'Slip, sliding away': phospholipase D and the Golgi apparatus

ADP-ribosylation factor, a small GTP-dependent regulatory protein, stimulates phospholipase D activity

1993 • 900 citations

Phosphatidylinositol 4-Phosphate 5-Kinase α Is a Downstream Effector of the Small G Protein ARF6 in Membrane Ruffle Formation

1999 • 800 citations

Phospholipase D2, a distinct phospholipase D isoform with novel regulatory properties that provokes cytoskeletal reorganization

1997 • 698 citations

Human ADP-ribosylation Factor-activated Phosphatidylcholine-specific Phospholipase D Defines a New and Highly Conserved Gene Family

1995 • 663 citations

Phospholipase D: a Downstream Effector of ARF in Granulocytes

1994 • 636 citations

Characterization of Two Alternately Spliced Forms of Phospholipase D1

1997 • 547 citations

Endophilin I mediates synaptic vesicle formation by transfer of arachidonate to lysophosphatidic acid

1999 • 536 citations

ARF mediates recruitment of PtdIns-4-OH kinase-β and stimulates synthesis of PtdIns(4,5)P2 on the Golgi complex

1999 • 513 citations

Phospholipase D: molecular and cell biology of a novel gene family

2000 • 495 citations

Targeting of Golgi-Specific Pleckstrin Homology Domains Involves Both PtdIns 4-Kinase-Dependent and -Independent Components

2002 • 483 citations

Type I phosphatidylinositol 4-phosphate 5-kinase isoforms are specifically stimulated by phosphatidic acid

1994 • 410 citations

Role of Diacylglycerol in PKD Recruitment to the TGN and Protein Transport to the Plasma Membrane

2002 • 408 citations

Evidence that phospholipase D mediates ADP ribosylation factor-dependent formation of Golgi coated vesicles.

1996 • 380 citations

PI(4,5)P2 regulation of surface membrane traffic

2001 • 377 citations

Mutagenesis of phospholipase D defines a superfamily including a trans-Golgi viral protein required for poxvirus pathogenicity

1997 • 354 citations

Mutations in the CDP-choline pathway for phospholipid biosynthesis bypass the requirement for an essential phospholipid transfer protein

1991 • 348 citations

Subcellular localization of phosphatidylinositol 4,5-bisphosphate using the pleckstrin homology domain of phospholipase C δ1

2002 • 333 citations

Spectrin tethers and mesh in the biosynthetic pathway

2000 • 326 citations

A novel family of phospholipase D homologues that includes phospholipid synthases and putative endonucleases: Identification of duplicated repeats and potential active site residues

1996 • 318 citations

Mammalian phospholipase D structure and regulation

1999 • 311 citations

Phosphoinositide profiling in complex lipid mixtures using electrospray ionization mass spectrometry

2003 • 252 citations

Phospholipase D Stimulates Release of Nascent Secretory Vesicles from the trans-Golgi Network

1997 • 251 citations

The Yeast Synaptojanin-like Proteins Control the Cellular Distribution of Phosphatidylinositol (4,5)-Bisphosphate

2002 • 239 citations

Location, Location, Location: Membrane Targeting Directed by PX Domains

2001 • 237 citations

Phospholipase D—Structure, regulation and function

2007 • 234 citations

Phospholipase D signaling is essential for meiosis.

1995 • 208 citations

Phospholipase D1 localises to secretory granules and lysosomes and is plasma-membrane translocated on cellular stimulation

1998 • 200 citations

The Activation Loop of Phosphatidylinositol Phosphate Kinases Determines Signaling Specificity

2000 • 199 citations

Phospholipase D is present on Golgi-enriched membranes and its activation by ADP ribosylation factor is sensitive to brefeldin A.

1995 • 193 citations

Intracellular Localization of Phospholipase D1 in Mammalian Cells

2001 • 183 citations

Type I Phosphatidylinositol 4-Phosphate 5-Kinase Directly Interacts with ADP-ribosylation Factor 1 and Is Responsible for Phosphatidylinositol 4,5-Bisphosphate Synthesis in the Golgi Compartment

2000 • 177 citations

Peri-Golgi vesicles contain retrograde but not anterograde proteins consistent with the cisternal progression model of intra-Golgi transport

2001 • 176 citations

Identification of a phosphoinositide binding motif that mediates activation of mammalian and yeast phospholipase D isoenzymes

1999 • 174 citations

Structural Analysis of Human Phospholipase D1

1999 • 169 citations

Regulated Exocytosis in Chromaffin Cells

1998 • 165 citations

Phospholipase D activity is required for suppression of yeast phosphatidylinositol transfer protein defects

1998 • 161 citations

TAPAS-1, a Novel Microdomain within the Unique N-terminal Region of the PDE4A1 cAMP-specific Phosphodiesterase That Allows Rapid, Ca2+-triggered Membrane Association with Selectivity for Interaction with Phosphatidic Acid

2002 • 158 citations

Regulated Exocytosis in Chromaffin Cells

1997 • 148 citations

A Role for Phospholipase D (Pld1p) in Growth, Secretion, and Regulation of Membrane Lipid Synthesis in Yeast

1998 • 138 citations

Secretory Vesicle Budding from the Trans-Golgi Network Is Mediated by Phosphatidic Acid Levels

1998 • 138 citations

Relocalization of Phospholipase D Activity Mediates Membrane Formation During Meiosis

1998 • 137 citations

Phospholipase D regulation and localisation is dependent upon a phosphatidylinositol 4,5-bisphosphate-specific PH domain

2000 • 137 citations

Phosphatidylinositol 4-kinase type IIα is responsible for the phosphatidylinositol 4-kinase activity associated with synaptic vesicles

2003 • 128 citations

Differential Binding of Traffic-related Proteins to Phosphatidic Acid- or Phosphatidylinositol (4,5)- Bisphosphate-coupled Affinity Reagents

2001 • 128 citations

Lipid regulators of membrane traffic through the Golgi complex

1999 • 127 citations

ADP ribosylation factor regulates spectrin binding to the Golgi complex

1998 • 126 citations

Type II Phosphatidylinositol 4-Kinase β Is a Cytosolic and Peripheral Membrane Protein That Is Recruited to the Plasma Membrane and Activated by Rac-GTP

2002 • 125 citations

Interaction of the Type Ialpha PIPkinase with phospholipase D: a role for the local generation of phosphatidylinositol 4,5-bisphosphate in the regulation of PLD2 activity

2000 • 122 citations

Inhibition of Phosphatidic Acid Synthesis Alters the Structure of the Golgi Apparatus and Inhibits Secretion in Endocrine Cells

2000 • 115 citations

The regulation of phospholipase D by inositol phospholipids and small GTPases

2002 • 110 citations

Continual Production of Phosphatidic Acid by Phospholipase D Is Essential for Antigen-stimulated Membrane Ruffling in Cultured Mast Cells

2002 • 108 citations

Ocrl1, a PtdIns(4,5)P₂ 5-Phosphatase, Is Localized to the Trans-Golgi Network of Fibroblasts and Epithelial Cells

2000 • 101 citations

Dual role for phosphoinositides in regulation of yeast and mammalian phospholipase D enzymes

2002 • 99 citations

Activated ADP-ribosylation Factor Assembles Distinct Pools of Actin on Golgi Membranes

2000 • 93 citations

Phospholipase D2 Is Localized to the Rims of the Golgi Apparatus in Mammalian Cells

2002 • 79 citations

Phosphatidylinositol transfer proteins: the long and winding road to physiological function

1998 • 79 citations

Antigen-stimulated Activation of Phospholipase D1b by Rac1, ARF6, and PKCα in RBL-2H3 Cells

2002 • 79 citations

Fragmentation of the Golgi Apparatus

2003 • 58 citations

Phosphorylation-dependent Regulation of Phospholipase D2 by Protein Kinase Cδ in Rat Pheochromocytoma PC12 Cells

2002 • 57 citations

Fatty Acylation of Phospholipase D1 on Cysteine Residues 240 and 241 Determines Localization on Intracellular Membranes

1999 • 55 citations

Phospholipase D1 is located and activated by protein kinase Cα in the plasma membrane in 3Y1 fibroblast cell

1999 • 43 citations

Effects of Activated ADP-ribosylation Factors on Golgi Morphology Require neither Activation of Phospholipase D1 nor Recruitment of Coatomer

2000 • 42 citations

Differential Regulation of Saccharomyces cerevisiae Phospholipase D in Sporulation and Sec14-Independent Secretion

2002 • 31 citations

Hierarchy of Membrane-targeting Signals of Phospholipase D1 Involving Lipid Modification of a Pleckstrin Homology Domain

2002 • 29 citations

Regulated exocytosis in chromaffin cells. Translocation of ARF6 stimulates a plasma membrane-associated phospholipase

1998 • 2 citations