Genetic linkage studies

Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results

1995 • 5,291 citations

Estimates of the cancer incidence and mortality in Europe in 2006

2007 • 4,128 citations

Identification of the breast cancer susceptibility gene BRCA2

1995 • 3,581 citations

Merlin—rapid analysis of dense genetic maps using sparse gene flow trees

2001 • 3,369 citations

The History and Geography of Human Genes

2018 • 3,334 citations

Multipoint Quantitative-Trait Linkage Analysis in General Pedigrees

1998 • 3,077 citations

Parametric and nonparametric linkage analysis: a unified multipoint approach.

1996 • 2,905 citations

Linkage of Early-Onset Familial Breast Cancer to Chromosome 17q21

1990 • 2,505 citations

Searching for genetic determinants in the new millennium

2000 • 1,878 citations

Sequential tests for the detection of linkage.

1955 • 1,590 citations

The investigation of linkage between a quantitative trait and a marker locus

1972 • 1,398 citations

A genome-wide search for human type 1 diabetes susceptibility genes

1994 • 1,294 citations

Descent graphs in pedigree analysis: applications to haplotyping, location scores, and marker-sharing statistics.

1996 • 1,201 citations

Allele-Sharing Models: LOD Scores and Accurate Linkage Tests

1997 • 993 citations

The history and geography of human genes

1995 • 930 citations

Complete multipoint sib-pair analysis of qualitative and quantitative traits.

1995 • 929 citations

Linkage strategies for genetically complex traits. II. The power of affected relative pairs.

1990 • 886 citations

Estimates of cancer incidence and mortality in Europe in 1995

2002 • 695 citations

Genetic association studies

2005 • 588 citations

Genomewide Scans of Complex Human Diseases: True Linkage Is Hard to Find

2001 • 554 citations

A comparison of sib‐pair linkage tests for disease susceptibility loci

1985 • 407 citations

Linkage strategies for genetically complex traits. III. The effect of marker polymorphism on analysis of affected relative pairs.

1990 • 398 citations

Asymptotic properties of affected-sib-pair linkage analysis.

1993 • 378 citations

A Class of Tests for Linkage Using Affected Pedigree Members

1994 • 346 citations

Haseman and Elston revisited

2000 • 342 citations

A comprehensive linkage analysis for myocardial infarction and its related risk factors

2002 • 328 citations

Replication of Linkage Studies of Complex Traits: An Examination of Variation in Location Estimates

1999 • 282 citations

Key concepts in genetic epidemiology

2005 • 274 citations

Genome-wide mapping of human loci for essential hypertension

2003 • 266 citations

The Human Obesity Gene Map: The 2002 Update

2003 • 242 citations

Genomewide Screen and Identification of Gene-Gene Interactions for Asthma-Susceptibility Loci in Three U.S. Populations: Collaborative Study on the Genetics of Asthma

2001 • 237 citations

Whole-Genome Scan, in a Complex Disease, Using 11,245 Single-Nucleotide Polymorphisms: Comparison with Microsatellites

2004 • 228 citations

Meta‐analysis of genome searches

1999 • 209 citations

A NEW ESTIMATE OF THE LINKAGE BETWEEN THE GENES FOR COLOUR‐BLINDNESS AND HAEMOPHILIA IN MAN

1947 • 198 citations

A variance component approach to dichotomous trait linkage analysis using a threshold model

1997 • 191 citations

A Multipoint Method for Detecting Genotyping Errors and Mutations in Sibling-Pair Linkage Data

2000 • 177 citations

Genome Scan Meta-Analysis of Schizophrenia and Bipolar Disorder, Part I: Methods and Power Analysis

2003 • 155 citations

The Genetics of Adult-Onset Neuropsychiatric Disease: Complexities and Conundra?

2003 • 145 citations

A Systematic Genomewide Linkage Study in 353 Sib Pairs with Schizophrenia

2003 • 119 citations

Molecular cell biology of Charcot-Marie-Tooth disease

2002 • 117 citations

A comparison of three affected‐sib‐pair scoring methods to detect HLA‐linked disease susceptibility genes

1984 • 103 citations

Empirical genomewide significance levels established by whole genome simulations

1997 • 101 citations

Linkage of high-density lipoprotein–cholesterol concentrations to a locus on chromosome 9p in Mexican Americans

2001 • 95 citations

On the lod score method in linkage analysis

1984 • 81 citations

Evaluating the Results of Genomewide Linkage Scans of Complex Traits by Locus Counting

2002 • 79 citations

Tay-Sachs Disease — Screening and Prevention

1978 • 64 citations

Fine mapping of chromosome 3 in uveal melanoma: identification of a minimal region of deletion on chromosomal arm 3p25.1-p25.2.

2003 • 59 citations

Ehlers-Danlos Syndrome with Severe Early-Onset Periodontal Disease (EDS-VIII) Is a Distinct, Heterogeneous Disorder with One Predisposition Gene at Chromosome 12p13

2003 • 52 citations

Genetics of IDDM: Evidence for complex inheritance with HLA

1989 • 51 citations

Tay-Sachs Disease: Screening and Prevention

1979 • 49 citations

Likelihood-ratio affected sib-pair tests applied to multiply affected sibships: Issues of power and type I error rate

2000 • 10 citations