Effect of chronic alcohol consumption by rats on tumor necrosis factor-α and interleukin-6 clearance in vivo and by the isolated, perfused liver

An endotoxin-induced serum factor that causes necrosis of tumors.

1975 • 4,522 citations

Interleukin-6 and the acute phase response

1990 • 2,740 citations

Interleukin-6 in Biology and Medicine

1993 • 1,398 citations

Cachectin/tumor necrosis factor: production, distribution, and metabolic fate in vivo.

1985 • 788 citations

Cells of the hepatic sinusoid

1989 • 589 citations

Increased tumor necrosis factor production by monocytes in alcoholic hepatitis

1989 • 542 citations

Alcohol and Immune Defense

1986 • 427 citations

Antitumor activity of murine tumor necrosis factor (TNF) against transplanted murine tumors and heterotransplanted human tumors in nude mice

1984 • 313 citations

Plasma clearance, organ distribution and target cells of interleukin‐6/hepatocyte‐stimulating factor in the rat

1988 • 298 citations

Cytokines and Alcoholic Liver Disease

1993 • 292 citations

Effect of tumour necrosis factor on cultured human melanoma cells

1975 • 240 citations

Genes coding for RNA polymerase β subunit in bacteria

1988 • 225 citations

Human tumor xenografts treated with recombinant human tumor necrosis factor alone or in combination with interferons.

1986 • 211 citations

High interleukin-6 serum levels and increased production by leucocytes in alcoholic liver cirrhosis. Correlation with IgA serum levels and lymphokines production.

1989 • 185 citations

Influence of Ethanol Consumption on Natural Killer Cell Activity in Mice

1989 • 117 citations

Acute Alcohol Infusion Suppresses Endotoxin‐induced Serum Tumor Necrosis Factor

1989 • 117 citations

Biochemical and Ultrastructural Evaluation of Isolated Rat Liver Systems Perfused with a Hemoglobin-Free Medium

1978 • 117 citations

Hyaluronic acid uptake by the isolated, perfused rat liver: An index of hepatic sinusoidal endothelial cell function

1993 • 97 citations

Continuous internalization of tumor necrosis factor receptors in a human myosarcoma cell line.

1988 • 97 citations

Phase I study of recombinant human tumor necrosis factor ? in advanced malignant disease

1989 • 96 citations

Hematological Complications of Alcoholism

1989 • 88 citations

Alcohol Modulates Alveolar Macrophage Tumor Necrosis Factor‐α, Superoxide Anion, and Nitric Oxide Secretion in the Rat

1996 • 77 citations

Kinetics of epidermal growth factor binding and processing in isolated intact rat hepatocytes

1987 • 58 citations

Cellular targets and receptors for interleukin‐6 I. In vivo and in vitro uptake of IL‐6 in liver and hepatocytes

1990 • 54 citations

Ethanol affects release of TNF and GM-CSF and membrane expression of TNF receptors by human macrophages.

1991 • 53 citations

Pharmacokinetics and tissue distribution of recombinant human tumor necrosis factor-alpha in mice.

1988 • 51 citations

Binding, Internalization, and Intracellular Processing of Proteins Interacting with Recycling Receptors

1989 • 48 citations

Tumor Necrosis Factor‐α Cell‐Surface Receptors of Liver Parenchymal and Nonparenchymal Cells during Acute and Chronic Alcohol Administration to Rats

1995 • 41 citations

Suppression of Tumor Necrosis Factor Production by Alcohol in Lipopolysaccharide‐Stimulated Culture

1994 • 36 citations

Prenatal Alcohol Exposure Alters the Hypothalamic‐Pituitary‐Adrenal Axis Response of Immature Offspring to Interleukin‐1: Is Nitric Oxide Involved?

1994 • 30 citations

Studies on tumor necrosis factor (TNF): II. Metabolic fate and distribution of human recombinant TNF.

1987 • 30 citations

Alcohol Modulation of Immune Function: Clinical and Experimental Data

1995 • 27 citations

Alcohol Consumption in Rats Potentiates the Deleterious Effect of Gram‐Negative Sepsis on Hepatic Hyaluronan Uptake

1993 • 22 citations

Effect of Maternal Ethanol Consumption on in Vitro Tumor Necrosis Factor, Interleukin-6 and Interleukin-2 Production by Rat Milk and Blood Leukocytes

1994 • 22 citations

Interleukin‐6 and Tumor Necrosis Factor‐α Clearance and Metabolism In Vivo and by the Isolated, Perfused Liver in the Rat: Effect of Acute Alcohol Administration

1996 • 21 citations

Expression of Tumor Necrosis Factor‐α and Interleukin‐6 Cell‐Surface Receptors of the Alveolar Macrophage in Alcohol‐Treated Rats

1994 • 20 citations

Pharmacokinetics of recombinant human tumor necrosis factor-alpha in rats. Effects of size and number of doses and nephrectomy.

1989 • 19 citations

Liver Sinusoid during Chronic Alcohol Consumption in the Rat: An Electron Microscopic Study

1995 • 18 citations

Ethanol Consumption Reduces the Cytolytic Activity of Lymphokine‐Activated Killer Cells

1995 • 17 citations

Plasma disappearance and organ distribution of recombinant human tumor necrosis factor-alpha in rats.

1991 • 14 citations

Effect of Acute and Chronic Alcohol Administration to Rats on the Expression of Interleukin‐6 Cell‐Surface Receptors of Hepatic Parenchymal and Nonparenchymal Cells

1994 • 14 citations

Moving Developmental Research into the Clinic

1994 • 5 citations