In vivo selection of retrovirally transduced hematopoietic stem cells

Developmental potential and dynamic behavior of hematopoietic stem cells

1986 • 888 citations

Introduction of a selectable gene into primitive stem cells capable of long-term reconstitution of the hemopoietic system of W/W mice

1985 • 663 citations

Clonal and systemic analysis of long-term hematopoiesis in the mouse.

1990 • 577 citations

Introduction of new genetic material into pluripotent haematopoietic stem cells of the mouse

1984 • 527 citations

Selection of Drug-Resistant Bone Marrow Cells in Vivo After Retroviral Transfer of Human MDR 1

1992 • 500 citations

Retrovirally marked CD34-enriched peripheral blood and bone marrow cells contribute to long-term engraftment after autologous transplantation

1995 • 496 citations

Gene marking to determine whether autologous marrow infusion restores long-term haemopoiesis in cancer patients

1993 • 434 citations

Lack of expression from a retroviral vector after transduction of murine hematopoietic stem cells is associated with methylation in vivo.

1994 • 415 citations

Competitive repopulation: a new assay for long-term stem cell functional capacity

1980 • 332 citations

Retroviral-Mediated Transfer of the Green Fluorescent Protein Gene Into Murine Hematopoietic Cells Facilitates Scoring and Selection of Transduced Progenitors In Vitro and Identification of Genetically Modified Cells In Vivo

1997 • 230 citations

Treatment of genetic defects in hematopoietic cell function by gene transfer

1991 • 225 citations

Retroviral vectors containing putative internal ribosome entry sites: development of a polycistronic gene transfer system and applications to human gene therapy

1992 • 211 citations

Transfer and expression of the human multiple drug resistance gene into live mice.

1992 • 210 citations

Simplified typing of mouse hemoglobin (Hbb) phenotypes using cystamine

1978 • 200 citations

Nucleoside transport in normal and neoplastic cells

1993 • 167 citations

Transplantable myeloproliferative disease induced in mice by an interleukin 6 retrovirus.

1992 • 167 citations

Restoration of lymphocyte function in Janus Kinase 3-deficient mice by retroviral-mediated gene transfer

1998 • 143 citations

Serial transplantation of methotrexate-resistant bone marrow: protection of murine recipients from drug toxicity by progeny of transduced stem cells

1990 • 141 citations

Methotrexate-resistant Variants of Human Dihydrofolate Reductase with Substitutions of Leucine 22

1995 • 140 citations

Selection for G156A O6-methylguanine DNA methyltransferase gene-transduced hematopoietic progenitors and protection from lethality in mice treated with O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea.

1997 • 115 citations

Selection of retrovirally transduced hematopoietic cells using CD24 as a marker of gene transfer

1994 • 108 citations

A gene transfer strategy for making bone marrow cells resistant to trimetrexate

1996 • 106 citations

Sustained High-Level Reconstitution of the Hematopoietic System by Preselected Hematopoietic Cells Expressing a Transduced Cell-Surface Antigen

1997 • 80 citations

A three-dimensional model of the fluid dynamics of radio-trail sources

1984 • 70 citations

Sensitization of Hematopoietic Stem and Progenitor Cells to Trimetrexate Using Nucleoside Transport Inhibitors

1997 • 69 citations

Long-term protection of recipient mice from lethal doses of methotrexate by marrow infected with a double-copy vector retrovirus containing a mutant dihydrofolate reductase.

1994 • 62 citations

Development of a retroviral construct containing a human mutated dihydrofolate reductase cDNA for hematopoietic stem cell transduction

1994 • 59 citations

Hemodynamic and neurohumoral effects of various grades of selective adenosine transport inhibition in humans. Implications for its future role in cardioprotection.

1995 • 48 citations

Total marrow failure induced by pegylated stem-cell factor administered before 5-fluorouracil

1994 • 47 citations

Development of a retroviral construct containing a human mutated dihydrofolate reductase cDNA for hematopoietic stem cell transduction

1994 • 45 citations

Human alkyltransferase-transduced murine myeloid progenitors are enriched in vivo by BCNU treatment of transplanted mice.

1997 • 43 citations

The Hematological Effects of Folate Analogs: Implications for Using the Dihydrofolate Reductase Gene forIn VivoSelection

1996 • 42 citations

Therapy of mouse leukemia L1210 with combinations of nebularine and nitrobenzylthioinosine 5'-monophosphate.

1981 • 37 citations

Methotrexate and dipyridamole combination chemotherapy based upon inhibition of nucleoside salvage in humans.

1989 • 36 citations

Reversal of 1,3-bis(2-chloroethyl)-1-nitrosourea-induced severe immunodeficiency by transduction of murine long-lived hemopoietic progenitor cells using O6-methylguanine DNA methyltransferase complementary DNA.

1997 • 34 citations

Cytokine Prestimulation as a Gene Therapy Strategy: Implications for Using the MDR1 Gene as a Dominant Selectable Marker

1997 • 33 citations