Current Therapy for Multiple Myeloma

Cancer Statistics, 2002

2002 • 2,954 citations

Antitumor Activity of Thalidomide in Refractory Multiple Myeloma

1999 • 2,565 citations

Thalidomide is an inhibitor of angiogenesis.

1994 • 2,460 citations

Clinical Applications of Research on Angiogenesis

1995 • 2,300 citations

Multiple myeloma

2000 • 2,210 citations

A PROSPECTIVE, RANDOMIZED TRIAL OF AUTOLOGOUS BONE MARROW TRANSPLANTATION AND CHEMOTHERAPY IN MULTIPLE MYELOMA

2013 • 2,176 citations

Efficacy of Pamidronate in Reducing Skeletal Events in Patients with Advanced Multiple Myeloma

1996 • 1,091 citations

Zoledronic acid versus pamidronate in the treatment of skeletal metastases in patients with breast cancer or osteolytic lesions of multiple myeloma: a phase III, double-blind, comparative trial.

2001 • 894 citations

Zoledronic Acid Is Superior to Pamidronate in the Treatment of Hypercalcemia of Malignancy: A Pooled Analysis of Two Randomized, Controlled Clinical Trials

2001 • 825 citations

Long-term pamidronate treatment of advanced multiple myeloma patients reduces skeletal events. Myeloma Aredia Study Group.

1998 • 666 citations

Superiority of Tandem Autologous Transplantation Over Standard Therapy for Previously Untreated Multiple Myeloma

1997 • 576 citations

Comparison of 200 mg/m2 melphalan and 8 Gy total body irradiation plus 140 mg/m2 melphalan as conditioning regimens for peripheral blood stem cell transplantation in patients with newly diagnosed multiple myeloma: final analysis of the Intergroupe Francophone du Myelome 9502 randomized trial

2002 • 562 citations

Extended survival in advanced and refractory multiple myeloma after single-agent thalidomide: identification of prognostic factors in a phase 2 study of 169 patients

2001 • 553 citations

High-Dose Therapy and Autologous Peripheral Blood Stem Cell Transplantation in Multiple Myeloma: Up-front or Rescue Treatment? Results of a Multicenter Sequential Randomized Clinical Trial

1998 • 553 citations

Zoledronic acid reduces skeletal-related events in patients with osteolytic metastases

2001 • 529 citations

Total Therapy With Tandem Transplants for Newly Diagnosed Multiple Myeloma

1999 • 499 citations

Increased risk of deep-vein thrombosis in patients with multiple myeloma receiving thalidomide and chemotherapy

2001 • 497 citations

Combination chemotherapy versus melphalan plus prednisone as treatment for multiple myeloma: An overview of 6,633 patients from 27 randomized trials

1998 • 486 citations

Smoldering Multiple Myeloma

1980 • 446 citations

Combination chemotherapy versus melphalan plus prednisone as treatment for multiple myeloma: an overview of 6,633 patients from 27 randomized trials. Myeloma Trialists' Collaborative Group.

1998 • 429 citations

The Treatment of Multiple Myeloma

1994 • 409 citations

Maintenance Treatment with Recombinant Interferon Alfa-2b in Patients with Multiple Myeloma Responding to Conventional Induction Chemotherapy

1990 • 389 citations

Multiple Myeloma

1997 • 389 citations

Primary dexamethasone treatment of multiple myeloma

1992 • 351 citations

Results of high-dose therapy for 1000 patients with multiple myeloma: durable complete remissions and superior survival in the absence of chromosome 13 abnormalities

2000 • 333 citations

Allogeneic marrow transplantation for multiple myeloma: an analysis of risk factors on outcome

1996 • 332 citations

Prognostic value of bone marrow angiogenesis in multiple myeloma.

2000 • 321 citations

VAD‐based regimens as primary treatment for multiple myeloma

1990 • 320 citations

Donor Leukocyte Infusions Are Effective in Relapsed Multiple Myeloma After Allogeneic Bone Marrow Transplantation

1997 • 315 citations

Maintenance therapy with alternate-day prednisone improves survival in multiple myeloma patients

2002 • 246 citations

Age Is Not a Prognostic Variable With Autotransplants for Multiple Myeloma

1999 • 242 citations

Treatment of Renal Failure Associated With Multiple Myeloma

1990 • 241 citations

Randomised trial of intravenous immunoglobulin as prophylaxis against infection in plateau-phase multiple myeloma

1994 • 238 citations

[Renal failure in multiple myeloma].

1986 • 221 citations

Initial versus deferred melphalan‐prednisone therapy for asymptomatic multiple myeloma stage I — A randomized study

1993 • 219 citations

S.T.E.P.S.™: A comprehensive program for controlling and monitoring access to thalidomide

1999 • 215 citations

Interferon as therapy for multiple myeloma: an individual patient data overview of 24 randomized trials and 4012 patients

2001 • 212 citations

Purging of Autologous Peripheral-Blood Stem Cells Using CD34 Selection Does Not Improve Overall or Progression-Free Survival After High-Dose Chemotherapy for Multiple Myeloma: Results of a Multicenter Randomized Controlled Trial

2001 • 201 citations

Thalidomide in the Treatment of Relapsed Multiple Myeloma

2000 • 188 citations

Improved Outcome of Allogeneic Transplantation in High-Risk Multiple Myeloma Patients After Nonmyeloablative Conditioning

2002 • 186 citations

High-dose therapy for refractory multiple myeloma: improved prognosis with better supportive care and double transplants

1994 • 172 citations

Bone marrow angiogenesis in patients achieving complete response after stem cell transplantation for multiple myeloma

1999 • 156 citations

Combination chemotherapy, glucocorticoids, and interferon alfa in the treatment of multiple myeloma: a Southwest Oncology Group study.

1994 • 139 citations

Bone marrow of patients with active multiple myeloma: Angiogenesis and plasma cell adhesion molecules LFA-1, VLA-4, LAM-1, and CD44

1995 • 139 citations

A review of angiogenesis and antiangiogenic therapy with thalidomide in multiple myeloma

2000 • 124 citations

Factors influencing collection of peripheral blood progenitor cells following high‐dose cyclophosphamide and granulocyte colony‐stimulating factor in patients with multiple myeloma

1997 • 112 citations

Myeloma : biology and management

1995 • 104 citations

Randomized trial of interferon maintenance in multiple myeloma: a study of the National Cancer Institute of Canada Clinical Trials Group.

1995 • 102 citations

Comparison of melphalan and prednisone with vincristine, carmustine, melphalan, cyclophosphamide, and prednisone in the treatment of multiple myeloma

1997 • 100 citations

Interferon alfa‐2b versus no maintenance therapy during the plateau phase in multiple myeloma: a randomized study

1995 • 96 citations

Interferon-alpha for induction and maintenance in multiple myeloma: Results of two multicenter randomized trials and summary of other studies

1995 • 90 citations

Neoplastic Diseases of the Blood

1996 • 85 citations

High-Dose Melphalan With Autotransplantation for Refractory Multiple Myeloma: Results of a Southwest Oncology Group Phase II Trial

1999 • 81 citations

A comparison of polychemotherapy and melphalan/prednisone for primary remission induction, and interferon-alpha for maintenance treatment, in multiple myeloma. A prospective trial of the German Myeloma Treatment Group

1995 • 75 citations

A prognostic index for multiple myeloma

1996 • 75 citations

Autologous stem cell transplantation for relapsed and primary refractory myeloma

1999 • 71 citations

The role of autologous hematopoietic stem cell transplantation in multiple myeloma.

1997 • 66 citations

High-dose busulfan and cyclophosphamide are an effective conditioning regimen for allogeneic bone marrow transplantation in chemosensitive multiple myeloma

1998 • 65 citations

Interferon versus interferon plus prednisone remission maintenance therapy for multiple myeloma: a Southwest Oncology Group Study.

1998 • 62 citations

Recombinant Human Erythropoietin in the Treatment of Multiple Myeloma-Associated Anemia

1997 • 57 citations

Treatment of cancer-associated hypercalcemia. Double-blind comparison of rapid and slow intravenous infusion regimens of pamidronate disodium and saline alone

1994 • 55 citations

The role of radiotherapy

1980 • 55 citations

Clinical results of recombinant erythropoietin in transfusion‐dependent patients with refractory multiple myeloma: role of cytokines and monitoring of erythropoiesis

1997 • 54 citations

Renal failure in multiple myeloma. Pathogenesis and prognostic implications

1990 • 53 citations

Multiple Myeloma in Naproxen-Induced Acute Renal Failure

1987 • 51 citations

Treatment of Cancer-Associated Hypercalcemia

1994 • 41 citations

Multiple Myeloma

2001 • 36 citations

Antitumor Activity of Thalidomide in Refractory Multiple Myeloma

2000 • 36 citations

Successful mobilization of peripheral blood stem cells in heavily pretreated myeloma patients with G-CSF alone

1998 • 34 citations

Current status of thalidomide in the treatment of cancer.

2001 • 33 citations

Biology and therapy of multiple myeloma in 1996.

1997 • 33 citations

A phase 1 study of oral CC5013, an immunomodulatory thalidomide (Thal) derivative, in patients with relapsed and refractory multiple myeloma (MM).

2001 • 29 citations

Intensive treatment strategies in multiple myeloma.

1997 • 24 citations

Hematopoietic Stem Cell Transplants for Multiple Myeloma

1996 • 21 citations

Interferon in the Treatment of Multiple Myeloma

1998 • 20 citations

Allogeneic bone marrow transplantation for the treatment of multiple myeloma: An overview of published reports

1996 • 19 citations

Allogeneic Bone Marrow Transplantation in Multiple Myeloma

1992 • 18 citations

Acute renal failure precipitated by non-steroidal anti-inflammatory drugs (NSAIDs) in multiple myeloma

1998 • 17 citations

Refractory and Relapsing Multiple Myeloma Treated by Blood Stem Cell Transplantation

1995 • 17 citations

Pneumocystis carinii Pneumonia in HIV-negative patients with haematologic disease

1997 • 9 citations