Cytosolic receptor for aryl hydrocarbon hydroxylase induction by polycyclic aromatic compounds. Evidence for structural and regulatory variants among established cell cultured lines.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONS

1949 • 19,979 citations

Pharmacological implications of microsomal enzyme induction.

1967 • 2,883 citations

Stereospecific, high affinity binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin by hepatic cytosol. Evidence that the binding species is receptor for induction of aryl hydrocarbon hydroxylase.

1976 • 1,343 citations

Current Models of Steroid Hormone Action: A Critique

1976 • 707 citations

Temporal Control of Puffing Activity in Polytene Chromosomes

1974 • 632 citations

Glucocorticoid receptors: Relations between steroid binding and biological effects

1972 • 554 citations

Properties of electrophoretically homogeneous phenobarbital-inducible and beta-naphthoflavone-inducible forms of liver microsomal cytochrome P-450

1976 • 536 citations

Induction of tyrosine alpha-ketoglutarate transaminase by steroid hormones in a newly established tissue culture cell line.

1966 • 484 citations

Purified liver microsomal cytochrome P-450. Separation and characterization of multiple forms.

1975 • 456 citations

Organization, Transcription, and Regulation in the Animal Genome

1973 • 454 citations

In vitro metabolic activation in mutagenesis testing

1976 • 434 citations

The metabolism of methylated aminoazo dyes. V. Evidence for induction of enzyme synthesis in the rat by 3-methylcholanthrene.

1956 • 393 citations

Specific Cytoplasmic Glucocorticoid Hormone Receptors in Hepatoma Tissue Culture Cells

1971 • 328 citations

Genetic Expression of Aryl Hydrocarbon Hydroxylase Activity

1974 • 326 citations

Progesterone-binding Components of Chick Oviduct

1970 • 321 citations

Enzyme synthesis and degradation in mammalian systems

1971 • 310 citations

A Transplantable Bile-Secreting Hepatocellular Carcinoma in the Rat<xref ref-type="fn" rid="FN1">2</xref><xref ref-type="fn" rid="FN2">3</xref>

1961 • 248 citations

Genetic variation of aryl hydrocarbon hydroxylase in human lymphocytes.

1973 • 248 citations

Genetic expression of aryl hydrocarbon hydroxylase activity in the mouse

1975 • 245 citations

Genetic Expression of Aryl Hydrocarbon Hydroxylase by 2,3,7,8-Tetrachlorodibenzo-p-dioxin: Evidence for a Receptor Mutation in Genetically Non-responsive Mice

1975 • 238 citations

Induction of multiple forms of mouse liver cytochrome P-450. Evidence for genetically controlled de novo protein synthesis in response to treatment with beta-naphthoflavone or phenobarbital.

1976 • 229 citations

Chlorinated dibenzo-p-dioxins: potent inducers of delta-aminolevulinic acid synthetase and aryl hydrocarbon hydroxylase. II. A study of the structure-activity relationship.

1973 • 218 citations

Target Tissue Receptors for Progesterone: The Influence of Estrogen Treatment1

1972 • 194 citations

The Ah Locus and the Metabolism of Chemical Carcinogens and Other Foreign Compounds

1977 • 188 citations

Expression of liver phenotypes in cultured mouse hepatoma cells: Synthesis and secretion of serum albumin

1973 • 171 citations

Genetic regulation of UDP-glucuronosyltransferase induction by polycyclic aromatic compounds in mice. Co-segregation with aryl hydrocarbon (benzo(alpha)pyrene) hydroxylase induction.

1977 • 155 citations

Multiple forms of cytochrome P-450 in phenobarbital- and 3-methylcholanthrene-treated rats. Separation and spectral properties.

1975 • 150 citations

Androgen receptor in rat liver: Hormonal and developmental regulation of the cytoplasmic receptor and its correlation with the androgen-dependent synthesis of α2u-globulin

1974 • 134 citations

Immunochemical evidence for six forms of rat liver cytochrome P450 obtained using antibodies against purified rat liver cytochromes P450 and P448.

1976 • 133 citations

Genetic control of interindividual variations in the inducibility of aryl hydrocarbon hydroxylase in cultured human lymphocytes.

1976 • 126 citations

Comparison of beta-naphthoflavone and 3-methylcholanthrene as inducers of hepatic cytochrome(s) P-448 and aryl hydrocarbon (benzo[a]pyrene) hydroxylase activity.

1977 • 119 citations

Aryl hydrocarbon hydroxylase induction in mammalian liver-derived cell cultures. Stimulation of "cytochrome P1-450-associated" enzyme activity by many inducing compounds.

1975 • 109 citations

Genetic differences in induction of cytosol reduced-NAD(P):menadione oxidoreductase and microsomal aryl hydrocarbon hydroxylase in the mouse.

1977 • 109 citations

Aryl Hydrocarbon Hydroxylase Induction in Mammalian Liver Cell Culture

1971 • 108 citations

Genetic Differences in the Extent of Aryl Hydrocarbon Hydroxylase Induction in Mouse Fetal Cell Cultures

1970 • 96 citations

Mutagenesis of certain activated carcinogens in vitro associated with genetically mediated increases in monooxygenase activity and cytochrome P 1-450.

1975 • 84 citations

Induction of Aryl Hydrocarbon Hydroxylase Activity in Various Cell Cultures by 2,3,7,8-Tetrachlorodibenzo-p-dioxin

1975 • 75 citations

Genetic and Enzymatic Experiments Relating to the Tertiary Structure of β-Galactosidase

1968 • 72 citations

Cytoplasmic glucocorticoid-binding proteins in glucocorticoid-unresponsive human and mouse leukemic cell lines.

1974 • 70 citations

Mechanisms of Drug Action at the Voluntary Muscle Endplate

1975 • 66 citations

Aryl Hydrocarbon Hydroxylase Induction in Mammalian Liver Cell Culture

1971 • 66 citations

Aryl hydrocarbon hydroxylase induction in mammalian liver cell culture—IV. Stimulation of the enzyme activity in established cell lines derived from rat or mouse hepatoma and from normal rat liver

1973 • 62 citations

Chromosome Puffs and Gene Expression in Polytene Cells

1974 • 49 citations

Mechanism of Action of the Sex Steroid Hormones

1976 • 49 citations

Genetic differences in 2-acetylaminofluorene mutagenicity in vitro associated with mouse hepatic aryl hydrocarbon hydroxylase activity induced by polycyclic aromatic compounds.

1976 • 48 citations

Aryl hydrocarbon hydroxylase induction in mammalian liver-derived cell cultures

1976 • 39 citations

Fate of inducer during induction of aryl hydrocarbon hydroxylase activity in mammalian cell culture. I. Intracellular entry, binding, distribution, and metabolism.

1970 • 28 citations

Fate of inducer during induction of aryl hydrocarbon hydroxylase activity in mammalian cell culture. II. Levels of intracellular polycyclic hydrocarbon during enzyme induction and decay.

1970 • 26 citations

THE MURINE Ah LOCUS AND DYSMORPHOGENESIS

1977 • 15 citations

Co-operativity in the cyclic model for drug-receptor interaction

1976 • 4 citations