Synchronous and metachronous lung carcinomas: Molecular evidence for multicentricity

p53 Mutations in Human Cancers

1991 • 8,133 citations

A new method for sequencing DNA.

1977 • 7,941 citations

The p53 tumour suppressor gene

1991 • 3,871 citations

Mutations in the p53 gene occur in diverse human tumour types

1989 • 2,765 citations

Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes

1988 • 2,121 citations

Multiple primary malignant tumors. A survey of the literature and a statistical study

1932 • 2,001 citations

Amplification of a gene encoding a p53-associated protein in human sarcomas

1992 • 1,959 citations

Prevalence of ras gene mutations in human colorectal cancers

1987 • 1,866 citations

Multiple primary lung cancers

1975 • 1,243 citations

Detection of high incidence of K-ras oncogenes during human colon tumorigenesis

1987 • 1,074 citations

K-rasOncogene Activation as a Prognostic Marker in Adenocarcinoma of the Lung

1990 • 811 citations

KRAS codon 12 mutations occur very frequently in pancreatic adenocarcinomas

1988 • 620 citations

Mutations in the p53 gene are frequent in primary, resected non-small cell lung cancer. Lung Cancer Study Group.

1990 • 515 citations

Adjuvant treatment of stage I lung cancer with high-dose vitamin A.

1993 • 353 citations

p53 mutations, ras mutations, and p53-heat shock 70 protein complexes in human lung carcinoma cell lines.

1991 • 349 citations

p53 Protein accumulates frequently in early bronchial neoplasia

1994 • 211 citations

Expression of mutated p53 occurs in tumor-distant epithelia of head and neck cancer patients: a possible molecular basis for the development of multiple tumors.

1993 • 200 citations

Second primary lung cancer

1995 • 194 citations

Mutations in the p53 gene are frequent in primary, resected non-small cell lung cancer

1991 • 173 citations

Genetic evidence for an independent origin of multiple preneoplastic and neoplastic lung lesions

1995 • 160 citations

Interaction of the human papillomavirus type 16 E6 oncoprotein with wild-type and mutant human p53 proteins

1992 • 131 citations

Detection of c-Ki-ras gene mutation in paraffin sections of adenocarcinoma and atypical bronchioloalveolar cell hyperplasia of human lung

1994 • 77 citations

Detection of K-ras gene mutations in non-neoplastic lung tissue and lung cancers

1996 • 72 citations

Multiple Primary Cancers in 5,456 Autopsy Cases in the National Cancer Center of Japan<xref ref-type="fn" rid="FN2">2</xref>

1984 • 68 citations

Human non‐small cell lung cancer: P53 protein accumulation is an early event and persists during metastatic progression

1994 • 55 citations

Synchronous non-small cell lung cancers

1996 • 50 citations

p53 Expression, mutation, and allelic deletion in ovarian cancer

1994 • 48 citations

Application of the p53 Gene Mutation Pattern for Differential Diagnosis of Primary Versus Metastatic Lung Carcinomas

1993 • 42 citations

Application of the p53 Gene Mutation Pattern for Differential Diagnosis of Primary Versus Metastatic Lung Carcinomas

1993 • 42 citations

Nuclear p53 accumulation by small‐sized adenocarcinomas of the lung

1996 • 32 citations

A Universal Method for the Mutational Analysis of K-ras and p53 Gene in Non-small-cell Lung Cancer Using Formalin-Fixed Paraffin-Embedded Tissue

1995 • 27 citations

Alteration of the p53 gene of lung carcinomas with sarcomatous transformation (spindle cell carcinoma): Analysis of four cases

1996 • 18 citations