Interferon in the Treatment of Multiple Myeloma

Cytokine therapeutics: lessons from interferonalpha.

1994 • 703 citations

Maintenance Treatment with Recombinant Interferon Alfa-2b in Patients with Multiple Myeloma Responding to Conventional Induction Chemotherapy

1990 • 389 citations

PRIMARY SEX-RATIO AND SIZE OF FAMILY

1970 • 366 citations

Antineoplastic activity of the combination of interferon and cytotoxic agents against experimental and human malignancies: a review.

1990 • 351 citations

Cardiotoxicity of Interferon*

1991 • 218 citations

Autologous stem cell transplantation after first remission induction treatment in multiple myeloma: a report of the French Registry on autologous transplantation in multiple myeloma

1995 • 168 citations

Interactions of human leukocyte interferon with vinca alkaloids and other chemotherapeutic agents against human tumors in clonogenic assay

1983 • 147 citations

Combination chemotherapy, glucocorticoids, and interferon alfa in the treatment of multiple myeloma: a Southwest Oncology Group study.

1994 • 139 citations

Treatment of multiple myeloma with recombinant alpha-interferon

1986 • 129 citations

Regulation of the interferon system and cell growth by the IRF transcription factors

1995 • 115 citations

Phase II study of recombinant alpha-2 interferon in resistant multiple myeloma.

1985 • 108 citations

IFN-alpha induces autocrine production of IL-6 in myeloma cell lines.

1991 • 105 citations

Natural interferon-alpha in combination with melphalan/prednisone versus melphalan/prednisone in the treatment of multiple myeloma stages II and III: a randomized study from the Myeloma Group of Central Sweden

1993 • 105 citations

Randomized trial of interferon maintenance in multiple myeloma: a study of the National Cancer Institute of Canada Clinical Trials Group.

1995 • 102 citations

CD34+ progenitor cells from asymptomatic patients are not a major reservoir for human immunodeficiency virus-1

1995 • 98 citations

Interferon alfa‐2b versus no maintenance therapy during the plateau phase in multiple myeloma: a randomized study

1995 • 96 citations

A randomized clinical trial comparing melphalan/prednisone with or without interferon alfa-2b in newly diagnosed patients with multiple myeloma: a Cancer and Leukemia Group B study.

1993 • 94 citations

Interferon-alpha for induction and maintenance in multiple myeloma: Results of two multicenter randomized trials and summary of other studies

1995 • 90 citations

Interferon-α 2b Added to Melphalan-Prednisone for Initial and Maintenance Therapy in Multiple Myeloma

1996 • 83 citations

A comparison of polychemotherapy and melphalan/prednisone for primary remission induction, and interferon-alpha for maintenance treatment, in multiple myeloma. A prospective trial of the German Myeloma Treatment Group

1995 • 75 citations

Human leukocyte interferon and intermittent high-dose melphalan-prednisone administration in the treatment of multiple myeloma: a randomized clinical trial from the Myeloma Group of Central Sweden.

1984 • 68 citations

Disruption by interferon-alpha of an autocrine interleukin-6 growth loop in IL-6-dependent U266 myeloma cells by homologous and heterologous down-regulation of the IL-6 receptor alpha- and beta-chains.

1994 • 59 citations

Differential human multiple myeloma cell line responsiveness to interferon-alpha. Analysis of transcription factor activation and interleukin 6 receptor expression.

1997 • 49 citations

Patient preferences for interferon alfa in multiple myeloma.

1997 • 41 citations

Australian Leukaemia Study Group Myeloma II: a randomized trial of intensive combination chemotherapy with or without interferon in patients with myeloma

1997 • 39 citations

Sensitive inhibitory effect of interferon-alpha on M-protein secretion of human myeloma cells

1989 • 37 citations

Cost-Utility Analysis of Melphalan plus Prednisone With or Without Interferon-α2b in Newly Diagnosed Multiple Myeloma

1997 • 36 citations

A randomized study of VAD therapy with either concurrent or maintenance interferon in patients with newly diagnosed multiple myeloma

1996 • 35 citations

Are the current criteria for response useful in the management of multiple myeloma?

1987 • 31 citations

DEVELOPMENT OF AGGRESSIVE PLASMA CELL LEUKAEMIA UNDER INTERFERON‐ALPHA THERAPY

1991 • 30 citations

Interferons in the treatment of multiple myeloma

1987 • 24 citations

Complete remission induction with combined VBMCP chemotherapy and interferon (rIFN_α2b) in patients with multiple myeloma

1996 • 23 citations

Interleukin-6 activates and regulates transcription factors of the interferon regulatory factor family in M1 cells.

1993 • 23 citations