Cyclin A‐mediated inhibition of intra‐Golgi transport requires p34^cdc2

Universal control mechanism regulating onset of M-phase

1990 • 2,882 citations

Staurosporine, a potent inhibitor of phospholipidCa++dependent protein kinase

1986 • 2,445 citations

Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Specificity and kinetics

1988 • 1,699 citations

Cyanobacterial microcystin‐LR is a potent and specific inhibitor of protein phosphatases 1 and 2A from both mammals and higher plants

1990 • 1,627 citations

Cyclin: A protein specified by maternal mRNA in sea urchin eggs that is destroyed at each cleavage division

1983 • 1,506 citations

Cyclin A is required at two points in the human cell cycle.

1992 • 1,380 citations

ANIMAL CELL CYCLES AND THEIR CONTROL

1992 • 1,239 citations

Human cyclins A and B1 are differentially located in the cell and undergo cell cycle-dependent nuclear transport.

1991 • 858 citations

In vitro disassembly of the nuclear lamina and M phase-specific phosphorylation of lamins by cdc2 kinase

1990 • 783 citations

Purification of maturation-promoting factor, an intracellular regulator of early mitotic events.

1988 • 640 citations

Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15.

1992 • 638 citations

Regulatory phosphorylation of the p34cdc2 protein kinase in vertebrates.

1991 • 502 citations

Regulation of the cdc25 protein during the cell cycle in Xenopus extracts

1992 • 430 citations

The cdc2-related protein p40MO15 is the catalytic subunit of a protein kinase that can activate p33cdk2 and p34cdc2.

1993 • 377 citations

The A- and B-type cyclin associated cdc2 kinases in Xenopus turn on and off at different times in the cell cycle.

1990 • 377 citations

Human cyclin-dependent kinase 2 is activated during the S and G2 phases of the cell cycle and associates with cyclin A.

1992 • 331 citations

Characterization of protein transport between successive compartments of the Golgi apparatus: Asymmetric properties of donor and acceptor activities in a cell-free system

1985 • 301 citations

The interaction of antibody with the major surface glycoprotein of vesicular stomatitis virus I. Analysis of neutralizing epitopes with monoclonal antibodies

1982 • 284 citations

Okadaic acid, a potent inhibitor of type 1 and type 2A protein phosphatases, activates cdc2/H1 kinase and transiently induces a premature mitosis-like state in BHK21 cells.

1990 • 280 citations

MEMBRANE PARTITIONING DURING CELL DIVISION

1993 • 273 citations

A new human p34 protein kinase, CDK2, identified by complementation of a cdc28 mutation in Saccharomyces cerevisiae, is a homolog of Xenopus Eg1.

1991 • 265 citations

Cdc2 H1 kinase is negatively regulated by a type 2A phosphatase in the Xenopus early embryonic cell cycle: evidence from the effects of okadaic acid.

1990 • 244 citations

The FT210 cell line is a mouse G2 phase mutant with a temperature-sensitive CDC2 gene product

1990 • 222 citations

Sequential intermediates in the pathway of intercompartmental transport in a cell-free system

1984 • 211 citations

Binding of an N-ethylmaleimide-sensitive fusion protein to Golgi membranes requires both a soluble protein(s) and an integral membrane receptor.

1989 • 184 citations

Okadaic acid, a specific protein phosphatase inhibitor, induces maturation and MPF formation in Xenopus laevis oocytes

1989 • 179 citations

Reversible phosphorylation--dephosphorylation determines the localization of rab4 during the cell cycle.

1992 • 149 citations

Surface functions during mitosis. II. Quantitation of pinocytosis and kinetic characterization of the mitotic cycle with a new fluorescence technique.

1980 • 136 citations

Recycling of transferrin receptors in A431 cells is inhibited during mitosis.

1984 • 128 citations

Evidence for the regulation of exocytic transport by protein phosphorylation.

1992 • 126 citations

A post-ribosomal supernatant from activated Xenopus eggs that displays post-translationally regulated oscillation of its cdc2+ mitotic kinase activity.

1989 • 126 citations

The substrates of the cdc2 kinase.

1991 • 115 citations

Okadaic acid induces golgi apparatus fragmentation and arrest of intracellular transport

1991 • 113 citations

Newly synthesized G protein of vesicular stomatitis virus is not transported to the Golgi complex in mitotic cells.

1985 • 107 citations

Chemically induced premature mitosis: differential response in rodent and human cells and the relationship to cyclin B synthesis and p34cdc2/cyclin B complex formation.

1991 • 106 citations

Cyclin A- and cyclin B-dependent protein kinases are regulated by different mechanisms in Xenopus egg extracts.

1992 • 91 citations

Cell-free fusion of endocytic vesicles is regulated by phosphorylation.

1992 • 87 citations

Cyclin A potentiates maturation-promoting factor activation in the early Xenopus embryo via inhibition of the tyrosine kinase that phosphorylates cdc2.

1992 • 75 citations

Sphingolipid transport in mitotic HeLa cells.

1992 • 62 citations

p34cdc2 acts as a lamin kinase in fission yeast.

1991 • 61 citations

Inhibition of intra-Golgi transport in vitro by mitotic kinase.

1993 • 49 citations

Isolation and analysis of a mammalian temperature-sensitive mutant defective in G2 functions

1986 • 47 citations

Inhibition of membrane fusion in vitro via cyclin B but not cyclin A.

1992 • 41 citations

Characterization of the in vitro reconstituted cyclin A or B1-dependent cdk2 and cdc2 kinase activities.

1993 • 38 citations

In vitro fusion of endocytic vesicles is inhibited by cyclin A-cdc2 kinase.

1993 • 31 citations