RT Loop Flexibility Enhances the Specificity of Src Family SH3 Domains for HIV-1 Nef^,

PROCHECK: a program to check the stereochemical quality of protein structures

1993 • 23,689 citations

AMoRe: an automated package for molecular replacement

1994 • 4,990 citations

Automatic processing of rotation diffraction data from crystals of initially unknown symmetry and cell constants

1993 • 3,564 citations

AMBER, a package of computer programs for applying molecular mechanics, normal mode analysis, molecular dynamics and free energy calculations to simulate the structural and energetic properties of molecules

1995 • 3,001 citations

Rapid measurement of binding constants and heats of binding using a new titration calorimeter

1989 • 2,603 citations

Proline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for down-regulation of CD4.

1995 • 557 citations

A New Approach to the Rapid Determination of Protein Side Chain Conformations

1991 • 345 citations

Identification of Src, Fyn, Lyn, PI3K and Abl SH3 domain ligands using phage display libraries.

1994 • 256 citations

Crystal structure of the SH3 domain in human Fyn; comparison of the three-dimensional structures of SH3 domains in tyrosine kinases and spectrin.

1993 • 208 citations

Separable functions of Nef disrupt two aspects of T cell receptor machinery: CD4 expression and CD3 signaling

1997 • 206 citations

SH3-mediated Hck Tyrosine Kinase Activation and Fibroblast Transformation by the Nef Protein of HIV-1

1997 • 201 citations

Crystal structure of the SH3 domain in human Fyn; comparison of the three-dimensional structures of SH3 domains in tyrosine kinases and spectrin.

1993 • 194 citations

Identification and characterization of Src SH3 ligands from phage-displayed random peptide libraries.

1994 • 166 citations

Mutational analysis of the Src SH3 domain: the same residues of the ligand binding surface are important for intra- and intermolecular interactions.

1995 • 163 citations

Human immunodeficiency virus type 1 Nef binds directly to Lck and mitogen-activated protein kinase, inhibiting kinase activity

1996 • 134 citations