Nucleoside transport in normal and neoplastic cells

Biochemical strategy of cancer cells and the design of chemotherapy: G. H. A. Clowes Memorial Lecture.

1983 • 552 citations

Nucleoside and nucleobase transport in animal cells

1988 • 367 citations

Permeation of Nucleosides, Nucleic Acid Bases, and Nucleotides in Animal Cells

1980 • 312 citations

Transport of nucleoside drugs in animal cells

1981 • 241 citations

Cloning and functional expression of a mammalian Na+/nucleoside cotransporter. A member of the SGLT family.

1992 • 163 citations

Sodium-dependent nucleoside transport in mouse intestinal epithelial cells. Two transport systems with differing substrate specificities.

1988 • 159 citations

Nucleoside transport in cultured mammalian cells multiple forms with different sensitivity to inhibition by nitrobenzylthioinosine or hypoxanthine

1984 • 137 citations

Heterogeneity of nucleoside transport in mammalian cells. Two types of transport activity in L1210 and other cultured neoplastic cells.

1983 • 118 citations

Sodium-dependent nucleoside transport in choroid plexus from rabbit. Evidence for a single transporter for purine and pyrimidine nucleosides.

1992 • 109 citations

Multiple sodium-dependent nucleoside transport systems in bovine renal brush-border membrane vesicles

1991 • 105 citations

Potentiation of methotrexate toxicity by dipyridamole.

1984 • 88 citations

Nucleoside transport in L1210 murine leukemia cells. Evidence for three transporters.

1990 • 86 citations

Membrane transport of antineoplastic agents

1986 • 83 citations

Effects of acivicin and dipyridamole on hepatoma 3924A cells.

1983 • 83 citations

Characterization of sodium-dependent nucleoside transport in rabbit intestinal brush-border membrane vesicles

1989 • 82 citations

Nucleoside transport in rat erythrocytes: two components with differences in sensitivity to inhibition by nitrobenzylthioinosine andp-chloromercuriphenyl sulfonate

1986 • 81 citations

Concentrative uridine transport by murine splenocytes: kinetics, substrate specificity, and sodium dependency.

1987 • 81 citations

Sodium gradient-energized concentrative transport of adenosine in renal brush border vesicles

1984 • 78 citations

Sodium-dependent, concentrative nucleoside transport in cultured intestinal epithelial cells

1986 • 76 citations

Uridine uptake by isolated intestinal epithelial cells of guinea pig

1984 • 75 citations

Nucleoside transport in Walker 256 rat carcinosarcoma and S49 mouse lymphoma cells. Differences in sensitivity to nitrobenzylthioinosine and thiol reagents

1985 • 70 citations

Uphill transport of pyrimidine nucleosides in renal brush border vesicles

1985 • 69 citations

Nucleoside transport in brush border membrane vesicles from human kidney

1992 • 64 citations

Nucleoside transport in choroid plexus: Mechanism and specificity

1982 • 61 citations

Enhancement of the sensitivity of human colon cancer cells to growth inhibition by acivicin achieved through inhibition of nucleic acid precursor salvage by dipyridamole.

1984 • 59 citations

Purification of the human erythrocyte nucleoside transporter by immunoaffinity chromatography.

1988 • 58 citations

Mechanism of synergy between N-phosphonacetyl-L-aspartate and dipyridamole in a human ovarian carcinoma cell line.

1985 • 57 citations

Induction of the differentiation of HL-60 cells by phorbol 12-myristate 13-acetate activates a Na+-dependent uridine-transport system. Involvement of protein kinase C

1991 • 57 citations

Characterization of sodium-dependent and sodium-independent nucleoside transport systems in rabbit brush-border and basolateral plasma-membrane vesicles from the renal outer cortex

1989 • 56 citations

Phase I clinical trial of a combination of dipyridamole and acivicin based upon inhibition of nucleoside salvage.

1988 • 44 citations

Salvage capacity of hepatoma 3924A and action of dipyridamole

1983 • 44 citations

Characterization of Na+-dependent, active nucleoside transport in rat and mouse peritoneal macrophages, a mouse macrophage cell line and normal rat kidney cells

1990 • 44 citations

Na+-dependent and -independent transport of uridine and its phosphorylation in mouse spleen cells

1989 • 43 citations

Phase I trial of 5-fluorouracil and dipyridamole administered by seventy-two-hour concurrent continuous infusion.

1990 • 43 citations

Salvage pathways as targets of chemotherapy

1987 • 41 citations

Autologous Bone-marrow Transplantation

1987 • 41 citations

Uptake of Thymidine into Isolated Rat Hepatocytes. Evidence for Two Transport Systems

1978 • 40 citations

Dipyridamole inhibits reversion by thymidine of methotrexate effect and increases drug uptake in Sarcoma 180 cells.

1984 • 40 citations

Interference with nucleoside transport in mouse lymphoma cells proliferating in culture.

1972 • 38 citations

Methotrexate and dipyridamole combination chemotherapy based upon inhibition of nucleoside salvage in humans.

1989 • 36 citations

Comparative pharmacology of the nitrobenzylthioguanosine-sensitive and -resistant nucleoside transport mechanisms of Ehrlich ascites tumor cells.

1991 • 36 citations

Sodium-dependent and equilibrative nucleoside transport systems in L1210 mouse leukemia cells: effect of inhibitors of equilibrative systems on the content and retention of nucleosides.

1990 • 32 citations

Phase I trial of dipyridamole with 5-fluorouracil and folinic acid.

1990 • 32 citations

Isolation and characterization of an L1210 cell line retaining the sodium-dependent carrier cif as its sole nucleoside transport activity.

1990 • 28 citations

Modulation of the activity of PALA by dipyridamole.

1985 • 27 citations

Azidothymidine and dipyridamole as biochemical response modifiers: synergism with methotrexate and 5-fluorouracil in human colon and pancreatic carcinoma cells.

1992 • 27 citations

Na+-dependent, active and Na+-independent, facilitated transport of formycin B in mouse spleen lymphocytes

1990 • 26 citations

Dipyridamole enhancement of toxicity to L1210 cells by deoxyadenosine and deoxycoformycin combinations in vitro.

1984 • 23 citations

Phase I trial of combination therapy of cancer with N-phosphanacetyl-L-aspartic acid and dipyridamole

1987 • 21 citations

Evidence for Separate Carriers for Purine Nucleosides and for Pyrimidine Nucleosides in the Renal Brush Border Membrane

1990 • 20 citations

Sodium-adenosine cotransport in brush-border membranes from rabbit ileum

1990 • 19 citations

Transport of adenosine by renal brush border membranes

1983 • 19 citations

Sodium-dependent, concentrative nucleoside transport in Walker 256 rat carcinosarcoma cells

1991 • 17 citations

Similar characteristics of folate analogue transport in vitro in contrast to varying dihydrofolate reductase levels in epithelial cells at different stages of maturation in mouse small intestine.

1984 • 16 citations

Phase II trial of oral methotrexate and dipyridamole in colorectal carcinoma.

1987 • 15 citations

Characterization of conditions in which dipyridamole enhances methotrexate toxicity in L1210 cells.

1987 • 13 citations

Characterization of monoclonal antibodies that recognize band 4.5 polypeptides associated with nucleoside transport in pig erythrocytes

1987 • 13 citations

Sodium-dependent and inhibitor-insensitive uptake of adenosine by mouse peritoneal exudate cells

1990 • 11 citations

A phase II trial of PALA+dipyridamole in patients with advanced soft-tissue sarcoma

1991 • 11 citations

Effect of Nucleoside Transport Inhibitors on Thymidine Salvage and the Toxicity of Nucleoside Analogs in Mouse Bone Marrow Granulocyte-Macrophage Progenitor Cells

1991 • 10 citations

Prevention of 1-beta-D arabinofuranosylcytosine toxicity by 4-nitrobenzyl-6-thioinosine or dipyridamole in human leukemia cell lines.

1988 • 9 citations

Multimodal Biochemical Modulation of 5-Fluorouracil Activity in Advanced Colorectal Cancer with Allopurinol, Folinic Acid and Dipyridamol

1990 • 7 citations

High-dose leucovorin, fluorouracil and oral dipyridamole in the treatment of advanced colorectal cancer.

1991 • 7 citations

Antitumor activity of N-phosphonacetyl-l-aspartic acid in combination with nitrobenzylthioinosine

1984 • 7 citations

Expression of Sodium-Dependent Nucleoside Transporters in Xenopus Oocytes

1991 • 7 citations

5-Fluorouracil and Dipyridamole in Metastatic Breast Cancer: A Pilot Study

1989 • 5 citations

Antibodies and Proteases as Probes of the Structures of Mammalian Nucleoside Transporters

1991 • 1 citations