Alterations in Leukocyte β-Receptor Affinity with Aging

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONS

1949 • 19,979 citations

Isolation of mononuclear cells and granulocytes from human blood.

1968 • 9,672 citations

A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor.

1980 • 1,579 citations

A simplified radiometric assay for plasma norepinephrine and epinephrine

1973 • 648 citations

Reduced β‐adrenoceptor sensitivity in the elderly

1979 • 621 citations

Validation and statistical analysis of a computer modeling method for quantitative analysis of radioligand binding data for mixtures of pharmacological receptor subtypes.

1982 • 573 citations

A quantitative analysis of beta-adrenergic receptor interactions: resolution of high and low affinity states of the receptor by computer modeling of ligand binding data.

1980 • 545 citations

Identification of beta-adrenergic receptors in human lymphocytes by (-) (3H) alprenolol binding.

1976 • 398 citations

Diminished inotropic response of aged myocardium to catecholamines.

1975 • 336 citations

Decreased Lymphocyte Beta-Adrenergic-Receptor Density in Patients with Heart Failure and Tolerance to the Beta-Adrenergic Agonist Pirbuterol

1981 • 331 citations

Decreased Beta-adrenoreceptor responsiveness as related to age, blood pressure, and plasma catecholamines in patients with essential hypertension.

1980 • 325 citations

Activation and attenuation of adenylate cyclase. The role of GTP-binding proteins as macromolecular messengers in receptor–cyclase coupling

1981 • 322 citations

Reduced β-adrenergic receptor concentrations in ageing man

1977 • 258 citations

Regulation of Human Leukocyte Beta Receptors by Endogenous Catecholamines

1981 • 194 citations

Changes in the density of beta adrenergic receptors in rat lymphocytes, heart and lung after chronic treatment with propranolol.

1982 • 158 citations

Human Lymphocyte Beta-adrenergic Receptors Are Unaltered With Age

1981 • 136 citations

Beta-Receptor Activity in Aorta

1970 • 133 citations

Age and beta adrenoceptor–mediated function

1980 • 120 citations

High affinity beta-2-adrenergic receptors in mononuclear leucocytes: Similar density in young and old normal subjects

1981 • 107 citations

Dynamic regulation of leukocyte beta adrenergic receptor-agonist interactions by physiological changes in circulating catecholamines.

1983 • 107 citations

CATALYTIC UNIT OF ADENYLATE CYCLASE: REDUCED ACTIVITY IN AGED-HUMAN LYMPHOCYTES

1982 • 94 citations

Age-Related Elevation of Plasma Catecholamine Concentration and Reduced Responsiveness of Lymphocyte Adenylate Cyclase*

1981 • 88 citations

Decreased beta adrenergic receptor density on human lymphocytes after chronic treatment with agonists.

1983 • 81 citations

Human Lymphocyte β-Adrenoceptor Density in Relation to Age and Hypertension

1982 • 60 citations

Human Lymphocytes as a Model for Beta-Adrenergic Receptors in Clinical Investigation

1983 • 43 citations

Endogenous and Exogenous Regulation of Human α- and β-Adrenergic Receptors

1983 • 38 citations

Changes in Hormone Binding and Responsiveness in Target Cells and Tissues During Aging

1975 • 26 citations