BRIT1 regulates early DNA damage response, chromosomal integrity, and cancer

Gene expression profiling predicts clinical outcome of breast cancer

2002 • 9,314 citations

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

2003 • 3,385 citations

Molecular Mechanisms of Mammalian DNA Repair and the DNA Damage Checkpoints

2004 • 3,161 citations

The DNA damage response: putting checkpoints in perspective

2000 • 3,147 citations

Cell-cycle checkpoints and cancer

2004 • 2,699 citations

Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer

2005 • 2,658 citations

DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

2005 • 2,633 citations

Sensing DNA Damage Through ATRIP Recognition of RPA-ssDNA Complexes

2003 • 2,569 citations

ATM and related protein kinases: safeguarding genome integrity

2003 • 2,516 citations

High resolution analysis of DNA copy number variation using comparative genomic hybridization to microarrays

1998 • 2,266 citations

A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage

2000 • 2,052 citations

Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

2005 • 1,975 citations

ATM Activation by DNA Double-Strand Breaks Through the Mre11-Rad50-Nbs1 Complex

2005 • 1,364 citations

Genomic Instability in Mice Lacking Histone H2AX

2002 • 1,343 citations

Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer

2005 • 1,225 citations

The hMre11/hRad50 Protein Complex and Nijmegen Breakage Syndrome: Linkage of Double-Strand Break Repair to the Cellular DNA Damage Response

1998 • 1,220 citations

ATM and DNA-PK Function Redundantly to Phosphorylate H2AX after Exposure to Ionizing Radiation

2004 • 979 citations

Assembly of microarrays for genome-wide measurement of DNA copy number

2001 • 948 citations

Dynamic Changes of BRCA1 Subnuclear Location and Phosphorylation State Are Initiated by DNA Damage

1997 • 910 citations

MDC1 is a mediator of the mammalian DNA damage checkpoint

2003 • 862 citations

The BRCT Domain Is a Phospho-Protein Binding Domain

2003 • 821 citations

Toward Maintaining the Genome: DNA Damage and Replication Checkpoints

2002 • 773 citations

Interfaces Between the Detection, Signaling, and Repair of DNA Damage

2002 • 693 citations

Association of BRCA1 with the hRad50-hMre11-p95 Complex and the DNA Damage Response

1999 • 621 citations

ATM and ATR: networking cellular responses to DNA damage

2001 • 595 citations

ATR Regulates Fragile Site Stability

2002 • 560 citations

53BP1, a Mediator of the DNA Damage Checkpoint

2002 • 559 citations

H2AX Haploinsufficiency Modifies Genomic Stability and Tumor Susceptibility

2003 • 545 citations

MDC1 is required for the intra-S-phase DNA damage checkpoint

2003 • 508 citations

Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin

2002 • 492 citations

Histone H2AX

2003 • 479 citations

Identification of Microcephalin, a Protein Implicated in Determining the Size of the Human Brain

2002 • 475 citations

Tumor Suppressor P53 Binding Protein 1 (53bp1) Is Involved in DNA Damage–Signaling Pathways

2001 • 474 citations

Pathological and molecular aspects of prostate cancer

2003 • 474 citations

Multiple Tumor Suppressor Pathways Negatively Regulate Telomerase

2003 • 433 citations

Replication protein A-mediated recruitment and activation of Rad17 complexes

2003 • 416 citations

53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer

2002 • 404 citations

p53 Binding Protein 53BP1 Is Required for DNA Damage Responses and Tumor Suppression in Mice

2003 • 404 citations

The role of DNA breaks in genomic instability and tumorigenesis

2003 • 352 citations

Checking on the fork: the DNA-replication stress-response pathway

2002 • 340 citations

The cellular response to DNA double-strand breaks: defining the sensors and mediators

2003 • 336 citations

MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways

2003 • 332 citations

A targeted disruption of the murine Brca1 gene causes γ-irradiation hypersensitivity and genetic instability

1998 • 325 citations

The relationship between the roles of BRCA genes in DNA repair and cancer predisposition

2002 • 319 citations

The MRN complex: coordinating and mediating the response to broken chromosomes

2003 • 289 citations

Array-based comparative genomic hybridization for genome-wide screening of DNA copy number in bladder tumors.

2003 • 260 citations

Chk1 is haploinsufficient for multiple functions critical to tumor suppression

2004 • 244 citations

DNA damage tumor suppressor genes and genomic instability

2003 • 230 citations

Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models

2005 • 226 citations

Preferential binding of ATR protein to UV-damaged DNA

2002 • 170 citations

Microcephalin Is a DNA Damage Response Protein Involved in Regulation of CHK1 and BRCA1

2004 • 170 citations

Regulation of mitotic entry by microcephalin and its overlap with ATR signalling

2006 • 168 citations

BRIT1/MCPH1 is a DNA damage responsive protein that regulates the Brca1–Chk1 pathway, implicating checkpoint dysfunction in microcephaly

2005 • 167 citations

Mutation in Rpa1 results in defective DNA double-strand break repair, chromosomal instability and cancer in mice

2005 • 155 citations

Mechanisms leading to chromosomal instability

2004 • 141 citations

Functional Interaction of H2AX, NBS1, and p53 in ATM-Dependent DNA Damage Responses and Tumor Suppression

2005 • 127 citations

NFBD1/MDC1 regulates ionizing radiation‐induced focus formation by DNA checkpoint signaling and repair factors

2003 • 124 citations

ATR functions as a gene dosage-dependent tumor suppressor on a mismatch repair-deficient background

2004 • 108 citations

Genomic instability and cancer: Networks involved in response to DNA damage

2005 • 106 citations

Pooled Analysis of Loss of Heterozygosity in Breast Cancer: a Genome Scan Provides Comparative Evidence for Multiple Tumor Suppressors and Identifies Novel Candidate Regions

2003 • 105 citations

Invasive micropapillary carcinoma of the breast is associated with chromosome 8 abnormalities detected by comparative genomic hybridization

2002 • 84 citations

Comparison of Serous and Mucinous Ovarian Carcinomas: Distinct Pattern of Allelic Loss at Distal 8p and Expression of Transcription Factor GATA-4

2001 • 70 citations

Replication protein A and γ-H2AX foci assembly is triggered by cellular response to DNA double-strand breaks

2004 • 69 citations

Genomic instability and endoreduplication triggered byRAD17deletion

2003 • 67 citations

Genome-wide allelotype analysis of sporadic primary nasopharyngeal carcinoma from southern China.

2000 • 66 citations

Prostate Cancer : Biology, Genetics, and the New Therapeutics

2007 • 61 citations

Mutation of the mouse Rad17 gene leads to embryonic lethality and reveals a role in DNA damage-dependent recombination

2004 • 60 citations

Prostate cancer: biology, genetics, and the new therapeutics

2002 • 59 citations

NBS1 Knockdown by Small Interfering RNA Increases Ionizing Radiation Mutagenesis and Telomere Association in Human Cells

2005 • 58 citations

High‐density allelotyping of chromosome 8p in hepatocellular carcinoma and clinicopathologic correlation

2002 • 50 citations

High frequency of allelic imbalance at regions of chromosome arm 8p in ovarian carcinoma

2001 • 39 citations

Tumor Suppressor Genes in Prostate Cancer

2001 • 29 citations

Eukaryotic DNA damage surveillance and repair

2004 • 25 citations

NFBD1/Mdc1 Mediates ATR-Dependent DNA Damage Response

2005 • 21 citations

DNA Damage by the Enediyne C-1027 Results in the Inhibition of DNA Replication by Loss of Replication Protein A Function and Activation of DNA-Dependent Protein Kinase

2001 • 18 citations