Imipramine demethylation in vivo: Impact of CYP1A2, CYP2C19, and CYP3A4*

Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines.

1989 • 643 citations

Noninvasive tests of CYP3A enzymes

1994 • 414 citations

Fluvoxamine is a potent inhibitor of cytochrome P4501A2

1993 • 370 citations

The increase in urinary excretion of 6 beta‐hydroxycortisol as a marker of human hepatic cytochrome P450IIIA induction.

1989 • 334 citations

Oxidation of quinidine by human liver cytochrome P-450.

1986 • 296 citations

Isolation and Characterization of Human Liver Cytochrome P450 2C19: Correlation between 2C19 and S-Mephenytoin 4′-Hydroxylation

1993 • 286 citations

The use of caffeine for enzyme assays: A critical appraisal

1993 • 282 citations

A form of cytochrome P450 in man, orthologous to form d in the rat, catalyses the O‐deethylation of phenacetin and is inducible by cigarette smoking.

1988 • 236 citations

A urinary metabolite ratio that reflects systemic caffeine clearance

1987 • 194 citations

Simple and reliable CYP1A2 phenotyping by the paraxanthine/caffeine ratio in plasma and in saliva

1994 • 179 citations

Major pathway of imipramine metabolism is catalyzed by cytochromes P-450 1A2 and P-450 3A4 in human liver.

1993 • 168 citations

Inhibitors of imipramine metabolism by human liver microsomes.

1992 • 165 citations

The mephenytoin oxidation polymorphism is partially responsible for the N-demethylation of imipramine

1991 • 139 citations

Comparison of urinary 6-β-cortisol and the erythromycin breath test as measures of hepatic P450IIIA (CYP3A) activity

1992 • 138 citations

Absence of correlations among three putative in vivo probes of human cytochrome P4503A activity in young healthy men

1993 • 137 citations

Evidence for the involvement of several cytochromes P-450 in the first steps of caffeine metabolism by human liver microsomes.

1991 • 123 citations

S-mephenytoin hydroxylation phenotypes in a Swedish population determined after coadministration with debrisoquin

1989 • 116 citations

Role of P450IID6, the target of the sparteine-debrisoquin oxidation polymorphism, in the metabolism of imipramine

1991 • 114 citations

A fluvoxamine-caffeine interaction study

1996 • 104 citations

Imipramine demethylation and hydroxylation: Impact of the sparteine oxidation phenotype

1986 • 101 citations

The debrisoquine hydroxylation test predicts steady‐state plasma levels of desipramine.

1983 • 93 citations

In vitro proguanil activation to cycloguanil by human liver microsomes is mediated by CYP3A isoforms as well as by S‐mephenytoin hydroxylase.

1994 • 84 citations

Determination of Urinary Metabolites of Caffeine for the Assessment of Cytochrome P4501A2, Xanthine Oxidase, and N-Acetyltransferase Activity in Humans

1996 • 81 citations

Steady-state levels of imipramine and its metabolites: Significance of dose-dependent kinetics

1986 • 77 citations

Interaction Between Fluvoxamine and Imipramine/Desipramine in Four Patients

1992 • 75 citations

Sparteine Oxidation Polymorphism in Denmark

1985 • 68 citations

Phenytoin Causes a Rapid Increase in 6β‐Hydroxycortisol Urinary Excretion in Humans—A Putative Measure of CYP3A Induction

1995 • 63 citations

Simultaneous determination of urinary free cortisol and 6β-hydroxycortisol by high-performance liquid chromatography to measure human CYP3A activity

1994 • 58 citations

Chloroguanide metabolism in relation to the efficacy in malaria prophylaxis and the S-mephenytoin oxidation in Tanzanians*

1996 • 55 citations

Imipramine metabolism in relation to the sparteine and mephenytoin oxidation polymorphisms—a population study.

1995 • 54 citations

The role of S‐mephenytoin 4'‐hydroxylase in imipramine metabolism by human liver microsomes: a two‐enzyme kinetic analysis of N‐ demethylation and 2‐hydroxylation.

1994 • 50 citations

Proguanil metabolism is determined by the mephenytoin oxidation polymorphism in Vietnamese living in Denmark.

1993 • 41 citations

Imipramine metabolism in man

1967 • 38 citations

Determination of quinidine, dihydroquinidine, (3S)-3-hydroxyquinidine and quinidine N-oxide in plasma and urine by high-performance liquid chromatography

1994 • 34 citations

Mephenytoin and sparteine oxidation: genetic polymorphisms in Denmark.

1989 • 33 citations

Determination of theophylline and its metabolites in human urine and plasma by high-performance liquid chromatography

1996 • 30 citations

High-performance liquid chromatography of imipramine and six metabolites in human plasma and urine

1993 • 28 citations

The N-demethylation of imipramine correlates with the oxidation of S-mephenytoin (S/R-ratio). A population study.

1993 • 25 citations

Imipramine: A model substance in pharmacokinetic research

1988 • 9 citations