DNA haplotype dependency of debrisoquine 4-hydroxylase (CYP2D6) expression among extensive metabolisers

P450 GENES: STRUCTURE, EVOLUTION, AND REGULATION

1987 • 1,559 citations

The P450 Superfamily: Update on New Sequences, Gene Mapping, and Recommended Nomenclature

1991 • 1,092 citations

Characterization of the common genetic defect in humans deficient in debrisoquine metabolism

1988 • 717 citations

A family and population study of the genetic polymorphism of debrisoquine oxidation in a white British population.

1980 • 544 citations

The human debrisoquine 4-hydroxylase (CYP2D) locus: sequence and identification of the polymorphic CYP2D6 gene, a related gene, and a pseudogene.

1989 • 407 citations

Metabolic oxidation phenotypes as markers for susceptibility to lung cancer

1984 • 386 citations

The genetic polymorphism of debrisoquine/sparteine metabolism — Clinical aspects

1990 • 367 citations

Hydroxylation polymorphisms of debrisoquine and mephenytoin in European populations

1990 • 363 citations

Identification of the primary gene defect at the cytochrome P450 CYP2D locus

1990 • 304 citations

Clinical significance of the sparteine/debrisoquine oxidation polymorphism

1989 • 292 citations

Deletion of the entire cytochrome P450 CYP2D6 gene as a cause of impaired drug metabolism in poor metabolizers of the debrisoquine/sparteine polymorphism.

1991 • 273 citations

Multiple mutations of the human cytochrome P450IID6 gene (CYP2D6) in poor metabolizers of debrisoquine. Study of the functional significance of individual mutations by expression of chimeric genes.

1990 • 263 citations

Debrisoquine/Sparteine Hydroxylation Genotype and Phenotype: Analysis of Common Mutations and Alleles ofCYP2D6in a European Population

1991 • 224 citations

Two mutant alleles of the human cytochrome P-450db1 gene (P450C2D1) associated with genetically deficient metabolism of debrisoquine and other drugs.

1988 • 199 citations

Recent Developments in Hepatic Drug Oxidation

1990 • 189 citations

Identification of a new variant CYP2D6 allele lacking the codon encoding Lys-281: possible association with the poor metabolizer phenotype

1991 • 147 citations

The human CYP2D locus associated with a common genetic defect in drug oxidation: a G1934----A base change in intron 3 of a mutant CYP2D6 allele results in an aberrant 3' splice recognition site.

1990 • 144 citations

Lung cancer risk, occupational exposure, and the debrisoquine metabolic phenotype

1990 • 140 citations

Molecular genetics of the debrisoquin-sparteine polymorphism

1991 • 132 citations

The genetic polymorphism of debrisoquine/sparteine metabolism—molecular mechanisms

1990 • 129 citations

Chromosomal assignment of human cytochrome P-450 (debrisoquine/sparteine type) to chromosome 22.

1987 • 112 citations

Genetic and metabolic criteria for the assignment of debrisoquine 4-hydroxylation (cytochrome P4502D6) phenotypes

1991 • 91 citations

Phenotyping polymorphic drug metabolism in the French Caucasian population

1988 • 75 citations

Genetically determined oxidation capacity and the disposition of debrisoquine.

1983 • 60 citations

Debrisoquine oxidation phenotype and susceptibility to lung cancer.

1990 • 51 citations

Phenotypic differences in dextromethorphan metabolism.

1989 • 32 citations

Direct determination of dextromethorphan and its three metabolites in urine by high-performance liquid chromatography using a precolumn switching system for sample clean-up

1987 • 17 citations

Xbal 16- plus 9-kilobase DNA restriction fragments identify a mutant allele for debrisoquin hydroxylase: report of a family study.

1990 • 14 citations

Molecular heterogeneity of the XbaI defined 44kb allele of the CYP2D locus within the Caucasian population.

1993 • 7 citations

Ncol RFLP in the pseudogene (CYP2D8P) of the human debrisoquine 4-hydroxylase locus

1991 • 3 citations

Deleted Work

1955 • 0 citations