A novel STAT3 inhibitor, S3I-201, attenuates renal interstitial fibroblast activation and interstitial fibrosis in obstructive nephropathy

Cellular and molecular mechanisms of fibrosis

2007 • 4,007 citations

TGF‐β signaling and the fibrotic response

2004 • 2,195 citations

Maximal activation of transcription by statl and stat3 requires both tyrosine and serine phosphorylation

1995 • 1,960 citations

A Road Map for Those Who Don't Know JAK-STAT

2002 • 1,292 citations

Renal fibrosis: New insights into the pathogenesis and therapeutics

2006 • 1,029 citations

Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor

1996 • 915 citations

Ureteral obstruction as a model of renal interstitial fibrosis and obstructive nephropathy

2009 • 901 citations

STAT3 is a Critical Regulator of Astrogliosis and Scar Formation after Spinal Cord Injury

2008 • 859 citations

Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity

2007 • 727 citations

TGF-ß Signaling in Renal Disease

2002 • 715 citations

STAT proteins: novel molecular targets for cancer drug discovery

2000 • 634 citations

RANTES and Monocyte Chemoattractant Protein–1 (MCP-1) Play an Important Role in the Inflammatory Phase of Crescentic Nephritis, but Only MCP-1 Is Involved in Crescent Formation and Interstitial Fibrosis

1997 • 498 citations

The role of epithelial-to-mesenchymal transition in renal fibrosis

2004 • 491 citations

STAT proteins and transcriptional responses to extracellular signals

2000 • 484 citations

Monocyte chemoattractant protein-1 promotes the development of diabetic renal injury in streptozotocin-treated mice

2005 • 421 citations

Interleukin-8 and the chemokine family

1995 • 400 citations

Pathobiology of transforming growth factor β in cancer, fibrosis and immunologic disease, and therapeutic considerations

2007 • 392 citations

Role of matrix metalloproteinases in renal pathophysiologies

2006 • 358 citations

Enhanced Expression of Janus Kinase–Signal Transducer and Activator of Transcription Pathway Members in Human Diabetic Nephropathy

2008 • 289 citations

Fibroblast activation and myofibroblast generation in obstructive nephropathy

2009 • 254 citations

Loss of SOCS3 in the liver promotes fibrosis by enhancing STAT3-mediated TGF-β1 production

2006 • 236 citations

Role of Wnt/β‐catenin signaling pathway in epithelial‐mesenchymal transition of human prostate cancer induced by hypoxia‐inducible factor‐1α

2007 • 205 citations

Mechanisms of Disease: fibroblasts—a new look at an old problem

2006 • 199 citations

Inhibition of histone deacetylase activity attenuates renal fibroblast activation and interstitial fibrosis in obstructive nephropathy

2009 • 199 citations

Obstructive nephropathy: towards biomarker discovery and gene therapy

2006 • 175 citations

JAK3, STAT, and MAPK Signaling Pathways as Novel Molecular Targets for the Tyrphostin AG-490 Regulation of IL-2-Mediated T Cell Response

1999 • 164 citations

Assessment and Prognostic Significance of Mitotic Index Using the Mitosis Marker Phospho-histone H3 in Low and Intermediate-grade Infiltrating Astrocytomas

2006 • 133 citations

Proinflammatory gene expression and macrophage recruitment in the rat remnant kidney

2000 • 116 citations

Loss of STAT5 causes liver fibrosis and cancer development through increased TGF-β and STAT3 activation

2009 • 111 citations

Activation of Stat3 preassembled with platelet-derived growth factor β receptors requires Src kinase activity

2000 • 111 citations

Analysis of Stat3 (signal transducer and activator of transcription 3) dimerization by fluorescence resonance energy transfer in living cells

2004 • 106 citations

Transcriptional Control Mechanism of Fibrinogen Gene Expression

2001 • 105 citations

Interleukin-1β induces human proximal tubule cell injury, α-smooth muscle actin expression and fibronectin production1

2002 • 105 citations

Signal transducer and activator of transcription 3 involvement in the development of renal interstitial fibrosis after unilateral ureteral obstruction

2007 • 81 citations

Inflammatory mediators and growth factors in obstructive renal injury

2004 • 80 citations

Cytokine Profiling and Stat3 Phosphorylation in Epithelial–Mesenchymal Interactions between Keloid Keratinocytes and Fibroblasts

2008 • 77 citations

STAT3: An Important Regulator of Multiple Cytokine Functions

2008 • 75 citations

Cross‐talk between IL‐6 and TGF‐β signaling in hepatoma cells

2001 • 66 citations

Cadherin–catenin complex and transcription factor Snail-1 in spindle cell carcinoma of the head and neck

2008 • 65 citations

Prevention of progressive fibrosis in chronic renal diseases: antifibrotic agents.

2004 • 62 citations

Activation of signal transducer and activator of transcription 3 correlates with cell proliferation and renal injury in human glomerulonephritis

2008 • 58 citations

PDGF-driven proliferation, migration, and IL8 chemokine secretion in human corneal fibroblasts involve JAK2-STAT3 signaling pathway.

2008 • 57 citations

Susceptibility of Signal Transducer and Activator of Transcription-1-Deficient Mice to Pulmonary Fibrogenesis

2005 • 55 citations

Cytokines in Epithelial-Mesenchymal Transition: A New Insight Into Obstructive Nephropathy

2008 • 49 citations

Glycogen Synthase Kinase 3β: A Novel Marker and Modulator of Inflammatory Injury in Chronic Renal Allograft Disease

2008 • 38 citations

Basal c-Jun N-terminal kinases promote mitotic progression through histone H3 phosphorylation

2008 • 22 citations

Interacting Roles of Myofibroblasts, Apoptosis and Fibrogenic Growth Factors in the Pathogenesis of Renal Tubulo-interstitial Fibrosis

2002 • 22 citations

Possible participation of a JAK2 signaling pathway in recombinant rat interleukin-5-induced prolongation of rat eosinophil survival

2001 • 16 citations