Development and Properties of HepG2 Cells That Constitutively Express CYP2E1

Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects

1991 • 1,173 citations

Oxidative and reductive metabolism by cytochrome P450 2E1

1992 • 557 citations

Role of cytochromes P450 in chemical toxicity and oxidative stress: studies with CYP2E1

2004 • 538 citations

Rat liver microsomal NADPH-supported oxidase activity and lipid peroxidation dependent on ethanol-inducible cytochrome P-450 (P-450IIE1)

1989 • 527 citations

Oxidative Stress, Toxicology, and Pharmacology of CYP2E1

2004 • 500 citations

Current concepts in the pathogenesis of alcoholic liver injury

2001 • 384 citations

Cytochrome P450IIe1: Roles in Nitrosamine Metabolism and Mechanisms of Regulation

1990 • 361 citations

Markedly Enhanced Cytochrome P450 2E1 Induction and Lipid Peroxidation Is Associated with Severe Liver Injury in Fish Oil—Ethanol‐Fed Rats

1994 • 265 citations

Stable expression of human cytochrome P4502E1 in HepG2 cells: Characterization of catalytic activities and production of reactive oxygen intermediates

1993 • 244 citations

Role of cytochrome P-450 2E1 in ethanol-, carbon tetrachloride— and iron-dependent microsomal lipid peroxidation

1992 • 212 citations

Cytochrome P450 2E1: its clinical and toxicological role

2000 • 200 citations

Cytotoxicity and Apoptosis Produced by Arachidonic Acid in Hep G2 Cells Overexpressing Human Cytochrome P4502E1

1997 • 198 citations

Ethanol Cytotoxicity to a Transfected HepG2 Cell Line Expressing Human Cytochrome P4502E1

1996 • 197 citations

Introduction—serial review: alcohol, oxidative stress and cell injury

2001 • 185 citations

Fish Oil, Alcohol, and Liver Pathology: Role of Cytochrome P450 2E1

1994 • 178 citations

Cytotoxicity of acetaminophen in human cytochrome P4502E1-transfected HepG2 cells.

1995 • 165 citations

Inhibition of Ethanol-Induced Liver Disease in the Intragastric Feeding Rat Model by Chlormethiazole

2000 • 165 citations

Gadolinium Chloride Blocks Alcohol-Dependent Liver Toxicity in Rats Treated Chronically with Intragastric Alcohol Despite the Induction of CYP2E1

1997 • 162 citations

Cytotoxicity and Apoptosis Produced by Cytochrome P450 2E1 in Hep G2 Cells

1998 • 162 citations

CYP2E1 is not involved in early alcohol-induced liver injury

1999 • 160 citations

Production of a cytochrome P450 2E1 transgenic mouse and initial evaluation of alcoholic liver damage

2002 • 153 citations

Cytochrome P450 CYP2E1, but not nicotinamide adenine dinucleotide phosphate oxidase, is required for ethanol-induced oxidative DNA damage in rodent liver

2005 • 151 citations

CYP2E1: Biochemistry, Toxicology, Regulation and Function in Ethanol-Induced Liver Injury

2003 • 150 citations

Ethanol‐Induced Apoptosis to Stable HepG2 Cell Lines Expressing Human Cytochrome P‐4502E1

1999 • 112 citations

Oxidative Stress and Cytotoxicity Induced by Ferric-Nitrilotriacetate in HepG2 Cells That Express Cytochrome P450 2E1

1998 • 108 citations

The Effect of Ethanol-Induced Cytochrome p4502E1 on the Inhibition of Proteasome Activity by Alcohol

2000 • 107 citations

Removal of Glutathione Produces Apoptosis and Necrosis in HepG2 Cells Overexpressing CYP2E1

2001 • 77 citations

Inactivation and degradation of human cytochrome P4502E1 by CCl4 in a transfected HepG2 cell line.

1995 • 60 citations

CYP2E1-dependent oxidative stress and toxicity: role in ethanol-induced liver injury

2005 • 58 citations

The CYP inhibitor 1-aminobenzotriazole does not prevent oxidative stress associated with alcohol-induced liver injury in rats and mice

2003 • 29 citations