Small heat-shock protein structures reveal a continuum from symmetric to variable assemblies

Alpha-crystallin can function as a molecular chaperone.

1992 • 1,822 citations

Cryo-electron microscopy of viruses

1984 • 1,293 citations

The crystal structure of the asymmetric GroEL–GroES–(ADP)7 chaperonin complex

1997 • 1,250 citations

A New Generation of the IMAGIC Image Processing System

1996 • 1,236 citations

Crystal structure of a small heat-shock protein

1998 • 876 citations

Four small Drosophila heat shock proteins are related to each other and to mammalian alpha-crystallin.

1982 • 792 citations

Determination of the fold of the core protein of hepatitis B virus by electron cryomicroscopy

1997 • 791 citations

A small heat shock protein stably binds heat-denatured model substrates and can maintain a substrate in a folding-competent state

1997 • 772 citations

The Crystal Structure of the Human Hepatitis B Virus Capsid

1999 • 638 citations

Angular reconstitution: A posteriori assignment of projection directions for 3D reconstruction

1987 • 600 citations

αB subunit of lens-specific protein α-crystallin is present in other ocular and non-ocular tissues

1989 • 538 citations

Alpha B-crystallin is a small heat shock protein.

1991 • 526 citations

Genealogy of the α-crystallin—small heat-shock protein superfamily

1998 • 480 citations

Visualization of a 4-helix bundle in the hepatitis B virus capsid by cryo-electron microscopy

1997 • 467 citations

Difference imaging of adenovirus: bridging the resolution gap between X-ray crystallography and electron microscopy.

1993 • 378 citations

Structure and Modifications of the Junior Chaperone α‐Crystallin

1994 • 374 citations

Similarity measures between images

1987 • 353 citations

HSP27 Multimerization Mediated by Phosphorylation-sensitive Intermolecular Interactions at the Amino Terminus

1999 • 324 citations

GroEL-GroES Cycling

1999 • 303 citations

α-Crystallin as a molecular chaperone

1999 • 288 citations

The small heat-shock protein, αb-crystallin, has a variable quaternary structure

1998 • 286 citations

Subunit Exchange of αA-Crystallin

1997 • 286 citations

A 9 Å Resolution X-Ray Crystallographic Map of the Large Ribosomal Subunit

1998 • 261 citations

alpha A-crystallin is expressed in non-ocular tissues

1992 • 251 citations

Mycobacterium tuberculosis 16-kDa Antigen (Hsp16.3) Functions as an Oligomeric Structure in Vitro to Suppress Thermal Aggregation

1996 • 230 citations

[30] Lens α-crystallin: Chaperone-like properties

1998 • 224 citations

Expression of αB-crystallin in Alzheimer's disease

1994 • 221 citations

Immunoreactive αA crystallin in rat non-lenticular tissues detected with a sensitive immunoassay method

1991 • 220 citations

Lens α-crystallin: Function and structure

1999 • 202 citations

The Dynamics of Hsp25 Quaternary Structure

1999 • 166 citations

αB-Crystallin is present in reactive glia in Creutzfeldt-Jakob disease

1992 • 165 citations

Small heat shock protein of Methanococcus jannaschii , a hyperthermophile

1998 • 157 citations

A dynamic quaternary structure of bovine .alpha.-crystallin as indicated from intermolecular exchange of subunits

1990 • 143 citations

Overexpression and abnormal modification of the stress proteins alpha B-crystallin and HSP27 in Alexander disease.

1993 • 128 citations

Coordinate and independent regulation of αB‐crystallin and HSP27 expression in response to physiological stress

1994 • 119 citations

Folding pattern of the α-crystallin domain in αA-crystallin determined by site-directed spin labeling

1999 • 112 citations

Conformational Properties of Substrate Proteins Bound to a Molecular Chaperone α-Crystallin

1996 • 109 citations

NMR spectroscopy of α-crystallin. Insights into the structure, interactions and chaperone action of small heat-shock proteins

1998 • 90 citations

Cryo-EM imaging of the catalytic subunit of the DNA-dependent protein kinase

1998 • 80 citations

Supramolecular structure of the recombinant murine small heat shock protein hsp25

1991 • 75 citations

Probing the structure and interactions of crystallin proteins by NMR spectroscopy

1999 • 66 citations

Structural perturbation of α-crystallin and its chaperone-like activity

1998 • 56 citations

Site-Directed Spin-Labeling Study of the Structure and Subunit Interactions along a Conserved Sequence in the α-Crystallin Domain of Heat-Shock Protein 27. Evidence of a Conserved Subunit Interface

1997 • 55 citations

Multiple sclerosis: an altered immune response or an altered stress response?

1996 • 37 citations

Quaternary structure of bovine α-crystallin: influence of temperature

1998 • 30 citations

QVIEW: Software for Rapid Selection of Particles from Digital Electron Micrographs

1998 • 23 citations

Review: Resolution Issues in Single-Particle Reconstruction

1999 • 13 citations