Mammalian and Yeast ras Gene Products: Biological Function in Their Heterologous Systems

Mechanism of activation of a human oncogene

1982 • 1,417 citations

A point mutation is responsible for the acquisition of transforming properties by the T24 human bladder carcinoma oncogene

1982 • 1,398 citations

Monoclonal antibodies to the p21 products of the transforming gene of Harvey murine sarcoma virus and of the cellular ras gene family

1982 • 836 citations

RNA tumor viruses

1982 • 833 citations

Induction of mammary carcinomas in rats by nitroso-methylurea involves malignant activation of H-ras-1 locus by single point mutations

1983 • 719 citations

Comparative biochemical properties of normal and activated human ras p21 protein

1984 • 713 citations

Activation of the T24 bladder carcinoma transforming gene is linked to a single amino acid change

1982 • 706 citations

Intrinsic GTPase activity distinguishes normal and oncogenic ras p21 molecules.

1984 • 607 citations

The p21 ras C-terminus is required for transformation and membrane association

1984 • 590 citations

The product of ras is a GTPase and the T24 oncogenic mutant is deficient in this activity

1984 • 539 citations

Structure and activation of the human N-ras gene

1983 • 538 citations

Malignant transformation of early passage rodent cells by a single mutated human oncogene

1984 • 479 citations

Genes in S. cerevisiae encoding proteins with domains homologous to the mammalian ras proteins

1984 • 471 citations

Genetic analysis of yeast RAS1 and RAS2 genes

1984 • 460 citations

Localization of the src gene product of the Harvey strain of MSV to plasma membrane of transformed cells by electron microscopic immunocytochemistry

1980 • 404 citations

Harvey murine sarcoma virus p21 ras protein: biological and biochemical significance of the cysteine nearest the carboxy terminus.

1984 • 403 citations

Dual evolutionary origin for the rat genetic sequences of Harvey murine sarcoma virus

1980 • 387 citations

Acquisition of transforming properties by alternative point mutations within c-bas/has human proto-oncogene

1983 • 385 citations

Structure and organization of the human Ki-ras proto-oncogene and a related processed pseudogene

1983 • 360 citations

The transforming proteins of Rous sarcoma virus, Harvey sarcoma virus and Abelson virus contain tightly bound lipid

1982 • 357 citations

ras-Related gene sequences identified and isolated from Saccharomyces cerevisiae

1983 • 345 citations

Functional homology of mammalian and yeast RAS genes

1985 • 324 citations

Guanine nucleotide-binding activity as an assay for src protein of rat-derived murine sarcoma viruses

1979 • 315 citations

Analysis of two divergent rat genomic clones homologous to the transforming gene of Harvey murine sarcoma virus.

1981 • 302 citations

Helper-independent transformation by unintegrated Harvey sarcoma virus DNA

1978 • 277 citations

Nucleotide Sequence of the p21 Transforming Protein of Harvey Murine Sarcoma Virus

1982 • 272 citations

Nucleotide Sequence of the Oncogene Encoding the p21 Transforming Protein of Kirsten Murine Sarcoma Virus

1982 • 256 citations

Requirement of either of a pair of ras-related genes of Saccharomyces cerevisiae for spore viability

1984 • 228 citations

Yeast and mammalian ras proteins have conserved biochemical properties

1985 • 195 citations

mRNA levels for the fermentative alcohol dehydrogenase of Saccharomyces cerevisiae decrease upon growth on a nonfermentable carbon source.

1983 • 184 citations

The drosophila ras oncogenes: Structure and nucleotide sequence

1984 • 175 citations

RAS2 of Saccharomyces cerevisiae is required for gluconeogenic growth and proper response to nutrient limitation.

1985 • 168 citations

Characterization of the phosphorylation sites and the surrounding amino acid sequences of the p21 transforming proteins coded for by the Harvey and Kirsten strains of murine sarcoma viruses.

1982 • 135 citations

Molecular cloning and the total nucleotide sequence of the human c-Ha-ras-1 gene activated in a melanoma from a Japanese patient.

1984 • 131 citations

Nucleotide sequence of tworas^Hrelated-genes isolated from the yeastSaccharomyces cerevisiae

1984 • 118 citations

Spontaneous activation of a human proto-oncogene.

1983 • 114 citations

Yeast gene CDC8 encodes thymidylate kinase and is complemented by herpes thymidine kinase gene TK.

1984 • 109 citations

Oncogenes and Cancer: The p21rasGenes

1984 • 97 citations

Isolation of a gene from Drosophila by complementation in yeast

1981 • 95 citations

Mechanism of activation of an N-ras oncogene of SW-1271 human lung carcinoma cells.

1984 • 88 citations

Chimeric plasmids for cloning of deoxyribonucleic acid sequences in Saccharomyces cerevisiae

1979 • 77 citations

Autophosphorylation of v-Ha-ras p21 is modulated by amino acid residue 12.

1984 • 66 citations

Saccharomyces cerevisiae synthesizes proteins related to the p21 gene product of ras genes found in mammals.

1984 • 42 citations

Expression and characterization of ras mRNAs from Saccharomyces cerevisiae.

1984 • 30 citations