D2 and 5HT2A receptor occupancy of different doses of quetiapine in schizophrenia: a PET study

Clozapine for the Treatment-Resistant Schizophrenic

1988 • 4,030 citations

Graphical Evaluation of Blood-to-Brain Transfer Constants from Multiple-Time Uptake Data

1983 • 3,439 citations

Simplified Reference Tissue Model for PET Receptor Studies

1996 • 1,980 citations

Graphical Evaluation of Blood-to-Brain Transfer Constants from Multiple-Time Uptake Data. Generalizations

1985 • 1,604 citations

Distribution Volume Ratios without Blood Sampling from Graphical Analysis of PET Data

1996 • 1,461 citations

Multiple fixed doses of “Seroquel” (quetiapine) in patients with acute exacerbation of schizophrenia: A comparison with haloperidol and placebo

1997 • 756 citations

Clinical and Theoretical Implications of 5-HT₂ and D₂ Receptor Occupancy of Clozapine, Risperidone, and Olanzapine in Schizophrenia

1999 • 706 citations

Quetiapine in Patients With Schizophrenia

1997 • 487 citations

Kinetic Analysis of Central [¹¹C]Raclopride Binding to D₂-Dopamine Receptors Studied by PET—A Comparison to the Equilibrium Analysis

1989 • 454 citations

A Positron Emission Tomography Study of Quetiapine in Schizophrenia: A Preliminary Finding of an Antipsychotic Effect With Only Transiently High Dopamine D2 Receptor Occupancy

2000 • 401 citations

5-HT₂ and D₂ Receptor Occupancy of Olanzapine in Schizophrenia: A PET Investigation

1998 • 364 citations

Clinical and Biologic Response to Clozapine in Patients With Schizophrenia

1992 • 356 citations

The ratios of serotonin2 and dopamine2 affinities differentiate atypical and typical antipsychotic drugs.

1989 • 321 citations

Antipsychotic drugs which elicit little or no Parkinsonism bind more loosely than dopamine to brain D2 receptors, yet occupy high levels of these receptors

1998 • 293 citations

ICI 204,636, an Atypical Antipsychotic

1996 • 275 citations

A comparison of quetiapine and chlorpromazine in the treatment of schizophrenia

1997 • 253 citations

Suggested Minimal Effective Dose of Risperidone Based on PET-Measured D₂ and 5-HT_2A Receptor Occupancy in Schizophrenic Patients

1999 • 243 citations

Rapid Release of Antipsychotic Drugs From Dopamine D₂ Receptors: An Explanation for Low Receptor Occupancy and Early Clinical Relapse Upon Withdrawal of Clozapine or Quetiapine

1999 • 241 citations

5-HT2 and D2 dopamine receptor occupancy in the living human brain

1993 • 228 citations

Time course of central nervous dopamine-D 2 and 5-HT 2 receptor blockade and plasma drug concentrations after discontinuation of quetiapine (Seroquel ® ) in patients with schizophrenia

1998 • 167 citations

Time course of D2-dopamine receptor occupancy examined by PET after single oral doses of haloperidol

1992 • 160 citations

The Importance of Serotonin-Dopamine Interactions in the Action of Clozapine

1992 • 137 citations

A rapid and accurate method to realign PET scans utilizing image edge information.

1995 • 105 citations

Dose dependent occupancy of central dopamine D2 receptors by the novel neuroleptic CP-88,059-01: a study using positron emission tomography and11C-raclopride

1993 • 98 citations

Supersensitivity psychosis in schizophrenic patients after sudden clozapine withdrawal

1984 • 89 citations

Analysis and pharmacokinetics of quetiapine and two metabolites in human plasma using reversed-phase HPLC with ultraviolet and electrochemical detection

1999 • 69 citations

Risperidone and olanzapine

1998 • 54 citations

Delayed Normalization of Central D2 Dopamine Receptor Availability After Discontinuation of Haloperidol Decanoate

1997 • 50 citations

Receptor binding of N-(methyl-11C) clozapine in the brain of rhesus monkey studied by positron emission tomography (PET)

1986 • 38 citations

N-[11C]Methylspiperone PET, in contrast to [11C]raclopride, fails to detect D2 receptor occupancy by an atypical neuroleptic

1998 • 32 citations

Receptor binding and selectivity of three 11C-labelled dopamine receptor antagonists in the brain of Rhesus monkeys studied with positron emission tomography

1988 • 21 citations