Inhibition of vascular endothelial growth factor reduces angiogenesis and modulates immune cell infiltration of orthotopic breast cancer xenografts

Inflammation and cancer

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Angiogenesis in cancer, vascular, rheumatoid and other disease

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Paclitaxel plus Bevacizumab versus Paclitaxel Alone for Metastatic Breast Cancer

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Paradoxical roles of the immune system during cancer development

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The role of myeloid cells in the promotion of tumour angiogenesis

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Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling

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Association of macrophage infiltration with angiogenesis and prognosis in invasive breast carcinoma.

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Infiltrating neutrophils mediate the initial angiogenic switch in a mouse model of multistage carcinogenesis

2006 • 864 citations

Tumor refractoriness to anti-VEGF treatment is mediated by CD11b+Gr1+ myeloid cells

2007 • 831 citations

Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1

2003 • 758 citations

Clodronate-liposome-mediated depletion of tumour-associated macrophages: a new and highly effective antiangiogenic therapy approach

2006 • 596 citations

Mechanism of Immune Dysfunction in Cancer Mediated by Immature Gr-1+ Myeloid Cells

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Murine Models to Evaluate Novel and Conventional Therapeutic Strategies for Cancer

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Tumor-Associated Macrophages Press the Angiogenic Switch in Breast Cancer

2007 • 437 citations

Statistical significance of quantitative PCR

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Derangement of immune responses by myeloid suppressor cells

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Evolving Strategies for the Management of Hand–Foot Skin Reaction Associated with the Multitargeted Kinase Inhibitors Sorafenib and Sunitinib

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Comparing sequences without using alignments: application to HIV/SIV subtyping

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Inflammatory cell infiltration of tumors: Jekyll or Hyde

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Selective inhibition of vascular endothelial growth factor (VEGF) receptor 2 (KDR/Flk-1) activity by a monoclonal anti-VEGF antibody blocks tumor growth in mice.

2000 • 309 citations

Pathways Mediating the Expansion and Immunosuppressive Activity of Myeloid-Derived Suppressor Cells and Their Relevance to Cancer Therapy

2007 • 265 citations

Vascular Endothelial Growth Factor Receptor-1 Activation Mediates Epithelial to Mesenchymal Transition in Human Pancreatic Carcinoma Cells

2006 • 260 citations

Vascular Endothelial Growth Factor Mediates Intracrine Survival in Human Breast Carcinoma Cells through Internally Expressed VEGFR1/FLT1

2007 • 259 citations

Inflammation, inflammatory cells and angiogenesis: decisions and indecisions

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Monitoring Response to Anticancer Therapy by Targeting Microbubbles to Tumor Vasculature

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Differential Roles of Vascular Endothelial Growth Factor Receptors 1 and 2 in Dendritic Cell Differentiation

2005 • 231 citations

Prognostic value of tumor‐infiltrating dendritic cells expressing CD83 in human breast carcinomas

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Distinct roles of VEGFR-1 and VEGFR-2 in the aberrant hematopoiesis associated with elevated levels of VEGF

2007 • 210 citations

Plasticity in Tumor-Promoting Inflammation: Impairment of Macrophage Recruitment Evokes a Compensatory Neutrophil Response

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Macrophage phagocytosis of apoptotic neutrophils is critically regulated by the opposing actions of pro‐inflammatory and anti‐inflammatory agents: key role for TNF‐α

2008 • 205 citations

Vascular Endothelial Growth Factor Receptor 2 Mediates Macrophage Infiltration into Orthotopic Pancreatic Tumors in Mice

2008 • 195 citations

High levels of vascular endothelial growth factor and its receptors (VEGFR-1, VEGFR-2, neuropilin-1) are associated with worse outcome in breast cancer

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Vascular endothelial growth factor induces proliferation of breast cancer cells and inhibits the anti-proliferative activity of anti-hormones

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Ultrastructural Localization of the Vascular Permeability Factor/Vascular Endothelial Growth Factor (VPF/VEGF) Receptor-2 (FLK-1, KDR) in Normal Mouse Kidney and in the Hyperpermeable Vessels Induced by VPF/VEGF-expressing Tumors and Adenoviral Vectors

2000 • 119 citations

Hypoxia is responsible for soluble vascular endothelial growth factor receptor-1 (VEGFR-1) but not for soluble endoglin induction in villous trophoblast

2008 • 116 citations

A monoclonal antibody that blocks VEGF binding to VEGFR2 (KDR/Flk-1) inhibits vascular expression of Flk-1 and tumor growth in an orthotopic human breast cancer model.

2002 • 104 citations

Vascular endothelial growth factor VEGF189 induces human neutrophil chemotaxis in extravascular tissue via an autocrine amplification mechanism

2004 • 98 citations

Loss of SPARC-mediated VEGFR-1 suppression after injury reveals a novel antiangiogenic activity of VEGF-A

2006 • 94 citations

Anti‐VEGF‐A therapy reduces lymphatic vessel density and expression of VEGFR‐3 in an orthotopic breast tumor model

2007 • 92 citations

Expression of Vascular Endothelial Growth Factor (VEGF) and VEGF Receptors in Tumor Angiogenesis and Malignancies

2005 • 85 citations

Homeostatic Modulation of Cell Surface KDR and Flt1 Expression and Expression of the Vascular Endothelial Cell Growth Factor (VEGF) Receptor mRNAs by VEGF

2000 • 69 citations

Neuropilin‐1 and neuropilin‐2 enhance VEGF₁₂₁stimulated signal transduction by the VEGFR‐2 receptor

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Inhibition of carcinoma cell‐derived VEGF reduces inflammatory characteristics in xenograft carcinoma

2006 • 61 citations

Evaluation of Novel Antimouse VEGFR2 Antibodies as Potential Antiangiogenic or Vascular Targeting Agents for Tumor Therapy

2003 • 43 citations

IFN-γ acts as anti-angiogenic cytokine in the human cornea by regulating the expression of VEGF-A and sVEGF-R1

2008 • 41 citations

Upregulation of placental growth factor by vascular endothelial growth factor via a post‐transcriptional mechanism

2005 • 38 citations

Selective Blockade of Vascular Endothelial Growth Factor Receptor 2 With an Antibody Against Tumor-Derived Vascular Endothelial Growth Factor Controls the Growth of Human Pancreatic Adenocarcinoma Xenografts

2006 • 28 citations