Live-cell imaging of cAMP dynamics

A Protein Binding Assay for Adenosine 3′:5′-Cyclic Monophosphate

1970 • 3,269 citations

Cyclic Nucleotide-Gated Ion Channels

2002 • 1,116 citations

Discrete Microdomains with High Concentration of cAMP in Stimulated Rat Neonatal Cardiac Myocytes

2002 • 843 citations

Fluorescence ratio imaging of cyclic AMP in single cells

1991 • 686 citations

Novel Single Chain cAMP Sensors for Receptor-induced Signal Propagation

2004 • 665 citations

Adenosine 3‘, 5‘-Monophosphate in Biological Materials

1965 • 597 citations

Genetically encoded reporters of protein kinase A activity reveal impact of substrate tethering

2001 • 583 citations

Spatially Resolved Dynamics of cAMP and Protein Kinase A Subunits in Aplysia Sensory Neurons

1993 • 549 citations

A genetically encoded, fluorescent indicator for cyclic AMP in living cells

1999 • 476 citations

The elemental principles of calcium signaling

1995 • 455 citations

Fluorescent indicators of cAMP and Epac activation reveal differential dynamics of cAMP signaling within discrete subcellular compartments

2004 • 446 citations

Detecting cAMP‐induced Epac activation by fluorescence resonance energy transfer: Epac as a novel cAMP indicator

2004 • 445 citations

Compartments of cyclic AMP and protein kinase in mammalian cardiomyocytes.

1983 • 428 citations

Fluorescence Resonance Energy Transfer–Based Analysis of cAMP Dynamics in Live Neonatal Rat Cardiac Myocytes Reveals Distinct Functions of Compartmentalized Phosphodiesterases

2004 • 385 citations

Cyclic AMP Imaging in Adult Cardiac Myocytes Reveals Far-Reaching β ₁ -Adrenergic but Locally Confined β ₂ -Adrenergic Receptor–Mediated Signaling

2006 • 341 citations

Use of a cAMP BRET Sensor to Characterize a Novel Regulation of cAMP by the Sphingosine 1-Phosphate/G13 Pathway

2007 • 317 citations

Calcium-Calmodulin Modulation of the Olfactory Cyclic Nucleotide-Gated Cation Channel

1994 • 312 citations

Subcellular dynamics of protein kinase A activity visualized by FRET-based reporters

2006 • 286 citations

A uniform extracellular stimulus triggers distinct cAMP signals in different compartments of a simple cell

2001 • 282 citations

Cyclic Nucleotide–Gated Channels Colocalize with Adenylyl Cyclase in Regions of Restricted Camp Diffusion

2000 • 266 citations

Oscillations of cyclic AMP in hormone-stimulated insulin-secreting β-cells

2006 • 248 citations

Calcium signalling: Past, present and future

2005 • 232 citations

Dynamic Regulation of cAMP Synthesis through Anchored PKA-Adenylyl Cyclase V/VI Complexes

2006 • 212 citations

Gammaflow: A Completely Automated Radioimmunoassay System

1976 • 203 citations

Interplay of Ca2+ and cAMP Signaling in the Insulin-secreting MIN6 β-Cell Line

2005 • 201 citations

An anchored PKA and PDE4 complex regulates subplasmalemmal cAMP dynamics

2006 • 182 citations

PGE1 stimulation of HEK293 cells generates multiple contiguous domains with different [cAMP]: role of compartmentalized phosphodiesterases

2006 • 180 citations

Dynamic interactions of cyclic AMP transients and spontaneous Ca2+ spikes

2002 • 177 citations

In Vivo Assessment of Local Phosphodiesterase Activity Using Tailored Cyclic Nucleotide–Gated Channels as Camp Sensors

2001 • 163 citations

Spatio-temporal dynamics of cyclic AMP signals in an intact neural circuit

1996 • 155 citations

Negative Feedback Exerted by cAMP-dependent Protein Kinase and cAMP Phosphodiesterase on Subsarcolemmal cAMP Signals in Intact Cardiac Myocytes

2004 • 137 citations

Real-time Monitoring of the PDE2 Activity of Live Cells

2004 • 133 citations

Imaging protein interactions with bioluminescence resonance energy transfer (BRET) in plant and mammalian cells and tissues

2007 • 131 citations

Imaging of cAMP Levels and Protein Kinase A Activity Reveals That Retinal Waves Drive Oscillations in Second-Messenger Cascades

2006 • 127 citations

Direct in vivo monitoring of sarcoplasmic reticulum Ca2+ and cytosolic cAMP dynamics in mouse skeletal muscle

2006 • 124 citations

Calcium/Calmodulin Modulation of Olfactory and Rod Cyclic Nucleotide-gated Ion Channels

2003 • 111 citations

Ca2+ stimulation of adenylyl cyclase generates dynamic oscillations in cyclic AMP

2006 • 97 citations

Muscarinic cholinergic receptors of two cell lines that regulate cyclic AMP metabolism by different molecular mechanisms.

1984 • 91 citations

β-Adrenergic- and muscarinic receptor-induced changes in cAMP activity in adult cardiac myocytes detected with FRET-based biosensor

2005 • 71 citations

Novel, isotype-specific sensors for protein kinase A subunit interaction based on bioluminescence resonance energy transfer (BRET)

2006 • 67 citations

Adenovirus-mediated Expression of an Olfactory Cyclic Nucleotide-gated Channel Regulates the Endogenous Ca2+-inhibitable Adenylyl Cyclase in C6-2B Glioma Cells

1999 • 40 citations

Adenovirus encoded cyclic nucleotide‐gated channels: a new methodology for monitoring cAMP in living cells

2001 • 36 citations

5-HT-receptor-induced changes of the intracellular cAMP level monitored by a hyperpolarization-activated cation channel

2002 • 34 citations

High-throughput real-time monitoring of Gs-coupled receptor activation in intact cells using cyclic nucleotide-gated channels

2003 • 31 citations