Identification of new repeating motifs in titin

Basic local alignment search tool

1990 • 87,358 citations

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

1997 • 71,835 citations

Titins: Giant Proteins in Charge of Muscle Ultrastructure and Elasticity

1995 • 1,195 citations

The structure and function of proline-rich regions in proteins

1994 • 965 citations

A revised set of potentials for β‐turn formation in proteins

1994 • 912 citations

Passive tension in cardiac muscle: contribution of collagen, titin, microtubules, and intermediate filaments

1995 • 610 citations

The organization of titin filaments in the half-sarcomere revealed by monoclonal antibodies in immunoelectron microscopy: a map of ten nonrepetitive epitopes starting at the Z line extends close to the M line.

1988 • 608 citations

Titin: major myofibrillar components of striated muscle.

1979 • 523 citations

A physiological role for titin and nebulin in skeletal muscle

1986 • 449 citations

Series of Exon-Skipping Events in the Elastic Spring Region of Titin as the Structural Basis for Myofibrillar Elastic Diversity

2000 • 367 citations

Structural basis for activation of the titin kinase domain during myofibrillogenesis

1998 • 355 citations

Towards a molecular understanding of titin.

1992 • 338 citations

The premyofibril: Evidence for its role in myofibrillogenesis

1994 • 328 citations

Muscle assembly: a titanic achievement?

1999 • 323 citations

Regulation of skeletal muscle stiffness and elasticity by titin isoforms: a test of the segmental extension model of resting tension.

1991 • 314 citations

The NH2 Terminus of Titin Spans the Z-Disc: Its Interaction with a Novel 19-kD Ligand (T-cap) Is Required for Sarcomeric Integrity

1998 • 305 citations

A survey of left‐handed polyproline II helices

1999 • 250 citations

Nature of PEVK-titin elasticity in skeletal muscle

1998 • 246 citations

A regular pattern of two types of 100-residue motif in the sequence of titin

1990 • 244 citations

Does titin regulate the length of muscle thick filaments?

1989 • 240 citations

Connectin/titin, giant elastic protein of muscle

1997 • 240 citations

The Giant Protein Titin

1997 • 239 citations

Titin Extensibility In Situ: Entropic Elasticity of Permanently Folded and Permanently Unfolded Molecular Segments

1998 • 237 citations

Differential distribution of subsets of myofibrillar proteins in cardiac nonstriated and striated myofibrils.

1990 • 213 citations

Short elastin-like peptides exhibit the same temperature-induced structural transitions as elastin polymers: implications for protein engineering

1998 • 211 citations

Titin and nebulin: protein rulers in muscle?

1994 • 202 citations

The central Z-disk region of titin is assembled from a novel repeat in variable copy numbers

1996 • 168 citations

Connectin, an Elastic Protein from Myofibrils1

1976 • 159 citations

Studies on cardiac myofibrillogenesis with antibodies to titin, actin, tropomyosin, and myosin.

1988 • 156 citations

Extensible and Less-Extensible Domains of Connectin Filaments in Stretched Vertebrate Skeletal Muscle Sarcomeres as Detected by Immunofluorescence and Immunoelectron Microscopy Using Monoclonal Antibodies1

1988 • 151 citations

Passive tension and stiffness of vertebrate skeletal and insect flight muscles: the contribution of weak cross-bridges and elastic filaments

1993 • 135 citations

Immunocytochemical studies using a monoclonal antibody to bovine cardiac titin on intact and extracted myofibrils

1985 • 125 citations

Titin: a molecular control freak

1999 • 115 citations

Phosphorylation of KSP motifs in the C-terminal region of titin in differentiating myoblasts.

1993 • 111 citations

The structure of a high-Mr subunit of durum-wheat (Triticum durum) gluten

1987 • 109 citations

Alternative splicing generates variants in important functional domains of human slow skeletal troponin T.

1987 • 107 citations

Conformation of the RNA polymerase II C-terminal domain: circular dichroism of long and short fragments

2000 • 82 citations

Mechanochemical coupling in synthetic polypeptides by modulation of an inverse temperature transition.

1988 • 77 citations

PEVK Extension of Human Soleus Muscle Titin Revealed by Immunolabeling with the Anti-titin Antibody 9D10

1998 • 75 citations

Chicken cardiac myofibrillogenesis studied with antibodies specific for titin and the muscle and nonmuscle isoforms of actin and tropomyosin

1991 • 72 citations

Direct visualization of extensibility in isolated titin molecules

1997 • 66 citations

Characterization of a 5.4 kb cDNA fragment from the Z-line region of rabbit cardiac titin reveals phosphorylation sites for proline-directed kinases

1995 • 63 citations

Score Distributions for Simultaneous Matching to Multiple Motifs

1997 • 60 citations

Isolation of a cDNA for the rat heavy neurofilament polypeptide (NF‐H)

1986 • 47 citations

A Novel Domain Sequence of Connectin Localized at the I Band of Skeletal Muscle Sarcomeres: Homology to Neurofilament Subunits

1993 • 42 citations

The super-repeats of titin/connectin and their interactions: Glimpses at sarcomeric assembly

1996 • 26 citations

Sequence and Mechanical Implications of Titin’s PEVK Region

2000 • 18 citations

Single chicken cardiac myosin alkali light-chain gene generates two different mRNAs by alternative splicing of a complex exon

1988 • 15 citations

AN IMMUNOLOGICAL HOMOLOGY BETWEEN NEUROFILAMENT AND MUSCLE ELASTIC EILAMENT: A MONOCLONAL ANTIBODY CROSS-REACTS WITH NEUROFILAMENT SUBUNITS AND CONNECTIN

1988 • 13 citations

Evolution of the “titin epitope” in neurofilament proteins

1991 • 10 citations

The Immunological Homology between Two Filamentous Cross-Linker Phosphoproteins, Connectin and Cross-Bridge Region of Neurofilament-H, Is Not Affected by the Phosphorylation State1

1989 • 9 citations