Mutagenic properties of N‐acetyl‐2‐aminofluorene and its metabolites in relation to the molecular mechanisms of carcinogenesis

Mechanisms of chemical carcinogenesis: nature of proximate carcinogens and interactions with macromolecules.

1966 • 489 citations

N-hydroxy-2-acetylaminofluorene sulfotransferase: its probable role in carcinogenesis and in protein-(methion-S-yl) binding in rat liver.

1970 • 354 citations

The Metabolic Activation of Carcinogenic Aromatic Amines and Amides1

2015 • 349 citations

N-Hydroxy-2-acetylaminofluorene: a metabolite of 2-acetylaminofluorene with increased carcinogenic activity in the rat.

1961 • 336 citations

8-(N-2-Fluorenylacetamido) guanosine, an Arylamidation Reaction Product of Guanosine and the Carcinogen N-Acetoxy-N-2-fluorenylacetamide in Neutral Solution^*

1967 • 335 citations

N-Hydroxylation: A New Metabolic Reaction Observed in the Rat with the Carcinogen 2-Acetylaminofluorene

1960 • 311 citations

Cancer of the Urinary Bladder Induced in Mice with Metabolites of Aromatic Amines and Tryptophan

1957 • 275 citations

The N- and ringhydroxylation of 2-acetylaminofluorene during carcinogenesis in the rat.

1960 • 207 citations

THE COMPARATIVE CARCINOGENICITIES OF 2-ACETYLAMINOFLUORENE AND ITS N-HYDROXY METABOLITE IN MICE, HAMSTERS, AND GUINEA PIGS.

1964 • 202 citations

The Mutagenicity of Chemical Carcinogens: Correlations, Problems, and Interpretations

1971 • 201 citations

Chemistry, Carcinogenicity, and Metabolism of 2-Fluorenamine and Related Compounds

1958 • 189 citations

Chemical Carcinogenesis.

1963 • 180 citations

Enzyme-Catalyzed Reactions of the Carcinogen N -Hydroxy-2-fluorenylacetamide with Nucleic Acid

1968 • 179 citations

Nucleic Acid Guanine: Reaction with the Carcinogen N -Acetoxy-2-Acetylaminofluorene

1966 • 151 citations

On the mechanism of action of carcinogenic aromatic amines

1969 • 138 citations

MOUSE BLADDER CARCINOGENICITY OF CERTAIN TRYPTOPHAN METABOLITES AND OTHER AROMATIC NITROGEN COMPOUNDS SUSPENDED IN CHOLESTEROL.

1964 • 125 citations

Mutations and decreases in density of transforming DNA produced by derivatives of the carcinogens 2-acetyl-aminofluorene and N-methyl-4-aminoazobenzene.

1968 • 118 citations

Sulfotransferase Activation of N-Hydroxy-2-acetylaminofluorene in Rodent Livers Susceptible and Resistant to this Carcinogen

1968 • 114 citations

Determination of the mutagenic activity to bacteriophage T4 of carcinogenic and noncarcinogenic compounds.

1970 • 79 citations

Gene elimination in carcinogenesis: reinterpretation of the somatic mutation theory.

1970 • 66 citations

Coding and Conformational Properties of Oligonucleotides Modified with the Carcinogen N -2-Acetylaminofluorene

1970 • 62 citations

The binding of 2-acetylaminofluorene to rat liver ribonucleic acid in vivo.

1965 • 55 citations

A Further Study of Bladder Implantation in the Mouse as a means of Detecting Carcinogenic Activity: Use of Crushed Paraffin Wax or Stearic Acid as the Vehicle

1963 • 54 citations

Modifications of ribonucleic acid by chemical carcinogens. I. In vitro modification of transfer ribonucleic acid by N-acetoxy-2-acetylaminofluorene

1970 • 51 citations

Mutagenic selectivity for the RNA-forming genes in relation to the carcinogenicity of alkylating agents and polycyclic aromatics.

1972 • 49 citations

Differential mutagenicity of the amine and amide derivatives of nitroso compounds in Drosophila melanogaster

1966 • 47 citations

Biliary excretion of the O-glucuronide of N-hydroxy-2-acetylamino-fluorene by the rat and rabbit.

1967 • 45 citations

THE MUTAGENICITY AND INITIATING ACTIVITY OF SOME AROMATIC AMINE METABOLITES*

1969 • 37 citations

Differential responses of DNA and RNA polymerase to modifications of the template rat liver DNA caused by action of the carcinogen acetylaminofluorene in vivo and in vitro

1968 • 36 citations

Mutability at specific euchromatic and heterochromatic loci with alkylating and nitroso compounds in Drosophila melanogaster

1971 • 31 citations

The conversion of noncarcinogenic aromatic amides to carcinogenic arylhydroxamic acids by synthetic N-hydroxylation.

1967 • 30 citations

Genetic deletions at specific loci by polycyclic hydrocarbons in relation to carcinogenesis

1970 • 24 citations

Induction of bobbed (bb) mutations by polycyclic aromatic carcinogens in Drosophila

1970 • 18 citations

Differences in the binding of 2-Acetylaminofluorene and its N-Hydroxy metabolite to liver nucleic acids of male and female rats.

1971 • 17 citations

Specific Genetic Deletions by a Carcinogenic Hydrocarbon in Drosophila

1969 • 16 citations