Eotaxin and asthma

Chemokines

2000 • 3,773 citations

Interleukin-13: Central Mediator of Allergic Asthma

1998 • 2,642 citations

International union of pharmacology. XXII. Nomenclature for chemokine receptors.

2000 • 1,771 citations

Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production

1999 • 1,715 citations

Selective Expression of the Eotaxin Receptor CCR3 by Human T Helper 2 Cells

1997 • 1,073 citations

Eotaxin: a potent eosinophil chemoattractant cytokine detected in a guinea pig model of allergic airways inflammation.

1994 • 822 citations

Cloning of the human eosinophil chemoattractant, eotaxin. Expression, receptor binding, and functional properties suggest a mechanism for the selective recruitment of eosinophils.

1996 • 719 citations

Cooperation between interleukin-5 and the chemokine eotaxin to induce eosinophil accumulation in vivo.

1995 • 657 citations

Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils.

1996 • 626 citations

The Coordinated Action of CC Chemokines in the Lung Orchestrates Allergic Inflammation and Airway Hyperresponsiveness

1998 • 546 citations

Targeted Disruption of the Chemokine Eotaxin Partially Reduces Antigen-induced Tissue Eosinophilia

1997 • 537 citations

High expression of the chemokine receptor CCR3 in human blood basophils. Role in activation by eotaxin, MCP-4, and other chemokines.

1997 • 489 citations

Chemokine receptor usage by human eosinophils. The importance of CCR3 demonstrated using an antagonistic monoclonal antibody.

1997 • 474 citations

A binding pocket for a small molecule inhibitor of HIV-1 entry within the transmembrane helices of CCR5

2000 • 430 citations

Enhanced expression of eotaxin and CCR3 mRNA and protein in atopic asthma. Association with airway hyperresponsiveness and predominant co‐localization of eotaxin mRNA to bronchial epithelial and endothelial cells

1997 • 429 citations

Eosinophil Chemotactic Chemokines (Eotaxin, Eotaxin-2, RANTES, Monocyte Chemoattractant Protein-3 (MCP-3), and MCP-4), and C-C Chemokine Receptor 3 Expression in Bronchial Biopsies from Atopic and Nonatopic (Intrinsic) Asthmatics

1999 • 415 citations

Eotaxin-2, a Novel CC Chemokine that Is Selective for the Chemokine Receptor CCR3, and Acts Like Eotaxin on Human Eosinophil and Basophil Leukocytes

1997 • 413 citations

Effects of Th2 Cytokines on Chemokine Expression in the Lung: IL-13 Potently Induces Eotaxin Expression by Airway Epithelial Cells

1999 • 397 citations

Murine eotaxin: an eosinophil chemoattractant inducible in endothelial cells and in interleukin 4-induced tumor suppression.

1995 • 351 citations

Asthma and Rhinitis

1995 • 326 citations

Cc Chemokine Receptor (Ccr)3/Eotaxin Is Followed by Ccr4/Monocyte-Derived Chemokine in Mediating Pulmonary T Helper Lymphocyte Type 2 Recruitment after Serial Antigen Challenge in Vivo

2000 • 309 citations

The Ligands of CXC Chemokine Receptor 3, I-TAC, Mig, and IP10, Are Natural Antagonists for CCR3

2001 • 307 citations

Eotaxin Induces a Rapid Release of Eosinophils and Their Progenitors From the Bone Marrow

1998 • 283 citations

Eotaxin induces degranulation and chemotaxis of eosinophils through the activation of ERK2 and p38 mitogen-activated protein kinases

2000 • 280 citations

A Novel Human CC Chemokine, Eotaxin-3, Which Is Expressed in IL-4-Stimulated Vascular Endothelial Cells, Exhibits Potent Activity Toward Eosinophils

1999 • 269 citations

Kinetics of Eotaxin Generation and Its Relationship to Eosinophil Accumulation in Allergic Airways Disease: Analysis in a Guinea Pig Model In Vivo

1997 • 255 citations

Identification of the Binding Site for a Novel Class of CCR2b Chemokine Receptor Antagonists

2000 • 250 citations

Molecular and Functional Characterization of Two Novel Human C-C Chemokines as Inhibitors of Two Distinct Classes of Myeloid Progenitors

1997 • 239 citations

Th1- and Th2-Type Cytokines Regulate the Expression and Production of Eotaxin and RANTES by Human Lung Fibroblasts

1999 • 235 citations

Activation of eotaxin gene transcription by NF-kappa B and STAT6 in human airway epithelial cells.

1999 • 235 citations

A Small Molecule Antagonist of Chemokine Receptors CCR1 and CCR3

2000 • 218 citations

Binding and Functional Properties of Recombinant and Endogenous CXCR3 Chemokine Receptors

1998 • 212 citations

Molecular Cloning of a Novel Human CC Chemokine (Eotaxin-3) That Is a Functional Ligand of CC Chemokine Receptor 3

1999 • 208 citations

Mechanisms of Acute Eosinophil Mobilization from the Bone Marrow Stimulated by Interleukin 5: The Role of Specific Adhesion Molecules and Phosphatidylinositol 3-Kinase

1998 • 204 citations

The Effect of IL-5 and Eotaxin Expression in the Lung on Eosinophil Trafficking and Degranulation and the Induction of Bronchial Hyperreactivity

2000 • 182 citations

Murine Eotaxin-2: A Constitutive Eosinophil Chemokine Induced by Allergen Challenge and IL-4 Overexpression

2000 • 173 citations

Cloning and functional characterization of a novel human CC chemokine that binds to the CCR3 receptor and activates human eosinophils

1997 • 163 citations

Eotaxin: Cloning of an Eosinophil Chemoattractant Cytokine and Increased mRNA Expression in Allergen-Challenged Guinea-Pig Lungs

1994 • 156 citations

Temporal Role of Chemokines in a Murine Model of Cockroach Allergen-Induced Airway Hyperreactivity and Eosinophilia

1998 • 156 citations

Enhanced Pulmonary Allergic Responses toAspergillusin CCR2−/− Mice

2000 • 150 citations

Activation of Mitogen-Activated Protein Kinase Regulates Eotaxin-Induced Eosinophil Migration

1999 • 142 citations

T cell-dependent regulation of eotaxin in antigen-induced pulmonary eosinophila.

1996 • 126 citations

Eotaxin and Impaired Lung Function in Asthma

1999 • 121 citations

Differential Regulation of Epithelial-Derived C-C Chemokine Expression by IL-4 and the Glucocorticoid Budesonide

1999 • 118 citations

Identification of Potent, Selective Non-peptide CC Chemokine Receptor-3 Antagonist That Inhibits Eotaxin-, Eotaxin-2-, and Monocyte Chemotactic Protein-4-induced Eosinophil Migration

2000 • 117 citations

Airway Remodeling Is Absent in CCR1−/− Mice During Chronic Fungal Allergic Airway Disease

2000 • 116 citations

Elevated plasma eotaxin levels in patients with acute asthma

1999 • 99 citations

Antigen-Induced Eosinophilic Lung Inflammation Develops in Mice Deficient in Chemokine Eotaxin

1998 • 94 citations

Identification of a Mouse Eosinophil Receptor for the CC Chemokine Eotaxin

1996 • 86 citations

Genomic Organization, Sequence, and Transcriptional Regulation of the Human Eotaxin Gene

1997 • 85 citations

Cloning and Characterization of the Guinea Pig Eosinophil Eotaxin Receptor, C-C Chemokine Receptor-3: Blockade Using a Monoclonal Antibody In Vivo

1998 • 74 citations

Eotaxin in induced sputum of asthmatics: relationship with eosinophils and eosinophil cationic protein in sputum

2000 • 71 citations

Characterization of airway inflammation after repeated exposures to occupational agents

2000 • 70 citations

Opportunities for novel therapeutic agents acting at chemokine receptors

1999 • 67 citations

Eotaxin protein and gene expression in guinea-pig lungs: constitutive expression and upregulation after allergen challenge

1997 • 66 citations

Increased mature and immature CCR3 messenger RNA+ eosinophils in bone marrow from patients with atopic asthma compared with atopic and nonatopic control subjects

1999 • 50 citations

Increases in eotaxin‐positive cells in induced sputum from atopic asthmatic subjects after inhalational allergen challenge

1999 • 38 citations

Deleted Work

1955 • 0 citations