Alcohol Abuse, Alcoholism, and Damage to the Immune System—A Review
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Abstract
References (172)
Innate immunity: impact on the adaptive immune response
1997 • 1,542 citations
A cell-surface molecule involved in organ-specific homing of lymphocytes
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Glutathione levels in antigen-presenting cells modulate Th1 versus Th2 response patterns
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Alcohol and the liver: 1994 update
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Increased Plasma Tumor Necrosis Factor in Severe Alcoholic Hepatitis
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Ethanol metabolism, cirrhosis and alcoholism
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Biology of human TH1 and TH2 cells
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Protein-calorie malnutrition associated with alcoholic hepatitis
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Reported tuberculosis in the United States 2013
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Plasma Tumor Necrosis Factor α Predicts Decreased Long‐Term Survival in Severe Alcoholic Hepatitis
1990 • 305 citations
Cytokines and Alcoholic Liver Disease
1993 • 292 citations
Modulation of macrophage functioning abrogates the acute hepatotoxicity of acetaminophen
1995 • 281 citations
Monoclonal and polyclonal antibodies against acetaldehyde-containing epitopes in acetaldehyde-protein adducts.
1986 • 263 citations
Increased plasma interleukin-8 concentrations in alcoholic hepatitis
1993 • 248 citations
Acetaldehyde and malondialdehyde react together to generate distinct protein adducts in the liver during long-term ethanol administration
1996 • 243 citations
Regulation of Human Monocyte Functions by Acute Ethanol Treatment: Decreased Tumor Necrosis Factorα, Interleukin‐lβ and Elevated Interleukin‐10, and Transforming Growth Factor‐β Production
1996 • 232 citations
Alcoholic Liver Disease: Pathologic, Pathogenetic and Clinical Aspects
1991 • 224 citations
Relationship of Protein Calorie Malnutrition to Alcoholic Liver Disease: A Reexamination of Data from Two Veterans Administration Cooperative Studies
1995 • 208 citations
Cytokine gene expression by Kupffer cells in experimental alcoholic liver disease
1995 • 201 citations
Chronic alcohol intoxication induces hepatic injury through enhanced macrophage inflammatory protein-2 production and intercellular adhesion molecule-1 expression in the liver
1997 • 177 citations
Ethanol and signal transduction in the liver.
1992 • 157 citations
High Incidence Rates of Invasive Pneumococcal Disease in the White Mountain Apache Population
1992 • 157 citations
Covalent Binding of Acetaldehyde to Proteins: Participation of Lysine Residues
1987 • 155 citations
Granulocyte Colony-Stimulating Factor Enhances Pulmonary Host Defenses in Normal and Ethanol-Treated Rats
1991 • 150 citations
Ethanol and signal transduction in the liver
1992 • 138 citations
Serum levels of interleukin-8 in alcoholic liver disease: relationship with disease stage, biochemical parameters and survival
1996 • 128 citations
Tuberculosis, AIDS, and Death among Substance Abusers on Welfare in New York City
1996 • 116 citations
Detection of antibodies against proteins modified by hydroxyethyl free radicals in patients with alcoholic cirrhosis
1995 • 116 citations
Effect of acute alcohol intoxication on granulocyte mobilization and kinetics
1978 • 115 citations
Bacteremia in patients with cirrhosis of the liver
1991 • 114 citations
Cytochrome P4502E1 hydroxyethyl radical adducts as the major antigen in autoantibody formation among alcoholics
1996 • 113 citations
Down-regulation of tumor necrosis factor ? activity by acute ethanol treatment in human peripheral blood monocytes
1993 • 113 citations
Nitric oxide production in experimental alcoholic liver disease in the rat: Role in protection from injury
1995 • 112 citations
An Animal Model of Mycobacterium avium Complex Disseminated Infection after Colonization of the Intestinal Tract
1992 • 108 citations
Community-Acquired Bacteremic Pneumococcal Pneumonia
1984 • 107 citations
Alcohol Intake Increases Human Immunodeficiency Virus Type 1 Replication in Human Peripheral Blood Mononuclear Cells
1993 • 106 citations
ROLE OF MACROPHAGES IN ACETAMINOPHEN (PARACETAMOL)-INDUCED HEPATOTOXICITY
1996 • 103 citations
Effect of Ethanol on Functions Required for the Delivery of Neutrophils to Sites of Inflammation
1988 • 98 citations
Alcoholism is associated with hepatitis C but not hepatitis B in an urban population.
1996 • 98 citations
Serum IgA, IgG, and IgM antibodies directed against acetaldehyde-derived epitopes: Relationship to liver disease severity and alcohol consumption
1997 • 96 citations
HUMAN MONOCYTE IL-10 PRODUCTION IS INCREASED BY ACUTE ETHANOL TREATMENT
1996 • 94 citations
Tuberculosis Screening in Alcoholics and Drug Addicts
1987 • 94 citations
INFLUENCE OF ALCOHOL ON PROGNOSIS OF PNEUMONIA IN COOK COUNTY HOSPITAL
1923 • 92 citations
Selective inhibition of antigen-specific T lymphocyte proliferation by acute ethanol exposure: the role of impaired monocyte antigen presentation capacity and mediator production
1993 • 92 citations
Identification of Alcohol Abuse and Alcoholism with Biological Parameters
1986 • 91 citations
Plasma membrane hydroxyethyl radical adducts cause antibody-dependent cytotoxicity in rat hepatocytes exposed to alcohol
1997 • 89 citations
Humoral immune response to acetaldehyde adducts in alcoholic patients.
1986 • 87 citations
Ethanol‐Induced Apoptosis and Oxidative Stress in Hepatocytes
1996 • 87 citations
Ethanol Feeding Impairs Innate Immunity and Alters the Expression of Th1‐ and Th2‐Phenotype Cytokines in Murine Klebsiella Pneumonia
1998 • 86 citations
Increased Human Immunodeficiency Virus Type 1 Replication in Human Peripheral Blood Mononuclear Cells Induced by Ethanol: Potential Immunopathogenic Mechanisms
1996 • 85 citations
Role of Granulocyte Colony-Stimulating Factor in the Immune Response to Acute Bacterial Infection in the Nonneutropenic Host: An Overview
1994 • 80 citations
Immunologic Reactions in Alcoholic Liver Disease
1993 • 78 citations
Ethanol Increases Apoptotic Cell Death of Thymocytes in Vitro
1993 • 78 citations
Loss of the CD5+ and CD45RAhi B cell subsets in alcoholics
1996 • 77 citations
Alcohol Modulates Alveolar Macrophage Tumor Necrosis Factor‐α, Superoxide Anion, and Nitric Oxide Secretion in the Rat
1996 • 77 citations
Altered expression of monocyte IgA Fc receptors is associated with defective endocytosis in patients with alcoholic cirrhosis. Potential role for IFN-gamma.
1995 • 75 citations
Deficient natural killer cell activity in alcoholic cirrhosis.
1984 • 75 citations
Alcohol‐Induced Regulation of Nuclear Regulatory Factor‐Kβ in Human Monocytes
1997 • 75 citations
Acetaldehyde adducts and autoantibodies against VLDL and LDL in alcoholics
1993 • 70 citations
Ethanol Feeding Inhibits Proinflammatory Cytokine Expression from Murine Alveolar Macrophages Ex Vivo
1997 • 69 citations
Alcohol and Cytokine‐inducible Transcription Factors
1996 • 68 citations
Modulation of T‐Cell Adhesion Markers, and the CD45R and CD57 Antigens in Human Alcoholics
1995 • 67 citations
Autoantibodies in alcoholic liver disease
1990 • 66 citations
LOBAR PNEUMONIA AND ALCOHOLISM
1967 • 66 citations
Impairment of Polymorphonuclear Leukocyte Immigration as a Mechanism of Alcohol-induced Suppression of Pulmonary Antibacterial Defenses1–3
1983 • 66 citations
Pneumococcal bacteraemia during a recent decade
1992 • 64 citations
Ethanol Causes Accelerated G1 Arrest in Differentiating HL‐60 Cells
1990 • 62 citations
Human Neutrophil Functions Are Inhibited In Vitro by Clinically Relevant Ethanol Concentrations
1996 • 62 citations
Effects of Ethanol on Cellular Immunity to Facultative Intracellular Bacteria
1995 • 62 citations
Effects of Alcohol Ingestion on in Vitro Susceptibility of Peripheral Blood Mononuclear Cells to Infection with HIV and of Selected T‐Cell Functions
1989 • 60 citations
Differential Regulation of Manganese Superoxide Dismutase Activity by Alcohol and TNF in Human Hepatoma Cells
1995 • 59 citations
Acute Ethanol Intoxication Suppresses the Pulmonary Inflammatory Response in Rats Challenged with Intrapulmonary Endotoxin
1997 • 59 citations
Inhibition of the Kupffer Cell Inflammatory Response by Acute Ethanol: NF-κB Activation and Subsequent Cytokine Production
1996 • 59 citations
Rat hepatocytes and Kupffer cells interact to produce interleukin-8 (CINC) in the setting of ethanol
1995 • 57 citations
Ethanol and Natural Killer Cells. I. Activity and Immunophenotype in Alcoholic Humans
1997 • 55 citations
Acute Ethanol Intoxication Inhibits Neutrophil β2‐Integrin Expression in Rats During Endotoxemia
1998 • 54 citations
Ethanol decreases the number and activity of splenic natural killer cells in a mouse model for binge drinking.
1994 • 53 citations
Liver membrane antibodies in alcoholic liver disease. II. Antibodies to ethanol-altered hepatocytes.
1983 • 53 citations
Ethanol metabolism in the generation of new antigenic determinants on liver cells.
1986 • 53 citations
Alveolar Macrophage Release of Tumor Necrosis Factor‐α in Chronic Alcoholics without Liver Disease
1998 • 53 citations
Immune Responses in Alcoholic Liver Disease
1986 • 53 citations
Alterations in Tumor Necrosis Factor‐α, Interferon‐γ, and Interleukin‐6 Production by Natural Killer Cell‐Enriched Peripheral Blood Mononuclear Cells in Chronic Alcoholism: Relationship with Liver Disease and Ethanol Intake
1997 • 52 citations
Alcohol, Tumor Necrosis Factor, and Tuberculosis
1995 • 52 citations
T Lymphocyte Populations in Fetal Alcohol Syndrome
1989 • 51 citations
Immune Function in Alcoholism: A Controlled Study
1993 • 50 citations
Fine T‐Cell Subsets in Alcoholics as Determined by the Expression of <scp>l</scp>‐Selectin, Leukocyte Common Antigen, and β‐Integrin
1994 • 49 citations
Ethanol increases tumor progression in rats: Possible involvement of natural killer cells
1992 • 49 citations
Ethanol feeding enhances inflammatory cytokine expression in lipopolysaccharide‐induced hepatitis
1997 • 49 citations
Biphasic in vivo immune function after low- versus high-dose alcohol consumption
1997 • 47 citations
Ethanol‐Induced Adaptation in Biological Membranesa
1987 • 47 citations
Induction of transforming growth factor-beta and prostaglandin E2 production by ethanol in human monocytes
1992 • 47 citations
Ethanol impairs the induction of delayed hypersensitivity in C57BL/6 mice
1997 • 46 citations
Immunological Aspects
1993 • 46 citations
Regulation of Monocyte Interleukin‐12 Production by Acute Alcohol: A Role for Inhibition by Interleukin‐10
1998 • 45 citations
Ethanol modulates epidermal growth factor-stimulated tyrosine kinase and phosphorylation of PLC-γ1
1992 • 45 citations
Ethanol Ingestion Impairs Neutrophil Bactericidal Mechanisms against Streptococcus pneumoniae
1996 • 45 citations
Alcohol Use and T‐Lymphocyte Subsets among Injection Drug Users with HIV‐1 Infection: A Prospective Analysis
1996 • 44 citations
Intercellular Adhesion Molecule-1 Expression in Experimental Alcoholic Liver Disease: Relationship to Endotoxemia and TNFα Messenger RNA
1995 • 43 citations
Adenoviral‐Mediated Interferon‐γ Gene Therapy Augments Pulmonary Host Defense of Ethanol‐Treated Rats
1998 • 43 citations
ALCOHOL AND ENDOTOXIN: ANOTHER PATH TO ALCOHOLIC LIVER INJURY?
1995 • 43 citations
Interleukin‐12 Therapy Restores Cell‐Mediated Immunity in Ethanol‐Consuming Mice
1998 • 43 citations
Chronic Alcohol Intoxication Enhances the Expression of CD18 Adhesion Molecules on Rat Neutrophils and Release of a Chemotactic Factor by Kupffer Cells
1995 • 43 citations
Decreased Tumor Necrosis Factor‐α and Interleukin‐1α Production from Intrahepatic Mononuclear Cells in Chronic Ethanol Consumption and Upregulation by Endotoxin
1998 • 41 citations
Granulocyte Colony-Stimulating Factor Protects Control Rats but Not Ethanol-Fed Rats from Fatal Pneumococcal Pneumonia
1993 • 40 citations
Ethanol Ingestion Inhibits Cell‐Mediated Immune Responses of Unprimed T‐Cell Receptor Transgenic Mice
1996 • 39 citations
T-cell activation, expression of adhesion molecules and response to ethanol in alcoholic cirrhosis
1996 • 39 citations
Alcohol, cancer, and immunomodulation
1989 • 38 citations
Effect of a single ethanol exposure on HIV replication in human lymphocytes.
1997 • 38 citations
Structure-Functional Effects of a Series of Alcohols on Acetylcholinesterase-Associated Membrane-Vesicles - Elucidation of Factors Contributing to the Alcohol Action
1995 • 38 citations
Ethanol and Hepatocellular Injury
1996 • 37 citations
Alcohol Decreases T‐Lymphocyte Migration into Lung Tissue in Response to Pneumocystis carinii and Depletes T‐Lymphocyte Numbers in the Spleens of Mice
1998 • 37 citations
Nitric Oxide and Liver Injury in Alcohol‐Fed Rats after Lipopolysaccharide Administration
1996 • 36 citations
Long lasting immunological effects of ethanol after withdrawal
1996 • 36 citations
Effects of Ethanol Consumption on Enriched Natural Killer Cells from C57BL/6 Mice
1994 • 36 citations
Adult bacteremic pneumonia: bacteriology and prognostic factors.
1992 • 35 citations
Impaired antigen presention by splenocytes of ethanol-consuming C57BL/6 mice
1995 • 35 citations
Relationship Between Alcohol Intake and Immunoglobulin A Immunoreactivity with Acetaldehyde‐Modified Bovine Serum Albumin
1996 • 35 citations
Effects of Ethanol on the Chemotactic Peptide-Induced Second Messenger Generation and Superoxide Production in Polymorphonuclear Leukocytes
1992 • 34 citations
Ethanol Impairs Neutrophil Chemotaxis In Vitro but Not Adherence or Recruitment to Lungs of Rats with Experimental Pneumococcal Pneumonia
1993 • 34 citations
Influence of Ethanol Consumption on Immune Competence of Adult Animals Exposed to Ethanol In Utero
1998 • 34 citations
Abnormality in Membrane Fatty Acid Compositions of Cells Measured on Erythrocyte in Alcoholic Liver Disease
1996 • 31 citations
Increased susceptibility of experimental animals to infectious organisms as a consequence of ethanol consumption.
1994 • 31 citations
Ethanol Modulates Metastatic Potential of B16BL6 Melanoma and Host Responses
1996 • 30 citations
Alcohol consumption suppresses metastasis of B16-BL6 melanoma in mice
1993 • 29 citations
Abnormalities of Peripheral Blood T Lymphocytes and Natural Killer Cells in Alcoholic Hepatitis Persist after a 3‐Month Withdrawal Period
1997 • 28 citations
Interaction of ethanol with inducible nitric oxide synthase messenger RNA and protein: direct effects on autacoids and endotoxin in vivo.
1997 • 28 citations
Interleukin-8 in alcoholic liver disease.
1994 • 28 citations
Recent studies on the effects of fetal alcohol exposure on the endocrine and immune systems.
1994 • 27 citations
MODULATION OF THE LUNG HOST RESPONSE BY GRANULOCYTE COLONY-STIMULATING FACTOR IN RATS CHALLENGED WITH INTRAPULMONARY ENDOTOXIN
1997 • 27 citations
Altered T‐Lymphocyte Responsiveness to Polyclonal Cell Activators Is Responsible for Liver Cell Necrosis in Alcohol‐fed Rats
1998 • 27 citations
Effect of chronic alcohol consumption by rats on tumor necrosis factor-α and interleukin-6 clearance in vivo and by the isolated, perfused liver
1996 • 24 citations
Detection of Reduced Acetaldehyde Protein Adducts Using a Unique Monoclonal Antibody
1994 • 24 citations
Fatty acid ethyl ester synthesis by the isolated perfused rat heart
1997 • 24 citations
Ethanol Consumption Suppresses Cell‐Mediated Inflammatory Responses and Increases T‐Helper Type 2 Cytokine Secretion in Trichinella spiralis‐Infected Rats
1997 • 24 citations
In vitro effects of ethanol on the phagocytic and microbial killing activities of normal human blood monocytes and monocyte-derived macrophages
2008 • 23 citations
The Influence of Age on Blood Alcohol Levels and Ethanol‐Associated Immunosuppression in a Murine Model of Ethanol Consumption
1993 • 23 citations
A brief review of immunomodulation caused by acute administration of ethanol: involvement of neuroendocrine pathways.
1994 • 23 citations
Tuberculosis mortality associated with AIDS and drug or alcohol abuse: analysis of multiple cause-of-death data
1996 • 23 citations
Ethanol Suppresses Mycobacteria tuberculosis‐Induced mRNA for Nitric Oxide Synthase in Alveolar Macrophages, In Vivo
1995 • 23 citations
Inhibitory Effect of Ethanol on Hepatocyte Growth Factor‐Induced DNA Synthesis and Ca2+ Mobilization in Rat Hepatocytes
1996 • 22 citations
Effects of Granulocyte Colony-Stimulating Factor in Cirrhotic Rats with Pneumococcal Pneumonia
1996 • 22 citations
THE EFFECT OF ETHANOL INGESTION ON KILLING OF <italic>STREPTOCOCCUS PNEUMONIAE, STAPHYLOCOCCUS AUREUS</italic> AND <italic>STAPHYLOCOCCUS EPIDERMIDIS</italic> BY RAT NEUTROPHILS
1995 • 22 citations
Effect of ethanol on the interaction between the macrophage and Mycobacterium avium
1994 • 21 citations
Binding of Anti‐Acetaldehyde IgG Antibodies to Hepatocytes with an Acetaldehyde‐Phosphatidylethanolamine Adduct on Their Surface
1991 • 21 citations
Effect of short-term ethanol treatment on voltage-dependent calcium channels in kupffer cells
1993 • 20 citations
Expression of Tumor Necrosis Factor‐α and Interleukin‐6 Cell‐Surface Receptors of the Alveolar Macrophage in Alcohol‐Treated Rats
1994 • 20 citations
Ethanol, Immune Reactions and the Digestive System
1981 • 20 citations
THE ROLE OF HEPATITIS C VIRUS IN ALCOHOLIC LIVER DISEASE
1997 • 19 citations
Ethanol Ingestion Reduces Antipneumococcal Activity of Rat Pulmonary Surfactant
1996 • 19 citations
Effects of Chronic Ethanol Administration on the Endocytosis of Cytokines by Rat Hepatocytes
1996 • 18 citations
Alcohol‐Induced Liver Disease
1985 • 17 citations
Specificity to N-ethyl lysine of a monoclonal antibody to acetaldehyde-modified proteins prepared under reducing conditions
1994 • 16 citations
Chronic Alcohol Intoxication Attenuates Human Immunodeficiency Virus‐1 Glycoprotein 120‐Induced Superoxide Anion Release by Isolated Kupffer Cells
1998 • 15 citations
Alcoholic liver damage-toxicity, autoimmunity and allergy
1994 • 15 citations
Acute Ethanol Treatment Augments Interleukin‐12 Production in Activated Human Monocytes
1996 • 15 citations
Ethanol and Natural Killer Cells. II. Stimulation of Human Natural Killer Activity by Ethanol In Vitro
1997 • 15 citations
Alcohol, drugs of abuse, and immune functions
1995 • 15 citations
Effect of Chronic Ethanol Feeding on Endotoxin‐Induced Hepatic Injury: Role of Adhesion Molecules on Leukocytes and Hepatic Sinusoid
1998 • 13 citations
Effects of Recombinant Human Insulin‐like Growth Factor‐1 and Recombinant Human Growth Hormone on Anabolism and Immunity in Calorie‐Restricted Alcoholic Rats
1997 • 12 citations
Impaired Secretion And Mrna Expression Of Monokines By Alveolar Macrophages From Nonsmoking Patients With Alcoholic Liver Cirrhosis
1995 • 11 citations
Acute ethanol intoxication can inhibit leucocyte mobilization in the corneal wounds
1981 • 9 citations
Activated Lymphocytes (CD25 CD69 Cells) and Decreased CD19 Cells in Well-Nourished Chronic Alcoholics without Ethanol-Related Diseases
1998 • 8 citations
Circulating Neutrophils and Liver Injury in Rat Models of Experimental Alcoholic Liver Disease
1998 • 8 citations
Circulating neutrophils and liver injury in rat models of experimental alcoholic liver disease.
1998 • 8 citations
Granulocyte Colony Stimulating Factor in the Treatment of Alcohol Abuse, Leukopenia, and Pneumococcal Sepsis
1995 • 8 citations
Chronic Ethanol Exposure Alters Leukocyte Subsets in Repopulating Spleens, But Does Not Alter Negative Selection in Thymuses of Sublethally Irradiated Mice
1997 • 7 citations
Pathogenesis of IgA nephropathy in ethanol consumption: Animal model and cell culture studies
1993 • 7 citations
Ethanol Increases K+ Conductance in Human T‐Cells
1993 • 4 citations