Application of Artificial Pigments to Structure Determination and Study of Photoinduced Transformations of Retinal Proteins

The probable arrangement of the helices in G protein-coupled receptors.

1993 • 977 citations

Projection structure of rhodopsin

1993 • 758 citations

Photochemistry in Organized and Constrained Media

1991 • 740 citations

Glutamic acid-113 serves as the retinylidene Schiff base counterion in bovine rhodopsin.

1989 • 663 citations

Vibrationally Coherent Photochemistry in the Femtosecond Primary Event of Vision

1994 • 624 citations

Bicycle-pedal model for the first step in the vision process

1976 • 527 citations

Constitutively active mutants of rhodopsin

1992 • 513 citations

Light Antennas in phototactic algae

1980 • 390 citations

A rhodopsin is the functional photoreceptor for phototaxis in the unicellular eukaryote Chlamydomonas

1984 • 372 citations

An external point-charge model for bacteriorhodopsin to account for its purple color

1980 • 327 citations

An external point-charge model for wavelength regulation in visual pigments

1979 • 323 citations

Determination of Membrane Protein Structure by Rotational Resonance NMR: Bacteriorhodopsin

1991 • 244 citations

THE MECHANISM OF BLEACHING RHODOPSIN

1958 • 241 citations

The first step in vision occurs in femtoseconds: complete blue and red spectral studies.

1993 • 185 citations

The sudden polarization effect and its possible role in vision

1979 • 179 citations

Rod Outer Segment Retinol Dehydrogenase: Substrate Specificity and Role in Phototransduction

1994 • 171 citations

Photoreceptor Degeneration in Vitamin A Deprivation and Retinitis Pigmentosa: the Equivalent Light Hypothesis

1993 • 150 citations

Nonbleachable rhodopsins retaining the full natural chromophore

1980 • 139 citations

Studies on the Retinal-Protein Interaction in Bacteriorhodopsin

1977 • 137 citations

Conversion of a photon to an electrical signal by sudden polarisation in the N-retinylidene visual chromophore

1975 • 131 citations

Removal of the 9-methyl group of retinal inhibits signal transduction in the visual process. A fourier transform infrared and biochemical investigation

1989 • 131 citations

Chromophore/protein interaction in bacterial sensory rhodopsin and bacteriorhodopsin

1986 • 130 citations

Two-photon spectroscopy of locked-11-cis-rhodopsin: evidence for a protonated Schiff base in a neutral protein binding site.

1985 • 125 citations

Hydroretinals and hydrorhodopsins

1979 • 123 citations

The spectral properties of some visual pigment analogs

1973 • 115 citations

All-trans retinal constitutes the functional chromophore in Chlamydomonas rhodopsin

1991 • 114 citations

Orientation of retinal in bovine rhodopsin determined by cross-linking using a photoactivatable analog of 11-cis-retinal.

1990 • 112 citations

Color regulation in the archaebacterial phototaxis receptor phoborhodopsin (sensory rhodopsin II)

1990 • 111 citations

Controlling the pKa of the bacteriorhodopsin Schiff base by use of artificial retinal analogues.

1986 • 108 citations

Existence of a β-ionone ring-binding site in the rhodopsin molecule

1975 • 107 citations

INVERTEBRATE VISUAL PIGMENTS

1995 • 104 citations

Is the Fly Visual Pigment a Rhodopsin?

1983 • 97 citations

Noncovalent occupancy of the retinal-binding pocket of opsin diminishes bleaching adaptation of retinal cones

1993 • 97 citations

Femtosecond dynamics of cis-trans isomerization in a visual pigment analog: isorhodopsin

1993 • 96 citations

Light-stable rhodopsin. I. A rhodopsin analog reconstituted with a nonisomerizable 11-cis retinal derivative.

1992 • 91 citations

Rotational resonance NMR study of the active site structure in bacteriorhodopsin: conformation of the Schiff base linkage

1992 • 91 citations

Orientation of the protonated retinal Schiff base group in bacteriorhodopsin from absorption linear dichroism

1989 • 89 citations

Studies on structure and function of rhodopsin by use of cyclopentatrienylidene 11-cis-locked-rhodopsin

1984 • 89 citations

A mechanism for controlling the pKa of the retinal protonated Schiff base in retinal proteins. A study with model compounds

1993 • 88 citations

pKa of the protonated Schiff base of bovine rhodopsin. A study with artificial pigments

1993 • 87 citations

The Behaviour of Visual Pigments at Low Temperatures

1972 • 86 citations

Isorhodopsin II: artificial photosensitive pigment formed from 9,13-dicis retinal.

1975 • 85 citations

Retinal analog restoration of photophobic responses in a blind Chlamydomonas reinhardtii mutant. Evidence for an archaebacterial like chromophore in a eukaryotic rhodopsin

1991 • 77 citations

Identification of signaling states of a sensory receptor by modulation of lifetimes of stimulus-induced conformations: the case of sensory rhodopsin II

1991 • 76 citations

Theoretical studies of the visual chromophore

1975 • 75 citations

Removal of methyl groups from retinal controls the activity of bacteriorhodopsin

1983 • 74 citations

Bleached pigment activates transduction in salamander cones.

1995 • 71 citations

Regeneration of bovine and octopus opsins in situ with natural and artificial retinals

1989 • 71 citations

Properties of several sterically modified retinal analogs and their photosensitive pigments

1975 • 67 citations

Relief of opsin desensitization and prolonged excitation of rod photoreceptors by 9-desmethylretinal.

1994 • 67 citations

10,20‐Methanorhodopsins: (7E, 9E, 13E)‐10, 20‐methanorhodopsin and (7E, 9Z, 13Z)‐10, 20‐methanorhodopsin

1990 • 67 citations

Mechanism of isomerization of rhodopsin studied by use of 11-cis-locked rhodopsin analogs excited with a picosecond laser pulse

1989 • 65 citations

Light activation of bovine rod phosphodiesterase by non‐physiological visual pigments

1980 • 65 citations

Evidence for the prolonged photoactivated lifetime of an analogue visual pigment containing 11-cis9-desmethylretinal

1994 • 64 citations

Evidence for the necessity of double bond (13-ene) isomerization in the proton pumping of bacteriorhodopsin

1983 • 64 citations

Photoisomerization of retinal at 13-ene is important for phototaxis of Chlamydomonas reinhardtii: Simultaneous measurements of phototactic and photophobic responses

1991 • 64 citations

Interactions of the .BETA.-ionone Ring with the Protein in the Visual Pigment Rhodopsin Control the Activation Mechanism. An FTIR and Fluorescence Study on Artificial Vertebrate Rhodopsins

1994 • 64 citations

Azulenic retinoids and the corresponding bacteriorhodopsin analogs. Unusually red-shifted pigments

1990 • 62 citations

On the three visual pigments in the retina of the firefly squid, Watasenia scintillans

1990 • 62 citations

Unbleachable rhodopsin with an 11-cis-locked eight-membered ring retinal: The visual transduction process

1994 • 61 citations

Structure determination of the cyclohexene ring of retinal in bacteriorhodopsin by solid-state deuterium NMR

1992 • 61 citations

Properties of 14-methylretinal, 13-desmethyl-14-methylretinal, and visual pigments formed therefrom

1974 • 61 citations

Rhodopsin analogues from highly hindered 7-cis isomers of retinal

1976 • 60 citations

Interaction of tryptophan-182 with the retinal 9-methyl group in the L intermediate of bacteriorhodopsin

1995 • 58 citations

A new photolysis intermediate in artificial and native visual pigments

1991 • 58 citations

Activation of Chlamydomonas rhodopsin in vivo does not require isomerization of retinal

1989 • 56 citations

Photoisomerization mechanism of the rhodopsin chromophore: picosecond photolysis of pigment containing 11-cis-locked eight-membered ring retinal.

1993 • 56 citations

All E‐10,20‐methanoretinoylopsin, light‐stable rhodopsin. Synthesis and spectroscopy of all E‐10,20‐methano‐ and all‐E‐retinoyl fluoride and their reaction with bovine opsin

1989 • 55 citations

Comparative study on the chromophore binding sites of rod and red-sensitive cone visual pigments by use of synthetic retinal isomers and analogs

1990 • 53 citations

All-trans/13-cis isomerization of retinal is required for phototaxis signaling by sensory rhodopsins in Halobacterium halobium

1990 • 51 citations

4-Hydroxyretinal, a new visual pigment chromophore found in the bioluminescent squid, Watasenia scintillans

1988 • 51 citations

FTIR evidence of an altered chromophore-protein interaction in the artificial visual pigment cis-5,6-dihydroisorhodopsin and its photoproducts BSI, lumirhodopsin, and metarhodopsin-I

1991 • 50 citations

13-(Trifluoromethyl)retinal forms an active and far-red-shifted chromophore in bacteriorhodopsin

1981 • 48 citations

Regeneration of Rhodopsin and Bacteriorhodopsin

1981 • 48 citations

Primary photochemical event in bacteriorhodopsin: study with artificial pigments

1985 • 48 citations

Mechanism of activation of sensory rhodopsin I: evidence for a steric trigger.

1991 • 45 citations

Trans/13-cis isomerization is essential for both the photocycle and proton pumping of bacteriorhodopsin

1985 • 45 citations

Transmembrane location of retinal in bacteriorhodopsin by neutron diffraction

1990 • 45 citations

Electrostatic interaction between retinylidene chromophore and opsin in rhodopsin studied by fluorinated rhodopsin analogs

1987 • 45 citations

Bacteriorhodopsins containing cyanine dye chromophores. Support for the external point-charge model

1983 • 44 citations

What Makes Red Visual Pigments Red? A Resonance Raman Microprobe Study of Retinal Chromophore Structure in Iodopsin

1994 • 44 citations

Picosecond kinetic absorption and fluorescence studies of bovine rhodopsin with a fixed 11-ene

1983 • 44 citations

Photolysis intermediates of the artificial visual pigment cis-5,6-dihydro-isorhodopsin

1989 • 43 citations

Comparative study of phototactic and photophobic receptor chromophore properties in Chlamydomonas reinhardtii

1993 • 43 citations

11-cis-retinal, a molecule uniquely suited for vision

1991 • 43 citations

The chromophore binding space of opsin

1978 • 42 citations

Synthetic pigment analogues of the purple membrane protein

1977 • 40 citations

Allenic retinals and visual pigment analogues

1976 • 38 citations

Structure and Function of Several Anti-Dansyl Chimeric Antibodies Formed by Domain Interchanges between Human IgM and Mouse IgG2b

1995 • 37 citations

14-Fluorobacteriorhodopsin and other fluorinated and 14-substituted analogs. An extra, unusually red-shifted pigment formed during dark adaptation

1990 • 37 citations

Optical picosecond studies of bacteriorhodopsin containing a sterically fixed retinal

1984 • 36 citations

Photocurrents of dark‐adapted bacteriorhodopsin on black lipid membranes

1982 • 34 citations

ANALYZING THE RED‐SHIFT CHARACTERISTICS OF AZULENIC, NAPHTHYL, OTHER RING‐FUSED AND RETINYL PIGMENT ANALOGS OF BACTERIORHODOPSIN*

1993 • 33 citations

Octopus photoreceptor membranes. Surface charge density and pK of the Schiff base of the pigments

1990 • 33 citations

SYNTHESIS OF DOUBLY AND MULTIPLY ISOTOPICALLY LABELED RETINALS

1992 • 32 citations

The influence of the 13-methyl group of the retinal on the photoreaction of rhodopsin revealed by FTIR difference spectroscopy

1990 • 32 citations

Spectroscopic study of the batho-to-lumi transition during the photobleaching of rhodopsin using ring-modified retinal analogs

1991 • 31 citations

9, 13-dicis-Rhodopsin and its one-photon-one-double-bond isomerization

1988 • 30 citations

Reconstitution of a Proton Pump

1976 • 29 citations

Rapid charge separation and bathochromic absorption shift of flash-excited bacteriorhodopsins containing 13-cis or all-trans forms of substituted retinals

1987 • 27 citations

Seven new hindered isomeric rhodopsins

1984 • 27 citations

Wavelength regulation in iodopsin, a cone pigment

1989 • 27 citations

The pKa of the protonated Schiff bases of gecko cone and octopus visual pigments

1994 • 27 citations

Reduced Light-dependent Phosphorylation of an Analog Visual Pigment Containing 9-Demethylretinal as Its Chromophore

1995 • 27 citations

Diversion of the sign of phototaxis in a Chlamydomonas reinhardtii mutant incorporated with retinal and its analogs

1992 • 26 citations

Adamantyl allenic rhodopsin. Leniency of the ring binding site in bovine opsin

1980 • 26 citations

SHAPE OF THE CHROMOPHOIW BINDING SITE IN pharaonis PHOBORHODOPSIN FROM A STUDY USING RETINAL ANALOGS

1994 • 24 citations

Theory of rhodopsin activation: probable charge redistribution of excited state chromophore

1989 • 23 citations

Synthesis and binding studies of a photoaffinity label for bovine rhodopsin

1982 • 23 citations

Inhibition of rhodopsin regeneration by cyclohexyl derivatives

1982 • 22 citations

α‐retinal as a prosthetic group in bacteriorhodopsin

1980 • 22 citations

Structural Changes in Early Photolysis Intermediates of Rhodopsin from Time-Resolved Spectral Measurements of Artificial Pigments Sterically Hindered along the Chromophore Chain

1995 • 22 citations

Synthesis and vibrational analysis of a locked 14-s-cis conformer of retinal.

1992 • 22 citations

A novel rhodopsin analogue possessing the conformationally 6-s-cis-fixed retinylidene chromophore

1985 • 21 citations

The effect of variation of retinal polyene side-chain length on formation and function of bacteriorhodopsin analog pigments

1986 • 21 citations

Substituents at the C13 Position of Retinal and Their Influence on the Function of Bacteriorhodopsin

1985 • 21 citations

Ab Initio Study of 13C NMR Chemical Shifts for the Chromophores of Rhodopsin and Bacteriorhodopsin. 1. Theoretical Estimation of Their Ring-Chain Conformations

1994 • 21 citations

An artificial visual pigment with restricted carbon-9-carbon-11 motion forms normal photolysis intermediates

1986 • 21 citations

PROPERTIES OF SYNTHETIC BACTERIORHODOPSIN PIGMENTS. FURTHER PROBES OF THE CHROMOPHORE BINDING SITE

1986 • 20 citations

Opsin pigments formed with acyclic retinal analogues

1983 • 19 citations

Photocycles of bacteriorhodopsins containing 13-alkylsubstituted retinals

1988 • 19 citations

High-pH form of bovine rhodopsin

1992 • 19 citations

NANOSECOND LASER PHOTOLYSIS OF RHODOPSIN AND ISORHODOPSIN

1983 • 19 citations

Synthesis of optically active 3-diazoacetylretinals with triisopropylphenylsulfonylhydrazone

1988 • 19 citations

Properties of an Analogue Pigment of Bacteriorhodopsin Synthesized with Naphthylretinal

1984 • 19 citations

Differences in the photobleaching process between 7-cis- and 11-cis-rhodopsins: a unique interaction change between the chromophore and the protein during the lumi-meta I transition

1991 • 19 citations

5-(Trifluoromethyl)bacteriorhodopsin does not translocate protons

1986 • 18 citations

Analog pigment studies of chromophore-protein interactions in metarhodopsins

1989 • 18 citations

Activation of phosphodiesterase by rhodopsin and its analogues

1983 • 18 citations

Sterically Fixed Retinal-Analogue Prevents Proton-Pumping Activity in Bacteriorhodopsin

1984 • 18 citations

Photoaffinity labeling of bovine rhodopsin

1984 • 18 citations

Chapter 7 The stereochemistry of vision

1982 • 18 citations

Early photolysis intermediates of the artificial visual pigment 13-demethylrhodopsin

1990 • 17 citations

ISOMERS OF 3,7,11‐TRIMETHYLDODECA‐2,4,6,8,10‐ PENTAENAL (A LINEAR ANALOGUE OF RETINAL) and LOWER HOMOLOGUES IN THEIR INTERACTION WITH BOVINE OPSIN and BACTERIOOPSIN

1985 • 17 citations

The primary event in vision investigated by time-resolved fluorescence spectroscopy

1985 • 17 citations

Evidence for a common batho intermediate of rhodopsin and isorhodopsin

1988 • 16 citations

A SPIN LABELED RETINAL PIGMENT ANALOGUE OF THE PURPLE MEMBRANE

1981 • 16 citations

Effects of modifications of the retinal beta-ionone ring on archaebacterial sensory rhodopsin I

1990 • 16 citations

Structure of the retinal chromophore in 7,9-dicis-rhodopsin

1990 • 16 citations

Interaction of aromatic retinal analogs with apopurple membranes of Halobacterium halobium

1984 • 16 citations

Transduction noise induced by 4-hydroxy retinals in rod photoreceptors

1990 • 16 citations

INCORPORATION OF 11,12‐DIHYDRORETINAL INTO THE RETINAE OF VITAMIN A DEPRIVED RATS

1981 • 15 citations

Neither the retinal ring nor the ring double bond is required for proton pumping in bacteriorhodopsin: acyclic retinal bacterioopsin analogs

1984 • 15 citations

RING OXIDIZED RETINALS FORM UNUSUAL BACTERIORHODOPSIN ANALOGUE PIGMENTS*

1991 • 15 citations

Retinoids and Related Compounds. Part 16. Synthesis of (+)-(4S)- and (-)-(4R)-(11Z)-4-Hydroxyretinals and Determination of the Absolute Stereochemistry of a Visual Pigment Chromophore in the Firefly Squid, Watasenia scintillans

1994 • 15 citations

Orientation of the Retinal 9-Methyl Group in Bacteriorhodopsin As Studied by Photoaffinity Labeling

1994 • 15 citations

(5‐demethyl)‐Bacteriorhodopsin analogue: its formation and light‐driven proton pump action

1983 • 14 citations

A bacteriorhodopsin analog containing the retinal nitroxide free radical

1981 • 14 citations

(1R)‐ and (1S)‐5‐demethyl‐8,16‐methanobacteriorhodopsin and its properties. The synthesis and spectroscopy of 5‐demethyl‐8,16‐methanoretinal in optically active and isotopic forms

1992 • 13 citations

Acetylenic retinals form functional bacteriorhodopsins but do not form bovine rhodopsins

1984 • 13 citations

ISOMER COMPOSITION and SPECTRA OF THE DARK and LIGHT ADAPTED FORMS OF ARTIFICIAL BACTERIORHODOPSINS*

1991 • 12 citations

Thein vivocleavage of carotenoids into retinoids in Chlamydomonas reinhardtii

1994 • 12 citations

Methoxyretinals in bacteriorhodopsin

1988 • 11 citations

VISUAL PIGMENTS AND BACTERIORHODOPSINS FORMED FROM AROMATIC RETINAL ANALOGS

1984 • 11 citations

Divergent pathways in photobleaching of 7,9-dicis-rhodopsin and 9,11-dicis-12-fluororhodopsin: One-photon-two-bond and one-photon-one-bond isomerization

1993 • 11 citations

Picosecond time-resolved absorption and fluorescence dynamics in the artificial bacteriorhodopsin pigment BR6.11

1993 • 11 citations

Fluorine-19 NMR evidence for restricted rotation of the retinyl chromophore in doubly labeled visual pigment analogs

1992 • 11 citations

Absorption spectrum of cattle hypsorhodopsin

1983 • 10 citations

Synthesis of six novel retinals and their interaction with bacterioopsin

1994 • 10 citations

Probing of the Retinal Binding Site of Bacteriorhodopsin by Affinity Labeling

1994 • 9 citations

LOW‐TEMPERATURE TRAPPING OF EARLY PHOTOINTERMEDIATES OF α‐ISORHODOPSIN

1995 • 9 citations

Rhodopsins containing 6- to 9-membered rings. The triggering process of visual transduction

1994 • 9 citations

Biochemical properties of 9-cis- and all-trans-retinoylopsins

1985 • 8 citations

Probes which reflect the distance between the retinal chromophore and membrane surface in bacteriorhodopsin (bR). Direction of retinal 9-methyl in bR

1989 • 7 citations

Synthesis of 13-Acetoxy-13-demethylretinal, Its Pigment Formation with Bacteriopsin, and Apparent Dark-Inactivating Effect on the Pigment

1995 • 7 citations

PURPLE MEMBRANE ANALOGS SYNTHESIZED FROM C₁₇ ALDEHYDE

1981 • 7 citations

Isomers, visual pigment, and bacteriorhodopsin analogs of 3,7,13-trimethyl-10-isopropyl-2,4,6,8,10-tetradecapentaenal and 3,7,11-trimethyl-10-isopropyl-2,4,6,8,10-dodecapentaenal (two ring open retinal analogs)

1989 • 6 citations

AZIDOTETRAFLUOROPHENYL RETINAL ANALOGUE: SYNTHESIS AND BACTERIORHODOPSIN PIGMENT FORMATION

1994 • 6 citations

The influence of the 5-methyl group in bacteriorhodopsin

1993 • 6 citations

Photochemical properties of naphthylbacteriorhodopsins differing in their protein-chromophore interactions

1988 • 6 citations

Regulation of the 6‐s Equilibrium Conformation of Retinal in Bacteriorhodopsin by Substitution at C‐5; 5‐Methoxy‐ and 5‐Ethylretinalbacteriorhodopsin

1987 • 6 citations

Ab initio study of the ¹³C NMR chemical shifts for some polyene compounds as models for the chromophore of rhodopsin

1992 • 6 citations

STRUCTURE OF HYPSORHODOPSIN: ANALYSIS BY FOURIER TRANSFORM INFRARED SPECTROSCOPY AT 10 K

1992 • 5 citations