Topoisomerase I mutants: the gene on pBR322 that encodes resistance to tetracycline affects plasmid DNA supercoiling.

The pUC plasmids, an M13mp7-derived system for insertion mutagenesis and sequencing with synthetic universal primers

1982 • 6,153 citations

Complete Nucleotide Sequence of the Escherichia coli Plasmid pBR322

1979 • 1,807 citations

DNA gyrase: an enzyme that introduces superhelical turns into DNA.

1976 • 1,175 citations

DNA Topoisomerases

1981 • 977 citations

Nalidixic acid resistance: A second genetic character involved in DNA gyrase activity

1977 • 828 citations

Mechanism of action of nalidixic acid: Purification of Escherichia coli nalA gene product and its relationship to DNA gyrase and a novel nicking-closing enzyme

1977 • 777 citations

Interaction between DNA and an Escherichia coli protein ω

1971 • 749 citations

Regulation of the genes for E. coli DNA gyrase: Homeostatic control of DNA supercoiling

1983 • 458 citations

Escherichia coli DNA topoisomerase I mutants have compensatory mutations in DNA gyrase genes

1982 • 450 citations

Escherichia coli DNA topoisomerase I mutants: Increased supercoiling is corrected by mutations near gyrase genes

1982 • 376 citations

DNA Topoisomerases: Enzymes That Control DNA Conformation

1985 • 337 citations

Biology of bacterial deoxyribonucleic acid topoisomerases

1984 • 325 citations

Revised sequence of the tetracycline-resistance gene of pBR322

1983 • 287 citations

Mutations in the gene coding for Escherichia coli DNA topoisomerase I affect transcription and transposition.

1981 • 284 citations

A topological model for transcription based on unwinding angle analysis of E. coli RNA polymerase binary, initiation and ternary complexes

1982 • 264 citations

DNA Supercoiling and Its Effects on DNA Structure and Function

1983 • 243 citations

Thermodynamic properties of superhelical DNAs

1975 • 229 citations

Precise location of two promoters for the beta-lactamase gene of pBR322. S1 mapping of ribonucleic acid isolated from Escherichia coli or synthesized in vitro.

1982 • 210 citations

DNA gyrase: purification and catalytic properties of a fragment of gyrase B protein.

1979 • 158 citations

Isolation and characterisation of a strain carrying a conditional lethal mutation in the cou gene of Escherichia coli K12

1979 • 157 citations

DNA topoisomerase I mutants

1985 • 131 citations

Regulation of theEscherichia coliDNA topoisomerase I gene by DNA supercolling

1985 • 131 citations

The genetic control of DNA supercoiling in Salmonella typhimurium.

1984 • 117 citations

Sites of reaction of Escherichia coli DNA gyrase on pBR322 in vivo as revealed by oxolinic acid-induced plasmid linearization

1985 • 117 citations

Genetic analysis of mutations that compensate for loss of Escherichia coli DNA topoisomerase I

1985 • 106 citations

Escherichia coli Type-1 Topoisomerases: Identification, Mechanism, and Role in Recombination

1983 • 100 citations

Regulatory regions of ColE1 that are involved in determination of plasmid copy number.

1983 • 70 citations

Characterizing wild-type and mutant promoters of the tetracycline resistance gene in pBR313

1979 • 70 citations

DNA gyrase is a host factor required for transposition of Tn5

1982 • 69 citations

Regulation of DNA Supercoiling in Escherichia coli

1983 • 65 citations

Lambda transducing phages for the nalA gene of Escherichia coli and conditional lethal nalA mutations

1978 • 40 citations

Mapping of DNA gyrase cleavage sites in vivo oxolinic acid induced cleavages in plasmid pBR322

1985 • 40 citations

Nucleotide sequence of the gene, protein purification and characterization of the pSC101-encoded tetracycline resistance-gene-repressor

1984 • 28 citations

DNA supercoiling of recombinant plasmids in mammalian cells.

1986 • 13 citations

Sequence rearrangements may alter the in vivo superhelicity of recombinant plasmids

1986 • 3 citations