Vector unpacking as a potential barrier for receptor-mediated polyplex gene delivery

A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine.

1995 • 6,103 citations

POLYAMINES

1984 • 2,996 citations

Polyamidoamine cascade polymers mediate efficient transfection of cells in culture

1993 • 1,186 citations

High efficiency transformation by direct microinjection of DNA into cultured mammalian cells

1980 • 1,005 citations

Receptor-mediated in vitro gene transformation by a soluble DNA carrier system.

1987 • 841 citations

Tracking the intracellular path of poly(ethylenimine)/DNA complexes for gene delivery

1999 • 819 citations

Stepwise dismantling of adenovirus 2 during entry into cells

1993 • 810 citations

Size matters: Molecular weight affects the efficiency of poly(ethylenimine) as a gene delivery vehicle

1999 • 801 citations

Polyethylenimine but Not Cationic Lipids Promotes Transgene Delivery to the Nucleus in Mammalian Cells

1998 • 711 citations

Introduction to the polyamines

1971 • 682 citations

The influence of endosome-disruptive peptides on gene transfer using synthetic virus-like gene transfer systems.

1994 • 668 citations

Mechanism of oligonucleotide release from cationic liposomes.

1996 • 617 citations

Activation of the Complement System by Synthetic DNA Complexes: A Potential Barrier for Intravenous Gene Delivery

1996 • 583 citations

Adenovirus enhancement of transferrin-polylysine-mediated gene delivery.

1991 • 431 citations

Interactions of polymeric and liposomal gene delivery systems with extracellular glycosaminoglycans: physicochemical and transfection studies

1999 • 342 citations

High-efficiency receptor-mediated delivery of small and large (48 kilobase gene constructs using the endosome-disruption activity of defective or chemically inactivated adenovirus particles.

1992 • 317 citations

Delivery of drugs, proteins and genes into cells using transferrin as a ligand for receptor-mediated endocytosis

1994 • 278 citations

DNA vector chemistry: The covalent attachment of signal peptides to plasmid DNA

1998 • 271 citations

Deoxyribonucleic acid-polylysine complexes. Structure and nucleotide specificity

1969 • 236 citations

Cell movement elicited by epidermal growth factor receptor requires kinase and autophosphorylation but is separable from mitogenesis

1994 • 234 citations

Branched Cationic Peptides for Gene Delivery: Role of Type and Number of Cationic Residues in Formation and in Vitro Activity of DNA Polyplexes

1999 • 227 citations

The interaction of plasmid DNA with polyamidoamine dendrimers: mechanism of complex formation and analysis of alterations induced in nuclease sensitivity and transcriptional activity of the complexed DNA

1997 • 226 citations

Adenoviral vectors for gene transfer

1997 • 209 citations

Isolation and characterization of neutralizing monoclonal antibodies to vaccinia virus

1985 • 174 citations

Kinetics and mechanism of interpolyelectrolyte exchange and addition reactions

1992 • 160 citations

Targeting DNA to Cells with Basic Fibroblast Growth Factor (FGF2)

1996 • 153 citations

Gene delivery and expression mediated by an integrin-binding peptide.

1995 • 143 citations

Optimization of Cell Surface Binding Enhances Efficiency and Specificity of Molecular Conjugate Gene Delivery

1998 • 143 citations

Enhanced resistance to nuclease degradation of nucleic acids complexed to asialoglycoprotein-polylysine carriers

1994 • 143 citations

Biochemical and Functional Characterization of DNA Complexes Capable of Targeting Genes to Hepatocytes via the Asialoglycoprotein Receptor

1997 • 129 citations

Mechanisms of virus uncoating

1994 • 114 citations

Overexpression of Human Methylmalonyl CoA Mutase in Mice afterIn VivoGene Transfer with Asialoglycoprotein/Polylysine/DNA Complexes

1994 • 104 citations

Chloroquine and amphipathic peptide helices show synergistic transfection in vitro

1998 • 93 citations

The reduction of the positive charges of polylysine by partial gluconoylation increases the transfection efficiency of polylysine/DNA complexes

1997 • 86 citations

Chain Length of the Polylysine in Receptor-targeted Gene Transfer Complexes Affects Duration of Reporter Gene Expression Both in Vitro and in Vivo

1999 • 68 citations

Protective antibodies inhibit reovirus internalization and uncoating by intracellular proteases

1994 • 45 citations

Poly(<scp>L</scp>–lysine)–DNA interactions in NaCl solutions: B → C and B → ψ Transitions

1977 • 38 citations

Growth of the parvovirus minute virus of mice MVMp3 in EL4 lymphocytes is restricted after cell entry and before viral DNA amplification: cell-specific differences in virus uncoating in vitro

1997 • 30 citations

Thermal denaturation of calf thymus DNA: existence of a GC-richer fraction

1974 • 29 citations

The stability of polyelectrolyte complexes of Calf‐Thymus DNA and synthetic polycations: Theoretical and experimental investigations

1997 • 26 citations

IgG-neutralized Influenza Virus Undergoes Primary, but Not Secondary Uncoating in vivo

1989 • 22 citations

Gene transfer into hepatoma cell lines via the serpin enzyme complex receptor

1997 • 22 citations

Accessibility of chromatin to DNA polymerase I and location of the F1 histone

1975 • 14 citations

Uptake and intracellular trafficking of asialoglycoprotein-polylysine-DNA complexes in isolated rat hepatocytes.

1996 • 9 citations

Use of the Green Fluorescent Protein as a Quantitative Reporter of Epidermal Growth Factor Receptor-Mediated Gene Delivery

1997 • 8 citations

Fate of DNA targeted to hepatocytes by asialoglycoprotein polylysine conjugates.

1995 • 4 citations