encoding a novel mammalian protein structurally related to the yeast dibasic processing protease Kex2.

1990 • 579 citations

Enzymes Required for Yeast Prohormone Processing

1988 • 446 citations

Intraorganellar calcium and pH control proinsulin cleavage in the pancreatic β cell via two distinct site-specific endopeptidases

1988 • 403 citations

Intracellular Targeting and Structural Conservation of a Prohormone-Processing Endoprotease

1989 • 395 citations

Yeast prohormone processing enzyme (KEX2 gene product) is a Ca2+-dependent serine protease.

1989 • 386 citations

Conversion of proinsulin to insulin occurs coordinately with acidification of maturing secretory vesicles.

1986 • 331 citations

The processing of peptide precursors

1986 • 249 citations

Evolutionary conserved close linkage of the c-fes/fps proto-oncogene and genetic sequences encoding a receptor-like protein.

1986 • 207 citations

Studies on the Conversion of Proinsulin to Insulin

1971 • 206 citations

Cloning and sequence analysis of cDNA for bovine carboxypeptidase E

1986 • 196 citations

Conversion of proinsulin to insulin: involvement of a 31,500 molecular weight thiol protease.

1982 • 132 citations

Purification and characterization of a paired basic residue-specific prohormone-converting enzyme from bovine pituitary neural lobe secretory vesicles.

1986 • 85 citations

Enzymes that process somatostatin precursors. A novel endoprotease that cleaves before the arginine-lysine doublet is involved in somatostatin-28 convertase activity of rat brain cortex.

1987 • 84 citations

Subtilisin-like proteinases involved in the activation of proproteins of the eukaryotic secretory pathway

1990 • 74 citations

Proteolytic conversion of proinsulin into insulin. Identification of a Ca2+-dependent acidic endopeptidase in isolated insulin-secretory granules

1987 • 69 citations

Proinsulin endopeptidase substrate specificities defined by site-directed mutagenesis of proinsulin

1989 • 50 citations

Proocytocin neurophysin convertase from bovine neurohypophysis and corpus luteum secretory granules: complete purification, structure-function relationships, and competitive inhibitor

1989 • 38 citations

Direct evidence for two distinct prosomatostatin converting enzymes. Detection using a rapid, sensitive, and specific assay for propeptide converting enzymes.

1987 • 36 citations

The inhibition of proinsulin-processing endopeptidase activities by active-site-directed peptides

1989 • 33 citations

A putative processing enzyme for proenkephalin in bovine adrenal chromaffin granule membranes

1989 • 32 citations