Generation and Elimination of 8-Oxo-7,8-dihydro-2'-deoxyguanosine 5'-Triphosphate, a Mutagenic Substrate for DNA Synthesis, in Human Cells

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG

1991 • 2,172 citations

8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G-T and A-C substitutions.

1992 • 1,830 citations

Formation of 8-hydroxyguanine moiety in cellular DNA by agents producing oxygen radicals and evidence for its repair

1986 • 933 citations

MutT protein specifically hydrolyses a potent mutagenic substrate for DNA synthesis

1992 • 875 citations

Urinary 8-hydroxy-2'-deoxyguanosine as a biological marker of in vivo oxidative DNA damage.

1989 • 733 citations

Endogenous mutagens and the causes of aging and cancer

1991 • 725 citations

The GO system protects organisms from the mutagenic effect of the spontaneous lesion 8-hydroxyguanine (7,8-dihydro-8-oxoguanine)

1992 • 688 citations

Substrate specificity of the Escherichia coli Fpg protein formamidopyrimidine-DNA glycosylase: excision of purine lesions in DNA produced by ionizing radiation or photosensitization

1992 • 597 citations

Cloning and expression of cDNA for a human enzyme that hydrolyzes 8-oxo-dGTP, a mutagenic substrate for DNA synthesis.

1993 • 437 citations

Single-stranded shuttle phagemid for mutagenesis studies in mammalian cells: 8-oxoguanine in DNA induces targeted G.C-->T.A transversions in simian kidney cells.

1993 • 407 citations

The mutY gene: a mutator locus in Escherichia coli that generates G.C----T.A transversions.

1988 • 343 citations

Hydrolytic elimination of a mutagenic nucleotide, 8-oxodGTP, by human 18-kilodalton protein: sanitization of nucleotide pool.

1992 • 310 citations

The unusual mutagenic specificity of an E. Coli mutator gene.

1966 • 271 citations

Transient accumulation of Okazaki fragments as a result of uracil incorporation into nascent DNA.

1977 • 265 citations

Modification of DNA bases in mammalian chromatin by radiation-generated free radicals

1990 • 255 citations

Escherichia coli mutY gene encodes an adenine glycosylase active on G-A mispairs.

1989 • 225 citations

MutM, a protein that prevents G C→T A transversions, is formamidopyrimidine-DNA glycosylase

1991 • 210 citations

Erythrocytic Nucleoside Diphosphokinase

1966 • 190 citations

mutM, a second mutator locus in Escherichia coli that generates G.C----T.A transversions

1988 • 180 citations

Repair of DNA containing the oxidatively-damaged base, 8-oxoguanine

1993 • 161 citations

Escherichia coli mutY gene product is required for specific A-G----C.G mismatch correction.

1988 • 152 citations

An endonuclease activity of Escherichia coli that specifically removes 8-hydroxyguanine residues from DNA

1991 • 149 citations

Repair of 8-hydroxyguanine in DNA by mammalian N-methylpurine-DNA glycosylase.

1993 • 136 citations

Interrelations between substrate cycles and de novo synthesis of pyrimidine deoxyribonucleoside triphosphates in 3T6 cells.

1986 • 80 citations

Two nicking enzyme systems specific for mismatch-containing DNA in nuclear extracts from human cells.

1991 • 73 citations

Adenosine Triphosphate: Guanosine Monophosphate Phosphotransferase

1965 • 71 citations

Evidence for the involvement of substrate cycles in the regulation of deoxyribonucleoside triphosphate pools in 3T6 cells.

1985 • 67 citations

Purification and Properties of Guanylate Kinase from Escherichia coli

1966 • 53 citations

Cytoplasmic 5'(3')-nucleotidase from human placenta.

1990 • 47 citations

Deficiency of 8-hydroxyguanine dna endonuclease activity and accumulation of the 8-hydroxyguanine in mutator mutant (mutM) of Escherichia coli

1992 • 42 citations

Purification of the MutX protein of Streptococcus pneumoniae, a homologue of Escherichia coli MutT. Identification of a novel catalytic domain for nucleoside triphosphate pyrophosphohydrolase activity.

1994 • 39 citations

Sequence and characterization of mutT from Proteus vulgaris

1993 • 38 citations

Repair of deaminated cytosine residues of DNA: Biological significance of the absence of uracil from DNA

1978 • 7 citations

Deoxyribonucleotide metabolism in hydroxyurea‐resistant V79 hamster cells

1991 • 6 citations

Purification and some particular kinetic properties of rat spleen cytosolic deoxynucleotidase

1991 • 3 citations