Cerebrospinal fluid abnormalities in a phase III trial of Avonex® (IFNβ-1a) for relapsing multiple sclerosis1Studies supported by the National Multiple Sclerosis Society (grants RG2019, RG2827); the NINDS (NS26321); and Biogen Inc.1

Intramuscular interferon beta‐1a for disease progression in relapsing multiple sclerosis

1996 • 2,410 citations

Interferon beta‐1b is effective in relapsing‐remitting multiple sclerosis

1993 • 2,032 citations

Interferon beta‐1b is effective in relapsing‐remitting multiple sclerosis

1993 • 1,908 citations

Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. I. Clinical results of a multicenter, randomized, double-blind, placebo-controlled trial. The IFNB Multiple Sclerosis Study Group.

1993 • 1,227 citations

Interleukin 12 and tumor necrosis factor alpha are costimulators of interferon gamma production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist.

1993 • 792 citations

Cerebrospinal fluid in the diagnosis of multiple sclerosis: a consensus report.

1994 • 680 citations

Role of interleukin 10 in the B lymphocyte hyperactivity and autoantibody production of human systemic lupus erythematosus.

1995 • 542 citations

Interleukin 10 (IL-10) inhibits the release of proinflammatory cytokines from human polymorphonuclear leukocytes. Evidence for an autocrine role of tumor necrosis factor and IL-1 beta in mediating the production of IL-8 triggered by lipopolysaccharide.

1993 • 504 citations

Interferon β‐1b decreases the migration of T lymphocytes in vitro: Effects on matrix metalloproteinase‐9

1996 • 363 citations

Principles of albumin and IgG analyses in neurological disorders. III. Evaluation of IgG synthesis within the central nervous system in multiple sclerosis

1977 • 331 citations

Interferon beta‐1b inhibits gelatinase secretion and in vitro migration of human T cells: A possible mechanism for treatment efficacy in multiple sclerosis

1996 • 302 citations

Principles of albumin and IgG analyses in neurological disorders. III. Evaluation of IgG synthesis within the central nervous system in multiple sclerosis

1977 • 297 citations

Immunoglobulins in Multiple Sclerosis and Infections of the Nervous System

1971 • 296 citations

In vivo effects of interferon beta-1a on immunosuppressive cytokines in multiple sclerosis

1998 • 220 citations

Increases in soluble VCAM‐1 correlate with a decrease in MRI lesions in multiple sclerosis treated with interferon β‐1b

1997 • 155 citations

A phase III trial of intramuscular recombinant interferon beta as treatment for exacerbating-remitting multiple sclerosis: design and conduct of study and baseline characteristics of patients

1995 • 113 citations

The use and abuse of the cerebrospinal fluid IgG profile in the adult: A practical evaluation

1980 • 100 citations

Multiple sclerosis de novo CNS IgG synthesis

1980 • 71 citations

Regulatory effects of prostaglandin E2 on the growth and differentiation of human B lymphocytes activated through their CD40 antigen.

1994 • 69 citations

Cerebrospinal fluid

1994 • 48 citations

CSF oligoclonal bands, MRI, and the diagnosis of multiple sclerosis

2009 • 42 citations

Relative diagnostic value of cerebrospinal fluid kappa chains in MS

1989 • 36 citations

Treatment of Multiple Sclerosis: Trial Design, Results, and Future Perspectives

1992 • 35 citations

Sensitive competitive‐binding elisas for quantifying free kappa and lambda light chains in cerebrospinal fluid

1991 • 15 citations

IL-10 Stimulates Murine Antigen-Driven Antibody Responsesin Vitroby Regulating Helper Cell Subset Participation

1996 • 14 citations

Treatment of Multiple Sclerosis with Interferons

1992 • 13 citations

Intrathecal IgG Synthesis and IgG Index after Intensive and Chronic Immunosuppressive Treatment of Multiple Sclerosis

1984 • 6 citations