Regulation of Monocyte Interleukin‐12 Production by Acute Alcohol: A Role for Inhibition by Interleukin‐10

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

1986 • 7,504 citations

Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes.

1991 • 3,812 citations

Development of T _H 1 CD4 ⁺ T Cells Through IL-12 Produced by Listeria -Induced Macrophages

1993 • 3,140 citations

Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression.

1991 • 1,950 citations

Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells.

1993 • 1,409 citations

A TH1→TH2 switch is a critical step in the etiology of HIV infection

1993 • 1,403 citations

Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells.

1992 • 1,168 citations

Interleukin-12 and its role in the generation of TH1 cells

1993 • 869 citations

Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor.

1991 • 593 citations

Activated T cells induce interleukin‐12 production by monocytes via CD40‐CD40 ligand interaction

1995 • 427 citations

Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activity.

1995 • 407 citations

Regulation of interleukin-12 expression in human monocytes: selective priming by interferon-gamma of lipopolysaccharide-inducible p35 and p40 genes

1995 • 341 citations

Roles of IFN-gamma and IFN-alpha in IL-12-induced T helper cell-1 development.

1996 • 313 citations

Regulation of bioactive IL-12 production in lipopolysaccharide-stimulated human monocytes is determined by the expression of the p35 subunit.

1996 • 306 citations

A direct role for IFN-gamma in regulation of Th1 cell development.

1996 • 304 citations

Immunoregulation by interleukin-12

1996 • 298 citations

Stimulation of hepatic lipocyte collagen production by Kupffer cell-derived transforming growth factor β: Implication for a pathogenetic role in alcoholic liver fibrogenesis

1990 • 295 citations

Interferon gamma inhibits interleukin 10 production by monocytes.

1993 • 294 citations

TGF-beta contributes to the shift toward Th2-type responses through direct and IL-10-mediated pathways in tumor-bearing mice.

1996 • 274 citations

The Effects of Acute and Chronic Alcoholism on Tumor Necrosis Factor and the Inflammatory Response

1989 • 239 citations

Regulation of Human Monocyte Functions by Acute Ethanol Treatment: Decreased Tumor Necrosis Factorα, Interleukin‐lβ and Elevated Interleukin‐10, and Transforming Growth Factor‐β Production

1996 • 232 citations

IL-12-induced IL-10 production by human T cells as a negative feedback for IL-12-induced immune responses.

1996 • 208 citations

TGF-beta enhances macrophage ability to produce IL-10 in normal and tumor-bearing mice.

1995 • 170 citations

Inhibition of superantigen-induced T cell proliferation and monocyte IL-1β, TNF-α, and IL-6 production by acute ethanol treatment

1995 • 124 citations

IL-12 induces human T cells secreting IL-10 with IFN-gamma.

1996 • 121 citations

Down-regulation of tumor necrosis factor ? activity by acute ethanol treatment in human peripheral blood monocytes

1993 • 113 citations

HUMAN MONOCYTE IL-10 PRODUCTION IS INCREASED BY ACUTE ETHANOL TREATMENT

1996 • 94 citations

Selective inhibition of antigen-specific T lymphocyte proliferation by acute ethanol exposure: the role of impaired monocyte antigen presentation capacity and mediator production

1993 • 92 citations

Biological function and distribution of human interleukin‐12 receptor β chain

1996 • 83 citations

Ethanol Augments Intracellular Survival of Mycobacterium avium Complex and Impairs Macrophage Responses to Cytokines

1991 • 75 citations

Ethanol‐Induced Suppression of Cell‐Mediated Immunity in the Mouse

1992 • 69 citations

Ethanol Ingestion Increases Susceptibility of Mice to Listeria monocytogenes

1993 • 65 citations

Bacterial superantigen-induced human lymphocyte responses are nitric oxide dependent and mediated by IL-12 and IFN-gamma.

1996 • 59 citations

IgA triggers tumor necrosis factor α secretion by monocytes: A study in normal subjects and patients with alcoholic cirrhosis

1991 • 54 citations

Ethanol affects release of TNF and GM-CSF and membrane expression of TNF receptors by human macrophages.

1991 • 53 citations

Induction of transforming growth factor-beta and prostaglandin E2 production by ethanol in human monocytes

1992 • 47 citations

Alterations in Interleukin‐2 Utilization by T‐Cells from Rats Treated with an Ethanol‐Containing Diet

1990 • 37 citations

Diagnosis of Alcohol Abuse

1989 • 36 citations

Ethanol modulation of tumor necrosis factor and gamma interferon production by murine splenocytes and macrophages

1993 • 29 citations

Low serum levels of ?-interferon, ?-interferon, and interleukin-2 in alcoholic cirrhosis

1991 • 28 citations

In vivo augmentation of IFN-γ with a rIL-12 human/mouse chimera: Pleiotropic effects against infectious agents in mice and rats

1994 • 15 citations