The impact of CYP2E1 on the development of alcoholic liver disease as studied in a transgenic mouse model

Principal component analysis

1987 • 10,338 citations

Principal Component Analysis

1988 • 8,927 citations

Principal Component Analysis

1986 • 7,864 citations

Methods in Molecular Biology

2008 • 1,605 citations

Alcohol, oxidative stress and free radical damage

2006 • 1,140 citations

Oxidative stress-related molecules and liver fibrosis

2001 • 768 citations

Essential role of tumor necrosis factor α in alcohol-induced liver injury in mice

1999 • 704 citations

CYP2E1 and oxidative liver injury by alcohol

2007 • 697 citations

Alcoholic fatty liver: its pathogenesis and mechanism of progression to inflammation and fibrosis

2004 • 656 citations

Robust estimators for expression analysis

2002 • 600 citations

Rat liver microsomal NADPH-supported oxidase activity and lipid peroxidation dependent on ethanol-inducible cytochrome P-450 (P-450IIE1)

1989 • 527 citations

Oxidants and antioxidants in alcohol-induced liver disease

2003 • 483 citations

Ethanol, oxidative stress, and cytokine-induced liver cell injury

2002 • 467 citations

Metformin Inhibits Hepatic Gluconeogenesis Through AMP-Activated Protein Kinase–Dependent Regulation of the Orphan Nuclear Receptor SHP

2007 • 408 citations

Clustering of Hepatotoxins Based on Mechanism of Toxicity Using Gene Expression Profiles

2001 • 384 citations

Human drug metabolising cytochrome P450 enzymes: properties and polymorphisms

2004 • 344 citations

Ethanol-induced liver fibrosis in rats fed high fat diet

1986 • 279 citations

Stimulation and proliferation of primary rat hepatic stellate cells by cytochrome P450 2E1-derived reactive oxygen species

2002 • 260 citations

Principal Component Analysis

2009 • 233 citations

Ethanol-inducible cytochrome P4502E1: Genetic polymorphism, regulation, and possible role in the etiology of alcohol-induced liver disease

1993 • 232 citations

Gene Expression Profile of Adipocyte Differentiation and Its Regulation by Peroxisome Proliferator-Activated Receptor-γ Agonists

2002 • 178 citations

Inhibition of Ethanol-Induced Liver Disease in the Intragastric Feeding Rat Model by Chlormethiazole

2000 • 165 citations

Modulation of experimental alcohol-induced liver disease by cytochrome P450 2E1 inhibitors

1995 • 164 citations

Oxidative stress-induced apoptosis is mediated by ERK1/2 phosphorylation

2003 • 158 citations

Production of a cytochrome P450 2E1 transgenic mouse and initial evaluation of alcoholic liver damage

2002 • 153 citations

Cytokeratin-18 Is a Useful Serum Biomarker for Early Determination of Response of Breast Carcinomas to Chemotherapy

2007 • 146 citations

ERK1/2 and Egr-1 contribute to increased TNF-α production in rat Kupffer cells after chronic ethanol feeding

2002 • 137 citations

Induction of catalase, alpha, and microsomal glutathione S-transferase in CYP2E1 overexpressing HepG2 cells and protection against short-term oxidative stress

2001 • 137 citations

Kupffer Cell Sensitization by Alcohol Involves Increased Permeability to Gut-Derived Endotoxin

2001 • 115 citations

The Effect of Ethanol-Induced Cytochrome p4502E1 on the Inhibition of Proteasome Activity by Alcohol

2000 • 107 citations

Kupffer Cell Sensitization by Alcohol Involves Increased Permeability to Gut‐Derived Endotoxin

2001 • 106 citations

Cellular Signaling Mechanisms in Alcohol-Induced Liver Damage

2004 • 103 citations

JunD Regulates Transcription of the Tissue Inhibitor of Metalloproteinases-1 and Interleukin-6 Genes in Activated Hepatic Stellate Cells

2001 • 97 citations

Hydroxyethyl radicals in ethanol hepatotoxicity

1999 • 97 citations

CYP2E1 induced by ethanol causes oxidative stress, proteasome inhibition and cytokeratin aggresome (Mallory body-like) formation

2006 • 88 citations

Increased cytochromeP-450 2E1 expression sensitizes hepatocytes to c-Jun-mediated cell death from TNF-α

2002 • 86 citations

Up-regulation of CD14 in Liver Caused by Acute Ethanol Involves Oxidant-dependent AP-1 Pathway

2003 • 71 citations

Keratin 8 overexpression promotes mouse Mallory body formation

2005 • 63 citations

Metabolism of human cytochrome P450 marker substrates in mouse: a strain and gender comparison

2004 • 62 citations

Cytochrome P4502E1 primes macrophages to increase TNF-α production in response to lipopolysaccharide

2005 • 62 citations

Serum cytokeratins in alcoholic liver disease: contrasting levels of cytokeratin-18 and cytokeratin-19

2006 • 54 citations

Development and Properties of HepG2 Cells That Constitutively Express CYP2E1

2008 • 49 citations

Modulation of experimental alcohol-induced liver disease by cytochrome P450 2E1 inhibitors*1

1995 • 48 citations

Continuous Autotropic Signaling by Membrane-expressed Tumor Necrosis Factor

1999 • 47 citations

Ethanol-induced alterations in messenger RNA levels correlate with glandular content of pancreatic enzymes.

1995 • 45 citations

Adenovirus-Mediated Expression of CYP2E1 Produces Liver Toxicity in Mice

2006 • 42 citations

Alcohol‐Induced Expression of the CD14 Endotoxin Receptor Protein in Rat Kupffer Cells

1997 • 42 citations

SHORT-TERM ETHANOL EXPOSURE INCREASES THE EXPRESSION OF KUPFFER CELL CD14 RECEPTOR AND LIPOPOLYSACCHARIDE BINDING PROTEIN IN RAT LIVER

1999 • 39 citations

Cytochrome P450 2E1 responsiveness in the promoter of glutamate-cysteine ligase catalytic subunit

2003 • 32 citations

Effect of ethanol on the expression of hepatic glutathione S-transferase: an in vivo/in vitro study

2000 • 23 citations

ROLE OF MOUSE CYP2E1 IN THEO-HYDROXYLATION OFP-NITROPHENOL: COMPARISON OF ACTIVITIES IN HEPATIC MICROSOMES FROMCYP2E1(-/-) AND WILD-TYPE MICE

2004 • 15 citations

Cytokeratin markers in patients with prostatic diseases.

1999 • 3 citations

Effect of a new hepatoprotective agent, YH-439, on the hepatobiliary transport of organic cations (OCS): Selective inhibition of sinusoidal OCs uptake without influencing glucose uptake and canalicular OCs excretion

2005 • 1 citations