Immunoglobulin isotypes reveal a predominant role of type 1 immunity in multiple sclerosis

Rating neurologic impairment in multiple sclerosis

1983 • 14,011 citations

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

1986 • 7,504 citations

New diagnostic criteria for multiple sclerosis: Guidelines for research protocols

1983 • 7,404 citations

Functional diversity of helper T lymphocytes

1996 • 4,512 citations

Regulation of antibody isotype secretion by subsets of antigen-specific helper T cells

1988 • 917 citations

CCR5⁺and CXCR3⁺T cells are increased in multiple sclerosis and their ligands MIP-1α and IP-10 are expressed in demyelinating brain lesions

1999 • 839 citations

Axonal pathology in multiple sclerosis: relationship to neurologic disability

1999 • 481 citations

A quantitative analysis of oligodendrocytes in multiple sclerosis lesions

1999 • 445 citations

Interleukin 4 induces synthesis of IgE and IgG4 in human B cells

1989 • 300 citations

Age-related serum immunoglobulin E levels in healthy subjects and in patients with allergic disease

1980 • 269 citations

Cytokine mRNA levels in mononuclear blood cells from patients with multiple sclerosis

1994 • 227 citations

Regulation of human IgG subclass production by cytokines. IFN-gamma and IL-6 act antagonistically in the induction of human IgG1 but additively in the induction of IgG2.

1994 • 227 citations

Elevated interleukin-12 in progressive multiple sclerosis correlates with disease activity and is normalized by pulse cyclophosphamide therapy.

1998 • 222 citations

Étude quantitative des immunoglobulines G et de l'albumine du liquide cephalo rachidien

1972 • 192 citations

A Critical Role for IL-4 in Regulating Disease Severity in Experimental Allergic Encephalomyelitis as Demonstrated in IL-4-Deficient C57BL/6 Mice and BALB/c Mice

1998 • 161 citations

Cytokine-producing cells in experimental autoimmune encephalomyelitis and multiple sclerosis

1995 • 132 citations

Early Autoantibody Responses in Prediabetes Are IgG1 Dominated and Suggest Antigen-Specific Regulation

1999 • 131 citations

Standardization and stability of immunoglobulin E (IgE)

1972 • 119 citations

Immunoglobulin abnormalities in multiple sclerosis

1976 • 107 citations

T lymphocyte differentiation in the periphery

1998 • 103 citations

Cerebrospinal fluid abnormalities in a phase III trial of Avonex® (IFNβ-1a) for relapsing multiple sclerosis1Studies supported by the National Multiple Sclerosis Society (grants RG2019, RG2827); the NINDS (NS26321); and Biogen Inc.1

1999 • 97 citations

IgE and IgG subclass regulation by IL-4 and IFN-gamma in human helminth infections. Assessment by B cell precursor frequencies.

1993 • 84 citations

Cytokine Production and Surface Marker Expression in Acute and Stable Multiple Sclerosis: Altered IL-12 Production and Augmented Signaling Lymphocytic Activation Molecule (SLAM)-Expressing Lymphocytes in Acute Multiple Sclerosis

1998 • 77 citations

Relation between benign course of multiple sclerosis and low-grade humoral immune response in cerebrospinal fluid.

1980 • 75 citations

IgG subclass distribution of antibody responses to protein and polysaccharide mycobacterial antigens in leprosy and tuberculosis patients

1998 • 74 citations

IgG subclasses in Lyme borreliosis: a study of specific IgG subclass distribution in an interferon-gamma-predominated disease.

1998 • 73 citations

Monoclonal antibody-based solid-phase immunoenzymometric assays for quantifying human immunoglobulin G and its subclasses in serum.

1985 • 58 citations

Immunoglobulin isotype production by cycling human B lymphocytes in response to recombinant cytokines and anti-IgM.

1990 • 42 citations

Formulas for the quantitation of intrathecal IgG production

1994 • 39 citations

Allergen‐induced cytokine secretion in relation to atopic symptoms and immunoglobulin E and immunoglobulin G subclass antibody responses

1999 • 38 citations

An improved formula for the judgement of intrathecally produced IgG in the presence of blood brain barrier damage

1989 • 37 citations

Relationships between abnormal IgG index, oligoclonal bands, acute phase reactants and some clinical data in multiple sclerosis

1978 • 36 citations

Identification of IgG subclasses' oligoclonal bands in multiple sclerosis CSF

2009 • 34 citations

Biologic variation of human immunoglobulin concentration. I. Sex-age specific effects on serum levels of IgG, IgA, IgM and IgD.

1980 • 31 citations

IgG Subgroups in Cerebrospinal Fluid in Multiple Sclerosis

1976 • 29 citations

Significant correlation between IL-10 levels and IgG indices in the cerebrospinal fluid of patients with multiple sclerosis

2000 • 25 citations

An automated particle‐counting immunoassay (PACaIA) for serum IgE

1981 • 25 citations

Systemic levels of cytokines and GAD-specific autoantibodies isotypes in Chinese IDDM patients

1999 • 23 citations

Intrathecal synthesis of IgG subclasses in multiple sclerosis and in acquired immunodeficiency syndrome (AIDS)

1991 • 23 citations

Monoclonal antibodies against human IgE. Identification of a determinant restricted to IgE of the lambda light-chain type.

1986 • 18 citations

The Course of Multiple Sclerosis Cases with Extremely High γ-Globulin Values in the Cerebrospinal Fluid

1977 • 17 citations

IgE in the cerebrospinal fluid

1984 • 17 citations

Monoclonal Antibodies against Human IgE

1986 • 12 citations

Quantitation of IgG Subclasses in Cerebrospinal Fluid of Patients with Multiple Sclerosis

1988 • 10 citations