Phorbol diesters inhibit enzymatic hydrolysis of diacylglycerols in vitro.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1959 • 47,127 citations

Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

1982 • 4,786 citations

Continuous growth and differentiation of human myeloid leukaemic cells in suspension culture

1977 • 2,134 citations

Phorbol diester receptor copurifies with protein kinase C.

1983 • 1,185 citations

Establishment and characterization of a cloned line of C3H mouse embryo cells sensitive to postconfluence inhibition of division.

1973 • 1,126 citations

Human promyelocytic leukemia cells in culture differentiate into macrophage-like cells when treated with a phorbol diester.

1979 • 1,019 citations

Protein kinase C as a possible receptor protein of tumor-promoting phorbol esters.

1983 • 890 citations

Quantitative and qualitative studies of chemical transformation of cloned C3H mouse embryo cells sensitive to postconfluence inhibition of cell division.

1973 • 843 citations

Unsaturated diacylglycerol as a possible messenger for the activation of calcium-activated, phospholipid-dependent protein kinase system

1979 • 727 citations

Induction of terminal differentiation in human promyelocytic leukemia cells by tumor-promoting agents.

1979 • 513 citations

Phosphatidyldmositol hydrolysis: A multifunctional transducing mechanism

1981 • 341 citations

Exogenous sn-1,2-diacylglycerols containing saturated fatty acids function as bioregulators of protein kinase C in human platelets.

1985 • 308 citations

Diacylglycerols mimic phorbol diester induction of leukemic cell differentiation.

1985 • 234 citations

Dissociation of protein kinase C activation from phorbol ester-induced maturation of HL-60 leukemia cells.

1985 • 218 citations

Relative activities of rat and dog platelet phospholipase A2 and diglyceride lipase. Selective inhibition of diglyceride lipase by RHC 80267.

1982 • 199 citations

Phosphatidylinositol turnover in platelet activation; Calcium mobilization and protein phosphorylation

1982 • 193 citations

Specificity of the Fatty Acyl Moieties of Diacylglycerol for the Activation of Calcium-Activated, Phospholipid-Dependent Protein Kinase1

1982 • 182 citations

Replacement of serum by insulin and transferrin supports growth and differentiation of the human promyelocytic cell line, HL-60

1980 • 170 citations

Diacylglycerol modulates binding and phosphorylation of the epidermal growth factor receptor.

1984 • 168 citations

Tumor promoters: Effects on proliferation and differentiation of cells in culture

1978 • 145 citations

Inositol lipid metabolism in dividing and differentiating cells

1982 • 119 citations

Structural analyses of rat liver phosphoglycerides

1969 • 119 citations

Role of protein kinase C in diacylglycerol-mediated induction of ornithine decarboxylase and reduction of epidermal growth factor binding.

1985 • 94 citations

Structural and chemical specificity of diradylglycerols for protein kinase C activation

1984 • 92 citations

Modulation of protein kinase C activity and [3H]phorbol 12,13-dibutyrate binding by various tumor promoters in mouse brain cytosol.

1985 • 88 citations

1-O-hexadecyl-2-acetyl-sn-glycerol stimulates differentiation of HL-60 human promyelocytic leukemia cells to macrophage-like cells

1984 • 65 citations

Alterations in lipid metabolism induced by 12-O-tetradecanoylphorbol-13-acetate in differentiating human myeloid leukemia cells.

1980 • 52 citations

Metabolism of tritium-labeled 12-O-tetradecanoylphorbol-13-acetate by cells in culture.

1978 • 41 citations

Induction of ornithine decarboxylase activity by 1-oleoyl-2-acetyl-glycerol in isolated mouse epidermal cells

1985 • 37 citations

Metabolic conversion of 12-O-tetradecanoylphorbol-13-acetate in adult and newborn mouse skin and mouse liver microsomes.

1978 • 30 citations

Isolation and characterization of an ester hydrolase active on phorbol diesters from murine liver.

1981 • 26 citations

Serum lipase active in the hydrolysis of the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate

1983 • 14 citations

Lipases of Rat Brain Microsomes

1978 • 14 citations

Tumor promoting phorbol diesters: Substrates for diacylglycerol lipase

1984 • 13 citations

Isolation and characterization of a murine serum esterase which hydrolyzes a tumor promoter, 12-O-tetradecanoyl phorbol 13-acetate.

1984 • 10 citations

Deacylation of 12-O-[3H]tetradecanoylphorbol-13-acetate and [3H]phorbol-12,13-didecanoate in hamster skin and hamster cells in culture.

1982 • 10 citations

Ether lipid studies in mouse C3H/10T1/2 cells and a 3-methylcholanthrene-transformed clone

1981 • 9 citations

Modification of lipid acyl groups by serum deprivation does not affect phorbol ester-induced differentiation of human leukemia cells

1982 • 8 citations

Hydrolysis of novel diacylglycerol and phorbol diesters by serum lipase

1985 • 7 citations