Organization, Transcription, and Regulation in the Animal Genome

Repeated Sequences in DNA

1968 • 2,836 citations

Gene Regulation for Higher Cells: A Theory

1969 • 2,022 citations

Chromosomal Localization of Mouse Satellite DNA

1970 • 1,119 citations

Purification and Further Properties of Single‐Strand‐Specific Nuclease from Aspergillus oryzae

1973 • 862 citations

Repetitive and Non-Repetitive DNA Sequences and a Speculation on the Origins of Evolutionary Novelty

1971 • 797 citations

Localization and kinetics of formation of nuclear heterodisperse RNA, cytoplasmic heterodisperse RNA and polyribosome-associated messenger RNA in HeLa cells

1968 • 572 citations

Polyadenylic Acid Sequences: Role in Conversion of Nuclear RNA into Messenger RNA

1971 • 569 citations

Polyadenylic Acid Sequences in the Heterogeneous Nuclear RNA and Rapidly-Labeled Polyribosomal RNA of HeLa Cells: Possible Evidence for a Precursor Relationship

1971 • 503 citations

Small molecular weight monodisperse nuclear RNA

1968 • 500 citations

Regulation of protein synthesis in mammalian cells

1970 • 474 citations

Chromosomal and Nuclear Location of Mouse Satellite DNA in Individual Cells

1970 • 470 citations

A nuclease specific for heat-denatured DNA isolated from a product of Aspergillus oryzae

1966 • 457 citations

A comparison of the ribosomal DNA's of Xenopus laevis and Xenopus mulleri: the evolution of tandem genes

1972 • 428 citations

A crude nuclease preparation suitable for use in DNA reassociation experiments

1971 • 428 citations

General Model for the Chromosomes of Higher Organisms

1971 • 425 citations

Biogenesis of mRNA: Genetic Regulation in Mammalian Cells

1973 • 398 citations

General interspersion of repetitive with non-repetitive sequence elements in the DNA of Xenopus

1973 • 389 citations

An Adenylic Acid-Rich Sequence in Messenger RNA of HeLa Cells and Its Possible Relationship to Reiterated Sites in DNA

1971 • 389 citations

MORPHOLOGICAL STUDIES OF TRANSCRIPTION

1972 • 378 citations

THE ANATOMY AND FUNCTION OF A SEGMENT OF THE X CHROMOSOME OF DROSOPHILA MELANOGASTER

1972 • 363 citations

Adenine-rich Polymer associated with Rabbit Reticulocyte Messenger RNA

1970 • 355 citations

Evidence that all messenger RNA molecules (except histone messenger RNA) contain poly(A) sequences and that the poly(A) has a nuclear function

1972 • 354 citations

Lampbrush chromosomes of crested newtsTriturus cristatus(Laurenti)

1960 • 343 citations

Giant-size rapidly labeled nuclear ribonucleic acid and cytoplasmic messenger ribonucleic acid in immature duck erythrocytes

1966 • 331 citations

Polyadenylic Acid Segment in mRNA Becomes Shorter with Age

1973 • 317 citations

Haemoglobin Constant Spring—A Chain Termination Mutant ?

1971 • 305 citations

Regulation of protein synthesis in HeLa cells: Translation at elevated temperatures

1969 • 302 citations

High Stability of Messenger RNA in Growing Cultured Cells

1972 • 300 citations

The organization of genetic units in chromosomes

1967 • 299 citations

Nucleotide Sequence Repetition: A Rapidly Reassociating Fraction of Mouse DNA

1966 • 288 citations

The genes for silk fibroin in Bombyx mori

1972 • 288 citations

Isolation and Identification of the messenger RNA for silk fibroin from Bombyx mori

1972 • 284 citations

Reiteration and Clustering of DNA Sequences Complementary to Histone Messenger RNA

1971 • 259 citations

Rapidly labeled, polyribosome-associated RNA having the properties of histone messenger.

1967 • 258 citations

Messenger and Heterogeneous Nuclear RNA in HeLa Cells: Differential Inhibition by Cordycepin

1970 • 253 citations

The Isolation and Characterization of Adenosine Monophosphate-rich Polynucleotides Synthesized by Ehrlich Ascites Cells

1969 • 248 citations

Role of DNA and Specific Cytoplasmic Receptors in Glucocorticoid Action

1972 • 248 citations

Chromatid structure: relationship between DNA content and nucleotide sequence diversity

1971 • 241 citations

Further evidence on the nuclear origin and transfer to the cytoplasm of polyadenylic acid sequences in mammalian cell RNA

1973 • 240 citations

Evidence for Ribonucleic Acid Molecules Restricted to the Cell Nucleus^*

1967 • 229 citations

Addition of Polyadenylate Sequences to Virus-Specific RNA during Adenovirus Replication

1971 • 226 citations

Dependence of the sedimentation coefficient on molecular weight of RNA after reaction with formaldehyde

1968 • 223 citations

THE TURNOVER OF NUCLEAR DNA-LIKE RNA IN HELA CELLS

1968 • 219 citations

On the structural organization of operon and the regulation of RNA synthesis in animal cells

1969 • 216 citations

Embryology and Genetics

1934 • 202 citations

Messenger RNA turnover in mouse L cells

1973 • 201 citations

Histone Synthesis in Vitro on HeLa Cell Microsomes

1969 • 198 citations

Different Sequences for 5S RNA in Kidney Cells and Ovaries of Xenopus laevis

1973 • 188 citations

Physiology of rat-liver polysomes. The stability of messenger ribonucleic acid and ribosomes

1967 • 185 citations

Patterns of RNA metabolism in a differentiated cell: a rapidly labeled, unstable 60S RNA with messenger properties in duck erythroblasts.

1966 • 174 citations

A reconstituted cell-free system for the specific transfer of steroid–receptor complexes into nuclear chromatin isolated from rat ventral prostate gland

1971 • 170 citations

Hydridization of ribonucleic acid with unique sequences of mouse deoxyribonucleic acid

1972 • 166 citations

Properties of mouse globin messenger ribonucleic acid and its preparationn milligram quantities

1971 • 165 citations

Purification and Some Characteristics of 5S DNA from Xenopus laevis

1971 • 162 citations

Demonstration of Globin Messenger Sequences in Giant Nuclear Precursors of Messenger RNA of Avian Erythroblasts

1973 • 159 citations

Messenger RNA in avian erythroblasts at the transcriptional and translational levels and the problem of regulation in animal cells

1968 • 155 citations

Chapter 4 The Cocoonase Zymogen Cells of Silk Moths: A Model of Terminal Cell Differentiation For Specific Protein Synthesis

1972 • 150 citations

Genetic information in oocyte RNA

1971 • 143 citations

IDENTITY OF DNA AND DIVERSITY OF MESSENGER RNA MOLECULES IN NORMAL MOUSE TISSUES

1964 • 142 citations

The nature of Lactose operator constitutive mutations

1971 • 141 citations

Transcription of Nonrepeated DNA in Mouse Brain

1971 • 139 citations

Reiteration Frequency of Haemoglobin Genes in the Duck

1972 • 137 citations

Post-fertilization Synthesis of Polyadenylic Acid in Sea Urchin Embryos

1972 • 131 citations

Evidence for Single Copies of Globin Genes in the Mouse Genome

1972 • 129 citations

DNA-RNA hybridization in vast DNA excess.

1971 • 129 citations

Metabolism of small molecular weight monodisperse nuclear RNA

1969 • 128 citations

Sequence diversity of polytene chromosome DNA from Drosophila hydei

1971 • 126 citations

Proportion of the HeLa cell genome complementary to transfer RNA and 5 s RNA

1971 • 119 citations

Changes in the expression of single-copy DNA during development of the cellular slime mold Dictyostelium discoideum

1972 • 116 citations

THE RELATIVE MUTABILITIES OF DNA IN REGIONS OF THE X CHROMOSOME OF DROSOPHILA MELANOGASTER

1965 • 115 citations

Genes Coding for Polysomal 9S RNA of Sea Urchins: Conservation and Divergence

1972 • 114 citations

Unstable nuclear RNA synthesis following estrogen stimulation

1970 • 113 citations

SV40-Specific RNA in the Nucleus and Polyribosomes of Transformed Cells

1970 • 109 citations

Isolation and Hybridization Kinetics of Messenger RNA from Dictyostelium discoideum

1972 • 109 citations

Localization of polyadenylic acid sequences in messenger ribonucleic acid of mammalian cells

1972 • 107 citations

Localization of the Polyadenylate Sequences in Messenger Ribonucleic Acid and in the Heterogeneous Nuclear Ribonucleic Acid of HeLa Cells

1973 • 105 citations

Early appearance of histone messenger RNA in polyribosomes of cultured L cells

1972 • 104 citations

Soluble Complexes between Steroid Hormones and Target-Tissue Receptors Bind Specifically to Target-Tissue Chromatin

1971 • 103 citations

MOLECULAR CHARACTERIZATION OF THE DROSOPHILA GENOME

1969 • 102 citations

Denaturation map of the ribosomal DNA of Xenopus laevis

1971 • 102 citations

The molecular weight of rabbit globin messenger RNA's

1973 • 100 citations

Giant RNA Transcript in a Balbiani Ring

1972 • 97 citations

ANALYSIS OF CHROMOSOME 4 IN DROSOPHILA MELANOGASTER . II: ETHYL METHANESULFONATE INDUCED LETHALS

1971 • 94 citations

Visualisation in the Electron Microscope and Size of RNA from Animal Cells

1969 • 94 citations

Changes in the concentration of high-affinity oestradiol receptors in rat uterine supernatant preparations during the oestrous cycle, pseudopregnancy, pregnancy, maturation and after ovariectomy

1970 • 93 citations

HYBRIDIZATION PROPERTIES OF DNA SEQUENCES DIRECTING THE SYNTHESIS OF MESSENGER RNA AND HETEROGENEOUS NUCLEAR RNA

1971 • 92 citations

Synthesis and decay rates of major classes of deoxyribonucleic acid-like ribonucleic acid in sea urchin embryos

1971 • 91 citations

Transcription of the Polyoma Virus Genome: Synthesis and Cleavage of Giant Late Polyoma-Specific RNA

1971 • 91 citations

Receptor-Estrogen Complex in the Nuclear Fraction of Rat Uterine Cells during the Estrous Cycle

1972 • 88 citations

Studies on Liver Messenger Ribonucleic Acid

1964 • 87 citations

On the structure of transcriptional unit in mammalian cells

1972 • 86 citations

Reiteration Frequency of Duck Haemoglobin Genes

1973 • 85 citations

Nuclear and Cytoplasmic Messenger-like RNA and Their Relation to the Active Messenger RNA in Polyribosomes of HeLa Cells

1970 • 85 citations

Unexpectedly Large Size of Globin Messenger Ribonucleic Acid

1971 • 84 citations

Calf and Pea Histone IV

1968 • 84 citations

LETHALITY PATTERNS AND MORPHOLOGY OF SELECTED LETHAL AND SEMI-LETHAL MUTATIONS IN THE ZESTE-WHITE REGION OF DROSOPHILA MELANOGASTER

1972 • 83 citations

Note on the control of gene expression during development

1971 • 83 citations

Presence of Cell and Virus Specific Sequences in the Same Molecules of Nuclear RNA from Virus Transformed Cells

1971 • 83 citations

Transcription of Nonrepeated DNA in Neonatal and Fetal Mice

1971 • 83 citations

Chromosomal RNA: Its Properties

1972 • 82 citations

STABILITIES OF NUCLEAR AND MESSENGER RNA MOLECULES IN SEA URCHIN EMBRYOS

1972 • 82 citations

Characterization of RNA in fractions of calf thymus chromatin

1971 • 80 citations

Stability of Cytoplasmic Messenger RNA in HeLa Cells

1973 • 78 citations

The nature of messenger RNA in the early stages of sea urchin development.

1966 • 78 citations

Polyadenylic acid sequences on 3' termini of vaccinia messenger ribonucleic acid and mammalian nuclear and messenger ribonucleic acid

1972 • 77 citations

Rate of nuclear ribonucleic acid turnover in sea urchin embryos

1969 • 76 citations

Ribonucleic acid synthesis in regenerating and embryonic liver

1967 • 76 citations

Evidence for Transport of 75S RNA from a Discrete Chromosome Region via Nuclear Sap to Cytoplasm in Chironomus tentans

1973 • 75 citations

The Isolation and Purification of Rapidly Labeled Polysome-bound Ribonucleic Acid on Polythymidylate Cellulose

1972 • 75 citations

Size and distribution of the repetitive segments of the Drosophila genome

1972 • 75 citations

Arrangement of the highly reiterated DNA sequences in the centric heterochromatin of Drosophila melanogaster evidence for interspersed spacer DNA

1972 • 75 citations

Mitochondrial RNA in Xenopus laevis

1972 • 71 citations

Transcription of nonrepeated DNA during mouse and rabbit development

1972 • 71 citations

Chromosomal RNA: An artifact of preparation?

1971 • 68 citations

A comparison of globin genes in duck reticulocytes and liver cells

1972 • 67 citations

Fine structure analysis of a chromosome segment in Drosophila melanogaster analysis of ethyl methanesulphonate-induced lethals

1969 • 65 citations

Globin Messenger Sequences in High Molecular Weight RNA from Embryonic Mouse Liver

1973 • 64 citations

A COMPARISON BETWEEN HETEROGENEOUS NUCLEAR RNA AND POLYSOMAL MESSENGER RNA IN HELA CELLS BY RNA-DNA HYBRIDIZATION

1970 • 64 citations

Repeated DNA sequences in a Balbiani ring

1972 • 61 citations

Relative Effect of Transcription-Level and Translation-Level Control of Protein Synthesis during Early Development of the Sea Urchin

1970 • 60 citations

Modified Nucleosides of Nuclear and Nucleolar Low Molecular Weight Ribonucleic Acid

1972 • 60 citations

Fractionation of heterogeneous nuclear RNA: Rates of hybridization and chrosomal distribution of reiterated sequences

1970 • 59 citations

Renaturation of bacteriophage φX174 DNA-RNA hybrid: RNA length effect and nucleation rate constant

1973 • 57 citations

Effect of estrogen on gene expression in the chick oviduct. II. Transcription of chick tritiated unique deoxyribonucleic acid as measured by hybridization in ribonucleic acid excess

1973 • 57 citations

The nature and fate ofRana pipiens proteins synthesized during maturation and early cleavage

1971 • 57 citations

On Estimating Functional Gene Number in Eukaryotes

1973 • 56 citations

The distribution of rapidly hybridizing RNA sequences in heterogeneous nuclear RNA and mRNA from hela cells

1970 • 55 citations

Fine structure analysis of a chromosome segment in Drosophila melanogaster analysis of X-ray-induced lethals

1968 • 54 citations

Cell-free Synthesis of Histories directed by Messenger RNA from Sea Urchin Embryos

1973 • 53 citations

Chromosome Puffs and Gene Expression in Polytene Cells

1974 • 49 citations

Chapter 1 The Structure of Transcriptional Units In Eukaryotic Cells

1972 • 48 citations

mRNA STABILITY AND CELLULAR DIFFERENTIATION

1972 • 46 citations

Formation of rings from Drosophila DNA fragments

1973 • 45 citations

Specific inhibition by ATP and other properties of an endonuclease of Neurospora crassa

1968 • 45 citations

Characterization of rapidly labeled RNA in Tetrahymena pyriformis

1971 • 44 citations

Hybridization Properties and Sequence Arrangement in a Population of mRNAs

1973 • 41 citations

A Proposal for the Structure of the Drosophila Genome

1973 • 40 citations

Stage-specific initiation factors for protein synthesis during insect development

1971 • 38 citations

Characterization of RNAs That Do and Do Not Migrate between Cytoplasm and Nucleus

1970 • 37 citations

A stabilization of RNA templates in lens cell differentiation.

1967 • 37 citations

Selective measurement of the synthesis and metabolic stability of messenger RNA in 3T3 mouse cells

1970 • 36 citations

Regulated Expression of Mammalian Genes: Globin and Immunoglobulin as Model Systems

1974 • 35 citations

Messenger RNAs for Individual Histone Proteins: Fingerprint Analysis and In Vitro Translation

1974 • 33 citations

Physico-chemical properties of chromosomal RNA in Chironomus tentans polytene chromosomes

1969 • 33 citations

Change in repeated DNA in evolution.

1972 • 30 citations

A comparison of gel electrophoresis and density gradient centrifugation of heterogeneous nuclear RNA

1972 • 29 citations

Tissue Differences in Rat Chromosomal RNA

1971 • 29 citations

The transfer of proteins from cytoplasm to nucleus in HeLa cells

1968 • 29 citations

Interaction between polyuridylic acid and rabbit globin messenger ribonucleic acid

1973 • 29 citations

Sequence repetition in the DNA of Nassaria (Ilyanassa) obsoleta

1971 • 26 citations

The Biosynthesis of Protamine in Trout Testis

1970 • 26 citations

Disaggregation of “giant” heterogeneous nuclear RNA of mouse Ehrlich ascites cells by thermal denaturation in the presence of formaldehyde

1971 • 25 citations

Regional organization of eukaryotic DNA sequences as studied by the formation of folded rings

1973 • 25 citations

Studies on the turnover of mRNA in free and membrane-bound polyribosomes in rat liver

1972 • 22 citations

Amplification and evolution of deoxyribonucleic acid sequences expressed as ribonucleic acid

1973 • 22 citations

Tissue Specificity of Genetic Transcription

1972 • 16 citations

Stability and fine structure of eukaryotic DNA rings in formamide

1973 • 16 citations

DNA sequence interspersion and a speculation about evolution.

1972 • 15 citations

The integrity of “giant” nuclear RNA

1973 • 15 citations

The intracellular distribution of the free amino acid pool in frog oocytes

1969 • 15 citations

Molecular hybridization used to characterize the RNA synthesized by isolated bovine thymus nuclei.

1968 • 13 citations